Time-specific blockade of PDGFR with Imatinib (Glivec®) causes cataract and disruption of lens fiber cells in neonatal mice

Virchows Archiv

Volumn 458, Issue 3, 2011, Pages 349-356

  Zhou, Yin Pin ^a   He, Yang Tao ^a   Chen, Cheng Li ^a   Ji, Jun ^a   Niu, Jian Qin ^a   Wang, Han Zhi ^a   Li, Shi Feng ^a   Huang, Lan ^a   Mei, Feng ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cataract; Congenital; Imatinib; Lens; Migration; Mouse; PDGFR; Postnatal; Proliferation

Indexed keywords

ANTIBODY; IMATINIB; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CATARACT; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOFLUORESCENCE; LENS FIBER; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PUERPERIUM; SIGNAL TRANSDUCTION; ANIMAL; BAGG ALBINO MOUSE; CELL MOTION; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM CELL; LENS; METABOLISM; NICK END LABELING; PATHOLOGY; TIME;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CATARACT; CELL MOVEMENT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; IN SITU NICK-END LABELING; LENS, CRYSTALLINE; MICE; MICE, INBRED BALB C; PIPERAZINES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 79954432145     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-010-1024-3     Document Type: Article

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