Translational/personalized medicine, pharmaco/surgico/radiogenomics, lymphatic spread of cancer, and medical ignoromes

Journal of Surgical Oncology

Volumn 103, Issue 6, 2011, Pages 501-507

  Witte, Marlys H ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

ignoramics; lymphology; personalized medicine; pharmacogenomics; surgicogenomics; translation

Indexed keywords

APC PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA; DNA GLYCOSYLASE MUTY; MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; PROTEIN RET; RNA; SMAD4 PROTEIN;

ARTICLE; BIOINFORMATICS; BREAST CANCER; COLORECTAL CANCER; GARDNER SYNDROME; GASTROINTESTINAL POLYPOSIS; GENE; GENOME; GENOMICS; GENOTYPE; HUMAN; LYMPH; LYMPH NODE; LYMPH VESSEL; LYMPHOCYTE; MEDICAL IGNORAMICS; MEN 1 GENE; MLH3 GENE; MOUSE; MULTIPLE ENDOCRINE NEOPLASIA; NONHUMAN; OVARY CANCER; PANCREAS ISLET CELL CARCINOMA; PERSONALIZED MEDICINE; PHARMACOGENOMICS; PHENOTYPE; PMS1 GENE; PRIORITY JOURNAL; RADIOGENOMICS; SURGICOGENOMICS; THYROID CARCINOMA; TRANSLATION INITIATION;

GENOMICS; HUMANS; INDIVIDUALIZED MEDICINE; LYMPHATIC METASTASIS; MOLECULAR TARGETED THERAPY; NEOPLASMS; PHARMACOGENETICS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 79953892271     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21738     Document Type: Article

References (27)

1. Sarkar S,: Molecular models of life: Philosophical papers on molecular biology. Cambridge, MA, London, England: The MIT Press; 2005.
2. Witte M, Crown P, Bernas M, et al.: " Ignoramics" in medical and pre-medical education. J Inv Med 2008; 56: 897-901.
3. Watson J, Crick F,: A structure for deoxyribose nucleic acid. Nature 1953; 171: 737.
4. Watson JD,: The double helix: A personal account of the discovery of the structure of DNA. New York: Atheneum; 1968.
5. McCarty M,: The transforming principle: Discovering that genes are made of DNA. New York: WW Norton & Company; 1985.
6. Avery OT, MacLeod CM, McCarty M,: Studies on the chemical nature of the substance inducing transformation of pneumococcal types: Induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. J Exp Med 1944; 79: 137-158.
7. Witte MH,: Joshua Lederberg's interest in ignorance. Science 2008; 320: 1159. (Pubitemid 351929488)
8. Kornberg A,: Severo Ochoa (1905-1993). Nature 1993; 366: 408.
9. You YN, Lakhani VT, Wells SA,: The role of prophylactic surgery in cancer prevention. World J Surgery 2007; 31: 450-464. (Pubitemid 46356093)
10. Witte MH,: Translational lymphology and the Földiklinik. Eur J Lymphol (in press).
11. Witte MH,: Standing on the shoulders of giants: The past, present, and future of the International Society of Lymphology. (Opening lecture.) In: Proceedings of the 22nd International Congress of Lymphology, Sydney, Australia, 9/25/09. Lymphology 43(Suppl) (in press and CD-ROM).
12. Starling EH,: Physiologic factors involved in the causation of dropsy. Lancet 1896; 1: 1267-1270.
13. Sabin FR,: On the origin and development of the lymphatic system from the veins and the development of the lymph hearts and the thoracic duct in the pig. Am J Anat 1902; 1: 367.
14. Kinmonth JB,: The lymphatic diseases, lymphography, and surgery. Baltimore: Williams and Wilkins; 1972.
15. Földi M, Földi E,: Textbook of Lymphology, 3rd edition, Chapter 16. München, Germany: Urban & Fischer Verlag; (in press).
16. Witte MH, Witte CL,: What we don't know about cancer. Epilogue. In: Otter W, Root-Bernstein R, Koten J-W (editors). What is Cancer? Theories on Carcinogenesis. Anticancer Res 1999; 19:4919-4934.
17. Witte MH, Jones K, Wilting J, et al.: Structure-function relationships in the lymphatic system and implications for cancer biology. Cancer Metastasis Rev 2006; 25: 159-184. (Pubitemid 43886395)
18. Gale NW, Thurston G, Hackett SF, et al.: Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1. Dev Cell 2002; 3: 411-423.
19. Fang JM, Dagenais SL, Erickson RP, et al.: Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome. Am J Hum Genet 2000; 67: 1382-1388.
20. Kriederman BM, Myloyde TL, Witte MH, et al.: Foxc2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome. Hum Mol Genet 2003; 12: 1179-1185. (Pubitemid 36622150)
21. Petrova T, Karpanen T, Norrmen C, et al.: Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema-distichiasis. Nature Med 2004; 10: 974-981. (Pubitemid 39273739)
22. Witte M, Dellinger M, McDonald DM, et al.: Lymphangiogenesis/ Hemangiogenesis: Potential targets for therapy. Special issue of Seminars in Surgical Oncology: The Pivotal Role of the Lymphovascular System in Cancer Metastasis. Leong, S, guest editor. J Surg Oncol (in press).
23. Witte MH, Dellinger M, Bernas MJ, et al.: Molecular lymphology and genetics of lymphedema-angiodysplasia syndromes. In:, Földi M, Földi E, editors. Textbook of Lymphology, 3rd edition, Chapter 16. München, Germany: Urban & Fischer Verlag; (in press).
24. Witte MH, Crown P, Bernas M, et al.: Lessons learned from ignorance: The curriculum on medical (and other) ignorance. In:, Vitek W, Jackson W, editors. The virtues of ignorance: Complexity, sustainability, and the limits of knowledge. Lexington, KY: The University Press of Kentucky; 2008. pp. 251-272.
25. Witte MH, Crown PC, Hall JR, et al.: Virtual CRC-CTSA and Medical Ignorance Exploratorium (MIEx): Translating translation. ACRT/SCTS Joint Annual Meeting, Washington DC 4/5-7/2010, Clin Translat Sci 2010; 3: S54, #A286.
26. Gunawardena J,: Biological systems theory. Science 2010; 328: 581-582.
27. Gross DJ,: The discovery of asymptotic freedom and the emergence of QCD. Nobel Lecture, December 8, 2004, Kavli Institute for Theoretical Physics, UCSB, Santa Barbara, CA. USA.