Tyrosine partners coordinate DNA nicking by the Salmonella typhimurium plasmid pCU1 relaxase enzyme

FEBS Letters

Volumn 585, Issue 8, 2011, Pages 1216-1222

  Nash, Rebekah P ^a   Niblock, Franklin C ^a   Redinbo, Matthew R ^a,b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Conjugation; DNA nicking; Phosphotyrosine; Plasmid transfer; Relaxase

Indexed keywords

ASPARTIC ACID; BACTERIAL ENZYME; PCU1 RELAXASE; PHENYLALANINE; PLASMID DNA; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MODIFICATION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; SALMONELLA TYPHIMURIUM;

AMINO ACID SEQUENCE; ASPARTIC ACID; BASE SEQUENCE; BIOCATALYSIS; CATALYTIC DOMAIN; DNA BREAKS, SINGLE-STRANDED; DNA NUCLEOTIDYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; SALMONELLA TYPHIMURIUM; SEQUENCE HOMOLOGY, AMINO ACID; TYROSINE;

BACTERIA (MICROORGANISMS); SALMONELLA TYPHIMURIUM;

EID: 79954432560     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.03.043     Document Type: Article

References (26)

1. N. Willetts, and B. Wilkins Processing of plasmid DNA during bacterial conjugation Microbiol. Rev. 48 1984 24 41 (Pubitemid 14150424)
2. D.R. Byrd, and S.W. Matson Nicking by transesterification: the reaction catalysed by a relaxase Mol. Microbiol. 25 1997 1011 1022 (Pubitemid 27410183)
3. F. de la Cruz, L.S. Frost, R.J. Meyer, and E.L. Zechner Conjugative DNA metabolism in Gram-negative bacteria FEMS Microbiol. Rev. 34 2010 18 40
4. E. Lanka, and B.M. Wilkins DNA processing reactions in bacterial conjugation Annu. Rev. Biochem. 64 1995 141 169
5. R. Boer, S. Russi, A. Guasch, M. Lucas, A. Blanco, R. Perez-Luque, M. Coll, and F. de la Cruz Unveiling the molecular mechanism of a conjugative relaxase: the structure of TrwC complexed with a 27-mer DNA comprising the recognition hairpin and the cleavage site J. Mol. Biol. 358 2006 857 869 (Pubitemid 44316628)
6. A. Guasch, M. Lucas, G. Moncalian, M. Cabezas, R. Perez-Luque, F.X. Gomis-Ruth, F. de la Cruz, and M. Coll Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC Nat. Struct. Biol. 10 2003 1002 1010 (Pubitemid 37500492)
7. T.V. Ilyina, and E.V. Koonin Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria Nucleic Acids Res. 20 1992 3279 3285
8. E.V. Koonin, and T.V. Ilyina Computer-assisted dissection of rolling circle DNA replication BioSystems 30 1993 241 268 (Pubitemid 23252641)
9. C. Larkin, R.J. Haft, M.J. Harley, B. Traxler, and J.F. Schildbach Roles of active site residues and the HUH motif of the F plasmid TraI relaxase J. Biol. Chem. 282 2007 33707 33713 (Pubitemid 350159520)
10. S. Datta, C. Larkin, and J.F. Schildbach Structural insights into single-stranded DNA binding and cleavage by F factor TraI Structure 11 2003 1369 1379 (Pubitemid 37412419)
11. C. Larkin, S. Datta, M.J. Harley, B.J. Anderson, A. Ebie, V. Hargreaves, and J.F. Schildbach Inter- and intramolecular determinants of the specificity of single-stranded DNA binding and cleavage by the F factor relaxase Structure 13 2005 1533 1544 (Pubitemid 41427592)
12. S.A. Lujan, L.M. Guogas, H. Ragonese, S.W. Matson, and M.R. Redinbo Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase Proc. Natl. Acad. Sci. USA 104 2007 12282 12287 (Pubitemid 47206129)
13. A.F. Monzingo, A. Ozburn, S. Xia, R.J. Meyer, and J.D. Robertus The structure of the minimal relaxase domain of MobA at 2.1 resolution J. Mol. Biol. 366 2007 165 178 (Pubitemid 46137970)
14. L. Dostal, S. Shao, and J.F. Schildbach Tracking F plasmid TraI relaxase processing reactions provides insight into F plasmid transfer Nucleic Acids Res. 2011 (Advance Access)
15. G. Grandoso, P. Avila, A. Cayon, M.A. Hernando, M. Llosa, and F. de la Cruz Two active-site tyrosyl residues of protein TrwC act sequentially at the origin of transfer during plasmid R388 conjugation J. Mol. Biol. 295 2000 1163 1172
16. E. Scherzinger, V. Kruft, and S. Otto Purification of the large mobilization protein of plasmid RSF1010 and characterization of its site-specific DNA-cleavage/DNA-joining activity FEBS J. 217 1993 929 938 (Pubitemid 23326875)
17. L.M. Street Subdomain organization and catalytic residues of the F factor TraI relaxase domain Biochim. Biophys. Acta 1646 2003 86 99 (Pubitemid 38234694)
18. B. Gonzalez-Perez, M. Lucas, L.A. Cooke, J.S. Vyle, F. de la Cruz, and G. Moncalian Analysis of DNA processing reactions in bacterial conjugation by using suicide oligonucleotides EMBO J. 26 2007 3847 3857 (Pubitemid 47295873)
19. H. Khatoon, R.V. Iyer, and V.N. Iyer A new filamentous bacteriophage with sex-factor specificity Virology 48 1972 145 155
20. M. Konarska-Kozlowska, and V.N. Iyer Physical and genetic organization of the IncN-group plasmid pCU1 Gene 14 1981 195 204 (Pubitemid 11021734)
21. R.P. Nash, S. Habibi, Y. Cheng, S.A. Lujan, and M.R. Redinbo The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1 Nucleic Acids Res. 38 2010 5929 5943
22. E. Paterson, M. More, G. Pillay, C. Cellini, R. Woodgate, G. Walker, V. Iyer, and S. Winans Genetic analysis of the mobilization and leading regions of the IncN plasmids pKM101 and pCU1 J. Bacteriol. 181 1999 2572 2583 (Pubitemid 29181584)
23. S.L. Williams, and J.F. Schildbach Examination of an inverted repeat within the F factor origin of transfer: context dependence of F TraI relaxase DNA specificity Nucleic Acids Res. 34 2006 426 435 (Pubitemid 43240232)
24. F. Dyda, and A.B. Hickman A mob of reps Structure 11 2003 1310 1311 (Pubitemid 37412409)
25. S. Xia, and J. Robertus Effect of divalent ions on the minimal relaxase domain of MobA Arch. Biochem. Biophys. 488 2009 42 47
26. M.P. Garcillan-Barcia, M.V. Francia, and F. de la Cruz The diversity of conjugative relaxases and its application in plasmid classification FEMS Microbiol. Rev. 33 2009 657 687