Rapid quantification of tilidine, nortilidine, and bisnortilidine in urine by automated online SPE-LC-MS/MS

Analytical and Bioanalytical Chemistry

Volumn 400, Issue 1, 2011, Pages 17-23

  Köhler, Christoph ^a   Grobosch, Thomas ^a   Binscheck, Torsten ^a  

^a Poison Information Centre   (Germany)

Author keywords

Bisnortilidine; LC MS MS; Nortilidine; Online SPE; Tilidine

Indexed keywords

BISNORTILIDINE; LC-MS/MS; NORTILIDINE; ON-LINE SPE; TILIDINE;

FORMIC ACID; LIQUID CHROMATOGRAPHY; METHANOL;

BODY FLUIDS;

DINORTILIDINE; DRUG DERIVATIVE; NORTILIDINE; TILIDINE;

ARTICLE; AUTOMATION; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; METHODOLOGY; REPRODUCIBILITY; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY; URINE;

AUTOMATION; CHROMATOGRAPHY, LIQUID; HUMANS; LIMIT OF DETECTION; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TILIDINE;

EID: 79954431141     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-4466-1     Document Type: Article

References (27)

1. Baselt RC (2008) Disposition of toxic drugs and chemicals in man. Biomedical Publications, Foster City
2. A Trojan HW Beil 1978 Tilidine abuse and dependence Drug Alcohol Depend 3 6 383 391 10.1016/0376-8716(78)90010-8 1:STN:280:DyaE1M%2FmsVOrsw%3D%3D (Pubitemid 9088054)
3. H Berger Börsch-Ising 1979 Potential abuse of tilidine (Valoron) (author's translation) Med Klin 74 15 563 569 1:STN:280:DyaE1M7nvVSntA%3D%3D (Pubitemid 9152828)
4. DR Jasinski KL Preston 1986 Evaluation of tilidine for morphine-like subjective effects and euphoria Drug Alcohol Depend 18 273 292 10.1016/0376-8716(86)90059-1 1:CAS:528:DyaL2sXhsV2gtro%3D (Pubitemid 17219239)
5. J Cordonnier M van den Heede Heyndrickx 1987 Disposition of tilidine in a fatal poisoning in man J Anal Toxicol 11 105 109 1:STN:280:DyaL2s3lsFyktg%3D%3D (Pubitemid 17077487)
6. R Regenthal M Krüger M Richter R Preiss 1998 Poisoning with tilidine and naloxone: toxicokinetic and clinical observations Hum Exp Toxicol 17 593 597 10.1191/096032798678908071 1:STN:280:DyaK1M%2FotFSisA%3D%3D (Pubitemid 28542572)
7. U Brennscheidt KU Seiler D Thomann 2000 Pharmacokinetics of nortilidine and naloxone after administration of tilidine/naloxone solution or tilidine/naloxone sustained release tablets Drug Res 50 1015 1022 1:CAS:528:DC%2BD3cXoslyls7g%3D
8. J Weiss E Sawa KD Riedel WE Haefeli G Mikus 2008 In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6 Naunyn Schmiedebergs Arch Pharmacol 378 3 275 282 10.1007/s00210-008-0294-7 1:CAS:528:DC%2BD1cXpvVKgurY%3D
9. C Thierry JM Boeynaems M Paolo 2005 Actions of tilidine and nortilidine on cloned opioid redeptors Eur J Pharm 506 205 208 10.1016/j.ejphar.2004.11.020 1:CAS:528:DC%2BD2cXhtFGgs77M (Pubitemid 41071391)
10. KO Vollmer H Achenbach 1974 Zum Metabolismus von dl-trans-2- dimethylamino-1-phenylcyclohex-3-en-trans-1-carbonsäureäthylester- hydrochlorid Drug Res 24 9 1237 1242 1:CAS:528:DyaE2MXltFeitQ%3D%3D
11. KO Vollmer A Poisson 1976 Zum metabolismus von dl-trans-2-dimethylamino- 1-phenylcyclohex-3-en-trans-1-carbonsäureäthylester-hydrochlorid (Tilidin-HCl) Drug Res 26 10 1827 1836 1:CAS:528:DyaE2sXht1c%3D
12. KO Vollmer A Hodenberg 1977 Zum metabolismus von dl-trans-2- dimethylamino-1-phenylcyclohex-3-en-trans-1-carbonsäureäthylester- hydrochlorid (Tilidin-HCl) Drug Res 27 2 1706 1713 1:CAS:528:DyaE2sXlvFemtL0%3D
13. Narcotics Act (2009) Federal Department of Justice, Berlin. http://bundesrecht.juris.de/bundesrecht/btmg-1981/gesamt.pdf, accessed 23 Aug 2010
14. H Hengy KO Vollmer V Gladlau 1987 Gas-chromatographic determination of nanogram amounts of enantiomers of nortilidine, a main metabolite of tilidine, in biological specimen Clin Chem 24 4 692 697
15. F Musshoff J Trafkowski U Kuepper BJ Madea 2006 An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites Mass Spectrom 41 5 633 640 10.1002/jms.1021 1:CAS:528:DC%2BD28XntVCms70%3D (Pubitemid 44023118)
16. H Hengy KO Vollmer V Gladigau 1987 GLC determination of tilidine, nortilidine and bisnortilidine in biological fluids with a nitrogen-sensitive detector J Pharm Sci 67 1765 1768 10.1002/jps.2600671237
17. J Cordonnier A Wauters A Heyndrickx 1987 Comparison of a GLC-NPD method with a GLC-MS-SIM procedure for the determination of tilidine and its metabolites in plasma J Anal Toxicol 11 4 144 148 1:CAS:528:DyaL2sXltVyksLw%3D (Pubitemid 17102319)
18. JL Veuthey S Souverain S Rudaz 2004 Column-switching procedures for the fast analysis of drugs in biologic samples Ther Drug Monit 26 2 161 166 10.1097/00007691-200404000-00013 1:CAS:528:DC%2BD2cXjvFOkurw%3D (Pubitemid 38501211)
19. C Köhler T Grobosch T Binscheck 2009 Rapid quantification of tilidine, nortilidine and naloxone in urine by LC-ESI-MS/MS Bull TIAFT 2009 O18
20. T Hyötyläinen 2007 Principles, developments and applications of on-line coupling of extraction with chromatography J Chromatogr A 1153 14 28 10.1016/j.chroma.2006.11.102 (Pubitemid 46755185)
21. AF Grieshaber KA Moore B Levine 2001 The detection of psilocin in human urine J Forensic Sci 46 627 630 1:CAS:528:DC%2BD3MXktFKisLk%3D (Pubitemid 32520587)
22. FT Peters M Hartung M Herbold G Schmitt T Daldrup F Muhoff 2009 Richtlinie der GTFCh zur Qualitätssicherung bei forensisch-toxikologischen Untersuchungen: Anforderungen an die Validierung von Analysenmethoden Toxichem Krimtech 76 3 185 208
23. U.S. Department of Health and Human Services. Food and Drug Administration (2001) Guidance for industry. Bioanalytical method validation. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/ Guidances/UCM070107.pdf
24. M Del Mar Ramírez Fernández SMR Wille N Samyn M Wood M López-Rivadulla G De Boeck 2009 High-throughout analysis of amphetamines in blood and urine with online solid-phase extraction-liquid chromatography-tandem mass spectrometry J Anal Toxicol 33 578 587
25. L Schönberg T Grobosch D Lampe C Kloft 2006 New screening method for basic compounds in urine by on-line extraction-high-performance liquid chromatography with photodiode-array detection J Chromatogr A 1134 177 185 10.1016/j.chroma.2006.09.009 (Pubitemid 44633944)
26. U Brennscheidt U Brunnmüller D Proppe P Thomann KU Seiler 2007 Pharmacokinetics of tilidine and naloxone in patients with severe hepatic impairment Drug Res 57 2 106 111 1:CAS:528:DC%2BD2sXkt1Kqsr4%3D (Pubitemid 46383951)
27. KO Vollmer P Thomann H Hengy 1989 Pharmacokinetics of tilidine and metabolites in man Drug Res 39 10 1283 1288 1:CAS:528:DyaK3cXhsVY%3D (Pubitemid 19255307)