Synthesis, characterization and biological evaluation of [188Re(N)(cys~)(PNP)]+/0 mixed-ligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals

Nuclear Medicine and Biology

Volumn 38, Issue 3, 2011, Pages 399-415

  Thieme, Stefan ^a   Agostini, Stefania ^b   Bergmann, Ralf ^a   Pietzsch, Jens ^a   Pietzsch, Hans Jürgen ^a   Carta, Davide ^b   Salvarese, Nicola ^b   Refosco, Fiorenzo ^c   Bolzati, Cristina ^b,c  

^a INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^b UNIVERSITY OF PADOVA   (Italy)

^c CNR   (Italy)

Author keywords

188Re nitrido; Diphosphinoamines; Peptide; Rhenium; Technetium; Therapy

Indexed keywords

EDETIC ACID; GLUTATHIONE; RADIOPHARMACEUTICAL AGENT; RHENIUM COMPLEX; RHENIUM NITRIDO ACETYLCYSTEINE N,N BIS[(DIMETHOXYPROPYL)PHOSPHINOETHYL]METHOXYETHYLAMINE; RHENIUM NITRIDO ACETYLCYSTEINE N,N BIS[(DIMETHOXYPROPYL)PHOSPHINOETHYL]METHOXYETHYLAMINE RE 188; RHENIUM NITRIDO CYSTEINE DIPHOSPHINOAMINE RE 188; RHENIUM NITRIDO CYSTEINE ETHYL ESTER N,N BIS[(DIMETHOXYPROPYL)PHOSPHINOETHYL]METHOXYETHYLAMINE; RHENIUM NITRIDO CYSTEINE METHYL ESTER N,N BIS[(DIMETHOXYPROPYL)PHOSPHINOETHYL]METHOXYETHYLAMINE; RHENIUM NITRIDO CYSTEINE N,N BIS[(DIMETHOXYPROPYL)PHOSPHINOETHYL]ETHOXYETHYLAMINE RE 188; RHENIUM NITRIDO CYSTEINE N,N BIS[(DIMETHOXYPROPYL)PHOSPHINOETHYL]METHOXYETHYLAMINE RE 188; RHENIUM NITRIDO DITHIOCARBAZATE N,N BIS[(DIMETHOXYPROPYL)PHOSPHINOETHYL]ETHOXYETHYLAMINE RE 188; RHENIUM NITRIDO DITHIOCARBAZATE N,N BIS[(DIMETHOXYPROPYL)PHOSPHINOETHYL]METHOXYETHYLAMINE; RHENIUM NITRIDO DITHIOCARBAZATE N,N BIS[(DIMETHOXYPROPYL)PHOSPHINOETHYL]METHOXYETHYLAMINE RE 188; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME DEGRADATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGE ANALYSIS; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PH; QUANTITATIVE ANALYSIS; RADIOCHEMISTRY; RAT; REACTION OPTIMIZATION; REACTION TIME; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; CYSTEINE; LIGANDS; MALE; PHOSPHINES; RADIOISOTOPES; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; RHENIUM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 79954421768     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2010.09.006     Document Type: Article

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