Let-7 MicroRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: Analysis of 56 lipomas and liposarcomas with molecular cytogenetic data

Genes Chromosomes and Cancer

Volumn 50, Issue 6, 2011, Pages 442-455

  Bianchini, Laurence ^a,b   Saâda, Esma ^a,b   Gjernes, Elisabet ^a,b   Marty, Marion ^c   Haudebourg, Juliette ^a   Birtwisle Peyrottes, Isabelle ^d   Keslair, Frédérique ^a,b   Chignon Sicard, Bérangère ^a   Chamorey, Emmanuel ^d   Pedeutour, Florence ^a,b  

^a UNIVERSITY HOSPITAL OF NICE   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c INSTITUT BERGONIÉ   (France)

^d CENTRE ANTOINE LACASSAGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP A2 PROTEIN; LET 7 MICRORNA; MICRORNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOGENETICS; GENE AMPLIFICATION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPOMA; LIPOSARCOMA; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOCYTES; ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HMGA2 PROTEIN; HUMANS; INFANT; LIPOMA; LIPOSARCOMA; MALE; MICRORNAS; MIDDLE AGED;

EID: 79954421446     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20869     Document Type: Article

References (49)

1. Ashar HR, Fejzo MS, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K. 1995. Disruption of the architectural factor HMGI-C: DNA-binding at hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82: 57-65.
2. Barh D, Malhotra R, Ravi B, Sindhurani P. 2010. MicroRNA let-7: An emerging next-generation cancer therapeutic. Curr Oncol 17: 70-80.
3. Bartuma H, Hallor KH, Panagopoulos I, Collin A, Rydholm A, Gustafson P, Bauer HC, Brosjo O, Domanski HA, Mandahl N, Mertens F. 2007. Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype. Genes Chromosomes Cancer 46: 594-606.
4. Bartuma H, Panagopoulos I, Collin A, Trombetta D, Domanski HA, Mandahl N, Mertens F. 2009. Expression levels of HMGA2 in adipocytic tumors correlate with morphologic and cytogenetic subgroups. Mol Cancer 8: 36.
5. Battista S, Fidanza V, Fedele M, Klein-Szanto AJ, Outwater E, Brunner H, Santoro M, Croce CM, Fusco A. 1999. The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res 59: 4793-4797.
6. Berner JM, Meza-Zepeda LA, Kools PF, Forus A, Schoenmakers EF, Van De Ven WJ, Fodstad O, Myklebost O. 1997. HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas. Oncogene 14: 2935-2941.
7. Billing V, Mertens F, Domanski HA, Rydholm A. 2008. Deep-seated ordinary and atypical lipomas: Histopathology, cytogenetics, clinical features, and outcome in 215 tumours of the extremity and trunk wall. J Bone Joint Surg Br 90: 929-933.
8. Borrmann L, Wilkening S, Bullerdiek J. 2001. The expression of HMGA genes is regulated by their 3'UTR. Oncogene 20: 4537-4541.
9. Boyerinas B, Park SM, Hau A, Murmann AE, Peter ME. 2010. The role of let-7 in cell differentiation and cancer. Endocr Relat Cancer 17: F19-F36.
10. Chiappetta G, Ferraro A, Vuttariello E, Monaco M, Galdiero F, De Simone V, Califano D, Pallante P, Botti G, Pezzullo L, Pierantoni GM, Santoro M, Fusco A. 2008. HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias. Eur J Cancer 44: 1015-1021.
11. Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB. 2008. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res 68: 8535-8540.
12. Cleynen I, Van De Ven WJ. 2008. The HMGA proteins: A myriad of functions. Int J Oncol 32: 289-305.
13. Coindre JM, Hostein I, Maire G, Derre J, Guillou L, Leroux A, Ghnassia JP, Collin F, Pedeutour F, Aurias A. 2004. Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: Histological review, genomic profile, and MDM2 and CDK4 status favour a single entity. J Pathol 203: 822-830.
14. Craver RD, Fonseca P, Carr R. 2010. Pediatric epithelial salivary gland tumors: Spectrum of histologies and cytogenetics at a children's hospital. Pediatr Dev Pathol 13: 348-353.
15. Dal Cin P, Thomas A, Weremowicz S. 2004. An intragenic rearrangement of HMGA2 is not necessary for lipoma formation. Cancer Genet Cytogenet 149: 178-179.
16. Dahlen A, Debiec-Rychter M, Pedeutour F, Domanski HA, Hoglund M, Bauer HC, Rydholm A, Sciot R, Mandahl N, Mertens F. 2003. Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. Int J Cancer 103: 616-623.
17. Dei Tos AP, Doglioni C, Piccinin S, Sciot R, Furlanetto A, Boiocchi M, Dal Cin P, Maestro R, Fletcher CD, Tallini G. 2000. Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours. J Pathol 190: 531-536.
18. Dreux N, Marty M, Chibon F, Velasco V, Hostein I, Ranchere-Vince D, Terrier P, Coindre JM. 2010. Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: About a series of 1052 cases. Mod Pathol 23: 1657-1666.
19. Eulalio A, Behm-Ansmant I, Izaurralde E. 2007. P-bodies: At the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol 8: 9-22.
20. Fedele M, Berlingieri MT, Scala S, Chiariotti L, Viglietto G, Rippel V, Bullerdiek J, Santoro M, Fusco A. 1998. Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts. Oncogene 17: 413-418.
21. Fletcher CDM, Unni KK, Mertens F, editors. 2002. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press.
22. Gabrielsson BG, Olofsson LE, Sjogren A, Jernas M, Elander A, Lonn M, Rudemo M, Carlsson LM. 2005. Evaluation of reference genes for studies of gene expression in human adipose tissue. Obes Res 13: 649-652.
23. Italiano A, Bianchini L, Keslair F, Bonnafous S, Cardot-Leccia N, Coindre JM, Dumollard JM, Hofman P, Leroux A, Mainguene C, Peyrottes I, Ranchere-Vince D, Terrier P, Tran A, Gual P, Pedeutour F. 2008a. HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon. Int J Cancer 122: 2233-2241.
24. Italiano A, Chambonniere ML, Attias R, Chibon F, Coindre JM, Pedeutour F. 2008b. Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas. Cancer Genet Cytogenet 184: 99-104.
25. Italiano A, Bianchini L, Gjernes E, Keslair F, Ranchere-Vince D, Dumollard JM, Haudebourg J, Leroux A, Mainguene C, Terrier P, Chibon F, Coindre JM, Pedeutour F. 2009. Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas. Clin Cancer Res 15: 5696-5703.
26. Lee YS, Dutta A. 2007. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev 21: 1025-1030.
27. Lettre G, Jackson AU, Gieger C, Schumacher FR, Berndt SI, Sanna S, Eyheramendy S, Voight BF, Butler JL, Guiducci C, Illig T, Hackett R, Heid IM, Jacobs KB, Lyssenko V, Uda M, Boehnke M, Chanock SJ, Groop LC, Hu FB, Isomaa B, Kraft P, Peltonen L, Salomaa V, Schlessinger D, Hunter DJ, Hayes RB, Abecasis GR, Wichmann HE, Mohlke KL, Hirschhorn JN. 2008. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet 40: 584-591.
28. Mahajan A, Liu Z, Gellert L, Zou X, Yang G, Lee P, Yang X, Wei JJ. 2010. HMGA2: A biomarker significantly overexpressed in high-grade ovarian serous carcinoma. Mod Pathol 23: 673-681.
29. Mandahl N, Hoglund M, Mertens F, Rydholm A, Willen H, Brosjo O, Mitelman F. 1994. Cytogenetic aberrations in 188 benign and borderline adipose tissue tumors. Genes Chromosomes Cancer 9: 207-215.
30. Mayr C, Bartel DP. 2009. Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell 138: 673-684.
31. Mayr C, Hemann MT, Bartel DP. 2007. Disrupting the pairing between let-7 and HMGA2 enhances oncogenic transformation. Science 315: 1576-1579.
32. Merscher S, Marondel I, Pedeutour F, Gaudray P, Kucherlapati R, Turc-Carel C. 1997. Identification of new translocation breakpoints at 12q13 in lipomas. Genomics 46: 70-77.
33. Meza-Zepeda LA, Berner JM, Henriksen J, South AP, Pedeutour F, Dahlberg AB, Godager L, Nizetic D, Forus A, Myklebost O. 2001. Ectopic sequences from truncated HMGIC in liposarcomas are derived from various amplified chromosomal regions. Genes Chromosomes Cancer 31: 264-273.
34. Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR. 2004. Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol 5: R68.
35. Mu G, Liu H, Zhou F, Xu X, Jiang H, Wang Y, Qu Y. 2010. Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation, invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. Hum Pathol 41: 493-502.
36. Odero MD, Grand FH, Iqbal S, Ross F, Roman JP, Vizmanos JL, Andrieux J, Lai JL, Calasanz MJ, Cross NC. 2005. Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies. Leukemia 19: 245-252.
37. Peng Y, Laser J, Shi G, Mittal K, Melamed J, Lee P, Wei JJ. 2008. Antiproliferative effects by let-7 repression of high-mobility group A2 in uterine leiomyoma. Mol Cancer Res 6: 663-673.
38. Persson F, Andren Y, Winnes M, Wedell B, Nordkvist A, Gudnadottir G, Dahlenfors R, Sjogren H, Mark J, Stenman G. 2009. High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2. Genes Chromosomes Cancer 48: 69-82.
39. Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van De Ven WJ. 1996. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 36: 118-129.
40. Pierantoni GM, Finelli P, Valtorta E, Giardino D, Rodeschini O, Esposito F, Losa M, Fusco A, Larizza L. 2005. High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy. Endocr Relat Cancer 12: 867-874.
41. Quade BJ, Weremowicz S, Neskey DM, Vanni R, Ladd C, Dal Cin P, Morton CC. 2003. Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15. Cancer Res 63: 1351-1358.
42. Schoenmakers EF, Wanschura S, Mols R, Bullerdiek J, Van Den Berghe H, Van De Ven WJ. 1995. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet 10: 436-444.
43. Shi G, Perle MA, Mittal K, Chen H, Zou X, Narita M, Hernando E, Lee P, Wei JJ. 2009. Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma. J Cell Mol Med 13: 3898-3905.
44. Sirvent N, Forus A, Lescaut W, Burel F, Benzaken S, Chazal M, Bourgeon A, Vermeesch JR, Myklebost O, Turc-Carel C, Ayraud N, Coindre JM, Pedeutour F. 2000. Characterization of centromere alterations in liposarcomas. Genes Chromosomes Cancer 29: 117-129.
45. Sun T, Fu M, Bookout AL, Kliewer SA, Mangelsdorf DJ. 2009. MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol 23: 925-931.
46. Tallini G, Dal Cin P, Rhoden KJ, Chiapetta G, Manfioletti G, Giancotti V, Fusco A, Van Den Berghe H, Sciot R. 1997. Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: Immunohistochemical reactivity correlates with karyotypic alterations. Am J Pathol 151: 37-43.
47. Tallini G, Vanni R, Manfioletti G, Kazmierczak B, Faa G, Pauwels P, Bullerdiek J, Giancotti V, Van Den Berghe H, Dal Cin P. 2000. HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes. Lab Invest 80: 359-369.
48. Wang X, Hulshizer RL, Erickson-Johnson MR, Flynn HC, Jenkins RB, Lloyd RV, Oliveira AM. 2009. Identification of novel HMGA2 fusion sequences in lipoma: Evidence that deletion of let-7 miRNA consensus binding site 1 in the HMGA2 3' UTR is not critical for HMGA2 transcriptional upregulation. Genes Chromosomes Cancer 48: 673-678.
49. Zhou X, Benson KF, Ashar HR, Chada K. 1995. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 376: 771-774.