Infection reduction strategies including antibiotic stewardship protocols in surgical and trauma intensive care units are associated with reduced resistant gram-negative healthcare-associated infections

Surgical Infections

Volumn 12, Issue 1, 2011, Pages 15-25

  Dortch, Marcus J ^a   Fleming, Sloan B ^a   Kauffmann, Rondi M ^a   Dossett, Lesly A ^a   Talbot, Thomas R ^a   May, Addison K ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE DERIVATIVE; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; CEFEPIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; CILASTATIN PLUS IMIPENEM; ERTAPENEM; LEVOFLOXACIN; METRONIDAZOLE; PIPERACILLIN PLUS TAZOBACTAM; QUINOLONE DERIVATIVE; TOBRAMYCIN;

ACINETOBACTER INFECTION; ADULT; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL VIRULENCE; CLINICAL PROTOCOL; EMERGENCY HEALTH SERVICE; ENTEROBACTERIACEAE INFECTION; FEMALE; GRAM NEGATIVE INFECTION; HEALTH CARE POLICY; HEALTH PROGRAM; HOSPITAL INFECTION; HUMAN; INFECTION CONTROL; INFECTION RESISTANCE; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; MULTIDRUG RESISTANCE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PSEUDOMONAS INFECTION; SURGICAL WARD; TREATMENT PLANNING;

ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRUG UTILIZATION; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; HOSPITALS, UNIVERSITY; HUMANS; INCIDENCE; INFECTION CONTROL; INTENSIVE CARE UNITS; MALE; MIDDLE AGED;

EID: 79953874331     PISSN: 10962964     EISSN: None     Source Type: Journal    
DOI: 10.1089/sur.2009.059     Document Type: Article

References (47)

1. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171:388-416.
2. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36: 296-327.
3. Hidron AI, Edwards JR, Patel J, et al. NHSN annual update: Antimicrobial-resistant pathogens associated with healthcare-associated infections: Annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008;29:996-1011.
4. Cosgrove SE, Kaye KS, Eliopoulous GM, Carmeli Y. Health and economic outcomes of the emergence of third-generation cephalosporin resistance in Enterobacter species. Arch Intern Med 2002;162:185-190. (Pubitemid 34098188)
5. Evans HL, Lefrak SN, Lyman J, et al. Cost of gram-negative resistance. Crit Care Med 2007;35:89-95. (Pubitemid 46035682)
6. Garcia-Garmendia JL, Ortiz-Leyba C, Garnacho-Montero J, et al. Mortality and the increase in length of stay attributable to the acquisition of Acinetobacter in critically ill patients. Crit Care Med 1999;27:1794-1799. (Pubitemid 29455106)
7. Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: A risk factor for hospital mortality among critically ill patients. Chest 1999;115:462-474. (Pubitemid 29083057)
8. Lautenbach E, Metlay JP, Bilker WB, et al. Association between fluoroquinolone resistance and mortality in Escher-ichia coli and Klebsiella pneumoniae infections: The role of inadequate empirical antimicrobial therapy. Clin Infect Dis 2005;41:923-929. (Pubitemid 41368212)
9. Peralta G, Sanchez MB, Garrido JC, et al. Impact of antibiotic resistance and of adequate empirical antibiotic treatment in the prognosis of patients with Escherichia coli bacteraemia. J Antimicrob Chemother 2007;60:855-863. (Pubitemid 47434266)
10. Schwaber MJ, Carmeli Y. Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: A systematic review and meta-analysis. J Antimicrob Chemother 2007;60: 913-920. (Pubitemid 47617735)
11. Schwaber MJ, Navon-Venezia S, Kaye KS, et al. Clinical and economic impact of bacteremia with extended-spectrum-beta-lactamase-producing Enterobacteriaceae. Antimicrob Agents Chemother 2006;50:1257-1262.
12. Trouillet JL, Chastre J, Vuagnat A, et al. Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med 1998;157:531-539. (Pubitemid 28090546)
13. Tumbarello M, Sanguinetti M, Montuori E, et al. Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta- lactamase-producing Enterobacteriaceae: Importance of inadequate initial antimicrobial treatment. Antimicrob Agents Chemother 2007;51: 1987-1994. (Pubitemid 46903084)
14. Velmahos GC, Toutouzas KG, Sarkisyan G, et al. Severe trauma is not an excuse for prolonged antibiotic prophylaxis. Arch Surg 2002;137:537-541
15. CDC Definitions of Nosocomial Infections. Available at www.cdc.gov/ncidod/dhqp/pdf/nnis/NosInfDefinitions.pdf
16. National Nosocomial Infections Surveillance System (NNIS). Available at www.cdc.gov/ncidod/dhqp/nnis.html. Accessed November 11, 2008.
17. May AK, Fleming SB, Carpenter RO, et al. Influence of broad-spectrum antibiotic prophylaxis on intracranial pressure monitor infections and subsequent infectious complications in head-injured patients. Surg Infect 2006;7:409-417. (Pubitemid 44857094)
18. Fabian TC, Croce MA, Payne LW, et al. Duration of antibiotic therapy for penetrating abdominal trauma: A prospective trial. Surgery 1992;112:788-794.
19. Bratzler DW, Houck PM. Antimicrobial prophylaxis for surgery: An advisory statement from the National Surgical Infection Prevention Project. Clin Infect Dis 2004;38:1706-1715. (Pubitemid 38781662)
20. Bonten MJ, Bergmans DC, Stobberingh EE, et al. Implementation of bronchoscopic techniques in the diagnosis of ventilator-associated pneumonia to reduce antibiotic use. Am J Respir Crit Care Med 1997;156:1820-1824. (Pubitemid 28011788)
21. Heyland DK, Cook DJ, Marshall J, et al. The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia. Canadian Critical Care Trials Group. Chest 1999;115:1076-1084. (Pubitemid 29193680)
22. Luna CM, Vujacich P, Niederman MS, et al. Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 1997;111:676-685. (Pubitemid 27132946)
23. Chastre J, Wolff M, Fagon JY, et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: A randomized trial. JAMA 2003;290:2588-2598. (Pubitemid 37443289)
24. Rello J, Vidaur L, Sandiumenge A, et al. De-escalation therapy in ventilator-associated pneumonia. Crit Care Med 2004;32:2183-2190. (Pubitemid 39491796)
25. Raymond DP, Pelletier SJ, Crabtree TD, et al. Impact of a rotating empiric antibiotic schedule on infectious mortality in an intensive care unit. Crit Care Med 2001;29:1101-1108. (Pubitemid 32554319)
26. Performance standards for antimicrobial susceptibility testing; 17th informational supplement. Clinical Laboratory Standards Institute document M100-S187 [ISBN 1-56238-625-5] 2007;27:1-182.
27. Gaynes R, Edwards JR. Overview of nosocomial infections caused by gram-negative bacilli. Clin Infect Dis 2005;41:848-854. (Pubitemid 41266753)
28. Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii: Emergence of a successful pathogen. Clin Microbiol Rev 2008;21:538-582.
29. Ariffin H, Navaratnam P, Mohamed M, et al. Ceftazidime-resistant Klebsiella pneumoniae bloodstream infection in children with febrile neutropenia. Int J Infect Dis 2000;4:21-25. (Pubitemid 30136621)
30. Giske CG, Monnet DL, Cars O, Carmeli Y. Clinical and economic impact of common multidrug-resistant gram-negative bacilli. Antimicrob Agents Chemother 2008;52:813-821. (Pubitemid 351358357)
31. Harbarth S, Samore MH, Lichtenberg D, Carmeli Y. Prolonged antibiotic prophylaxis after cardiovascular surgery and its effect on surgical site infections and antimicrobial resistance. Circulation 2000;101:2916-2921. (Pubitemid 30415881)
32. Puzniak L, Teutsch S, Powderly W, Polish L. Has the epidemiology of nosocomial candidemia changed? Infect Control Hosp Epidemiol 2004;25:628-633. (Pubitemid 39095043)
33. Namias N, Harvill S, Ball S, McKenney MG, et al. Cost and morbidity associated with antibiotic prophylaxis in the ICU. J Am Coll Surg 1999;188:225-230. (Pubitemid 29113756)
34. Lotfi CJ, Cavalcanti Rde C, Costa e Silva AM, et al. Risk factors for surgical-site infections in head and neck cancer surgery. Otolaryngol Head Neck Surg 2008;138:74-80. (Pubitemid 350299639)
35. Barie PS, Hydo LJ, Shou J, et al. Influence of antibiotic therapy on mortality of critical surgical illness caused or complicated by infection. Surg Infect 2005;6:41-54. (Pubitemid 40711364)
36. Dominguez EA, Smith TL, Reed E, et al. A pilot study of antibiotic cycling in a hematology-oncology unit. Infect Control Hosp Epidemiol 2000;21(1 Suppl):S4-8.
37. Gutensohn A, Bunz D, Frighetto L, Jewesson P. Outcome of a ceftriaxone/cefotaxime interchange programme in a major teaching hospital. Chemotherapy 1991;37(Suppl 3):15-21.
38. Damas P, Canivet JL, Ledoux D, et al. Selection of resistance during sequential use of preferential antibiotic classes. Intensive Care Med 2006;32:67-74. (Pubitemid 43039378)
39. Martinez JA, Nicolas JM, Marco F, et al. Comparison of antimicrobial cycling and mixing strategies in two medical intensive care units. Crit Care Med 2006;34:329-336. (Pubitemid 43145609)
40. Allegranzi B, Luzzati R, Luzzani A, et al. Impact of antibiotic changes in empirical therapy on antimicrobial resistance in intensive care unit-acquired infections. J Hosp Infect 2002;52:136-140. (Pubitemid 38001944)
41. Gruson D, Hilbert G, Vargas F, et al. Rotation and restricted use of antibiotics in a medical intensive care unit: Impact on the incidence of ventilator-associated pneumonia caused by antibiotic-resistant gram-negative bacteria. Am J Respir Crit Care Med 2000;162:837-843.
42. Kollef MH, Vlasnik J, Sharpless L, et al. Scheduled change of antibiotic classes: A strategy to decrease the incidence of ventilator-associated pneumonia. Am J Respir Crit Care Med 1997;156:1040-1048.
43. Craig M, Cumpston AD, Hobbs GR, et al. The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a hematological malignancy and transplantation unit. Bone Marrow Transplant 2007;39:477-482. (Pubitemid 46605206)
44. Hughes MG, Evans HL, Chong TW, et al. Effect of an intensive care unit rotating empiric antibiotic schedule on the development of hospital-acquired infections on the non-intensive care unit ward. Crit Care Med 2004;32:53-60. (Pubitemid 38125562)
45. Dellit TH, Owens RC, McGowan JE Jr, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 2007;44:159-177. (Pubitemid 46084814)
46. Rupp ME, Marion N, Fey PD, et al. Outbreak of vancomycin-resistant Enterococcus faecium in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2001;22: 301-303. (Pubitemid 32550278)
47. Falk PS, Winnike J, Woodmansee C, et al. Outbreak of vancomycin-resistant enterococci in a burn unit. Infect Control Hosp Epidemiol 2000;21:575-582.