Structural studies of NEMO and TRAF6: Implications in NF-κB activation

Advances in Experimental Medicine and Biology

Volumn 691, Issue , 2011, Pages 89-91

  Wu, Hao ^a   Lo, Yu Chih ^a   Yin, Qian ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; I KAPPA B KINASE; UBIQUITIN;

ADAPTIVE IMMUNITY; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CONFERENCE PAPER; DEVELOPMENT; DIMERIZATION; ENZYME PHOSPHORYLATION; GENETIC CONSERVATION; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; ARTICLE; CHEMISTRY; METABOLISM; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN ANALYSIS; UBIQUITINATION;

I-KAPPA B KINASE; MAGNETIC RESONANCE SPECTROSCOPY; MUTAGENESIS; NF-KAPPA B; PROTEIN INTERACTION MAPPING; TNF RECEPTOR-ASSOCIATED FACTOR 6; UBIQUITINATION; UBIQUITINS;

EID: 79954429442     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-6612-4_9     Document Type: Conference Paper

References (7)

1. Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ (2006) Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22: 245-257
2. Gilmore TD (2006) Introduction to NF-kappaB: Players, pathways, perspectives. Oncogene 25:6680-6684
3. Lo YC, Lin SC, Rospigliosi CC, Conze DB, Wu C, Ashwell JD, Eliezer D, Wu H (2009) Structural basis for recognition of diubiquitins by NEMO. Mol Cell 33:602-615
4. Scheidereit C (2006) IkappaB kinase complexes: Gateways to NF-kappaB activation and transcription. Oncogene 25:6685-6705
5. Tokunaga F, Sakata SI, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S et al (2009) Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol 11:123-132
6. Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD (2006) Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol 8:398-406
7. Yin Q, Lin SC, Lamothe B, Lu M, Lo YC, Hura G, Zheng L, Rich R, CamposAD, Myszka DG et al (2009) E2 interaction and dimerization in the crystal structure of TRAF6. Nat Struct Mol Biol 16:658-666