Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 4, 2011, Pages 1106-1113

  Rosencrantz, Marcus A ^a   Coffler, Mickey S ^a   Haggan, Annette ^a   Duke, Kimberly B ^a   Donohue, Michael C ^a   Shayya, Rana F ^a   Su, H Irene ^a   Chang, R Jeffrey ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; CHORIONIC GONADOTROPIN; ESTRADIOL; HYDROXYPROGESTERONE; PRASTERONE; PROGESTERONE; STEROID DELTA ISOMERASE; TESTOSTERONE;

ADULT; ANDROGEN SYNTHESIS; ARTICLE; BODY MASS; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; FEMALE; HUMAN; IN VITRO STUDY; OVARY POLYCYSTIC DISEASE; OVULATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SIGNAL TRANSDUCTION; STEROIDOGENESIS;

ADOLESCENT; ADULT; BODY MASS INDEX; CHORIONIC GONADOTROPIN; DEHYDROEPIANDROSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; HUMANS; HYPERANDROGENISM; INJECTIONS, INTRAVENOUS; OLIGOMENORRHEA; POLYCYSTIC OVARY SYNDROME; RECOMBINANT PROTEINS; STEROIDS; UP-REGULATION; YOUNG ADULT;

EID: 79953866981     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-2200     Document Type: Article

References (35)

1. Barnes RB, Rosenfield RL, Burstein S, EhrmannDA1989 Pituitaryovarian responses to nafarelin testing in the polycystic ovary syndrome. N Engl J Med 320:559-565 (Pubitemid 19070540)
2. Rosenfield RL, Barnes RB, Cara JF, LuckyAW1990 Dysregulation of cytochrome P450c 17 α as the cause of polycystic ovarian syndrome. Fertil Steril 53:785-791 (Pubitemid 20180464)
3. Rosenfield RL, Barnes RB, Ehrmann DA 1994 Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropinreleasing hormone agonist challenge in functional ovarian hyperandrogenism. J Clin Endocrinol Metab 79:1686-1692
4. Ehrmann DA, Barnes RB, Rosenfield RL 1995 Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev 16:322-353
5. Sahin Y, Kele̊timur F 1993 17-Hydroxyprogesterone response to buserelin testing in the polycystic ovary syndrome. Clin Endocrinol (Oxf) 39:151-155 (Pubitemid 23224284)
6. McCartney CR, Bellows AB, Gingrich MB, Hu Y, Evans WS, Marshall JC, Veldhuis JD 2004 Exaggerated 17-hydroxyprogesterone response to intravenous infusions of recombinant human LH in women with polycystic ovary syndrome. Am J Physiol Endocrinol Metab 286:E902-E908 (Pubitemid 38668811)
7. Ibañez L, Hall JE, Potau N, Carrascosa A, Prat N, Taylor AE 1996 Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin- releasing hormone (GnRH) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: Evidence from GnRH agonist and human chorionic gonadotropin stimulation testing. J Clin Endocrinol Metab 81: 4103-4107 (Pubitemid 26380424)
8. Gilling-Smith C, Story H, Rogers V, Franks S 1997 Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. Clin Endocrinol (Oxf) 47:93-99 (Pubitemid 27313994)
9. Pasquali R, Patton L, Pocognoli P, Cognigni GE, Gambineri A 2007 17-Hydroxyprogesterone responses to gonadotropin-releasing hormone disclose distinct phenotypes of functional ovarian hyperandrogenism and polycystic ovary syndrome. J Clin Endocrinol Metab 92:4208-4217 (Pubitemid 350074733)
10. Gilling-Smith C, Willis DS, Beard RW, Franks S 1994 Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries. J Clin Endocrinol Metab 79:1158-1165 (Pubitemid 24342265)
11. Nelson VL, Legro RS, Strauss 3rd JF, McAllister JM 1999 Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries. Mol Endocrinol 13: 946-957 (Pubitemid 30645312)
12. Laird NM, Ware JH 1982 Random-effects models for longitudinal data. Biometrics 38:963-974
13. Mallinckrodt CH, Clark WS, David SR 2001 Accounting for dropout bias using mixed-effects models. J Biopharm Stat 11:9-21 (Pubitemid 32642825)
14. RDevelopment CoreTeam2009 R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing
15. Koivunen RM, Morin-Papunen LC, Ruokonen A, Tapanainen JS, Martikainen HK 2001 Ovarian steroidogenic response to human chorionic gonadotropin in obese women with polycystic ovary syndrome: Effect of metformin. Hum Reprod 16:2546-2551 (Pubitemid 34007469)
16. Piltonen T, Koivunen R, Ruokonen A, Tapanainen JS 2003 Ovarian age-related responsiveness to human chorionic gonadotropin. J Clin Endocrinol Metab 88:3327-3332 (Pubitemid 36877512)
17. Trinchard-Lugan I, Khan A, Porchet HC, Munafo A 2002 Pharmacokinetics and pharmacodynamics of recombinant human chorionic gonadotropin in healthy male and female volunteers. Reprod Biomed Online 4:106-115
18. Levrant SG, Barnes RB, Rosenfield RL 1997 A pilot study of the human chorionic gonadotropin test for ovarian hyperandrogenism. Hum Reprod 12:1416-1420 (Pubitemid 27373188)
19. Piltonen T, Koivunen R, Perheentupa A, Morin-Papunen L, Ruokonen A, Tapanainen JS 2004 Ovarian age-related responsiveness to human chorionic gonadotropin in women with polycystic ovary syndrome. J Clin Endocrinol Metab 89:3769-3775 (Pubitemid 39071470)
20. Bogovich K, Richards JS 1982 Androgen biosynthesis in developing ovarian follicles: Evidence that luteinizing hormone regulates thecal 17β-hydroxylase and C17-20-lyase activities. Endocrinology 111: 1201-1208
21. Eckstein B, Greenbaum O, Cohen S 1985 Kinetic studies on ovarian C-17,20-lyase activity: Effect of luteinizing hormone surge. Endocrinology 117:2376-2382 (Pubitemid 16194064)
22. Forest MG 1979 Pattern of the response of testosterone and its precursors to human chorionic gonadotropin stimulation in relation to age in infants and children. J Clin Endocrinol Metab 49:132-137 (Pubitemid 9211975)
23. Martikainen H, Huhtaniemi I, VihkoR1980 Response of peripheral serum sex steroids and some of their precursors to a single injection of hCG in adult men. Clin Endocrinol (Oxf) 13:157-166 (Pubitemid 10053581)
24. Tapanainen J, Martikainen H, Dunkel L, Perheentupa J, Vihko R 1983 Steroidogenic response to a single injection of hCG in pre- and early pubertal cryptorchid boys. Clin Endocrinol (Oxf) 18:355-362 (Pubitemid 13158626)
25. Levrant SG, Barnes RB, Rosenfield RL, hCG-stimulated 17,20 lyase activity is unaffected by tamoxifen in PCOS or normal subjects. Program of the 76th Annual Meeting of The Endocrine Society, Anaheim, CA, 1994, p 410 (Abstract 837)
26. Lin D, Harikrishna JA, Moore CC, Jones KL, Miller WL 1991 Missense mutation serine106-proline causes 17 α-hydroxylase deficiency. J Biol Chem 266:15992-15998 (Pubitemid 21907755)
27. Lin D, Black SM, Nagahama Y, Miller WL 1993 Steroid 17 α-hydroxylase and 17,20-lyase activities of P450c17: Contributions of serine 106 and P450 reductase. Endocrinology 132:2498-2506 (Pubitemid 23156900)
28. Auchus RJ, Lee TC, Miller WL 1998 Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer. J Biol Chem 273:3158-3165 (Pubitemid 28109723)
29. Piltonen T, Koivunen R, Morin-Papunen L, Ruokonen A, Huhtaniemi IT, Tapanainen JS 2002 Ovarian and adrenal steroid production: Regulatory role of LH/HCG. Hum Reprod 17:620-624 (Pubitemid 34232430)
30. Bogovich K, Richards JS 1984 Androgen synthesis during follicular development: Evidence that rat granulosa cell 17-ketosteroid reductase is independent of hormonal regulation. Biol Reprod 31:122-131 (Pubitemid 14026861)
31. Jakubowicz DJ, Nestler JE 1997 17β-Hydroxyprogesterone responses to leuprolide and serum androgens in obese women with and without polycystic ovary syndrome offer dietary weight loss. J Clin Endocrinol Metab 82:556-560 (Pubitemid 27068628)
32. Barbieri RL, Makris A, Randall RW, Daniels G, Kistner RW, Ryan KJ 1986 Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab 62:904-910 (Pubitemid 16106715)
33. Cara JF, Rosenfield RL 1988 Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells. Endocrinology 123:733-739
34. Bergh C, Carlsson B, Olsson JH, Selleskog U, HillensjöT 1993 Regulation of androgen production in cultured human thecal cells by insulin-like growth factor I and insulin. Fertil Steril 59:323-331 (Pubitemid 23057784)
35. Nestler JE, Powers LP, Matt DW, Steingold KA, Plymate SR, Rittmaster RS, Clore JN, Blackard WG 1991 A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J Clin Endocrinol Metab 72:83-89 (Pubitemid 21921660)