High dose of N-acetylcysteine increase H2O2 and MDA levels and decrease GSH level of HUVECs exposed with malaria serum

Tropical Biomedicine

Volumn 28, Issue 1, 2011, Pages 7-15

  Fitri, L E ^a   Sardjono, T W ^a   Simamora, D ^b   Sumarno, ^a   Setyawati, S K ^a  

^a BRAWIJAYA UNIVERSITY   (Indonesia)

^b Department of Biology   (Indonesia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; HYDROGEN PEROXIDE; MALONALDEHYDE;

ARTICLE; CELL CULTURE; CHEMISTRY; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; MALARIA; METABOLISM; PATHOLOGY; SERUM;

ACETYLCYSTEINE; CELLS, CULTURED; ENDOTHELIAL CELLS; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; MALARIA; MALONDIALDEHYDE; SERUM;

EID: 79953864176     PISSN: 01275720     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Armiyanti, Y., Fitri, L.E. & Widjajanto, E. (2007). The effect of red fruit oil (Pandanus conoideus) on oxidative stress of endothelial cells exposed to malaria falciparum patient serum and healthy donor neutrophyl. Medical Journal of Brawijaya 23(1): 6-14.
2. Atamna, H. & Ginsburg, H. (1997). The malaria parasite supplies glutathione to its host cell. Investigation of glutathione transport and metabolism in human erythrocytes infected with Plasmodiun falciparum. European Journal of Biochemistry 250: 670-679.
3. Clark, I.A., Budd, A.C., Alleva, M.L. & Cowden, W.B. (2006). Human malaria disease: a consequence of inflammatory cytokine release. Malaria Journal 5: 85. http://www.malariajournal.com/content/5/1/85.
4. Daly, F.F.S., Fountain, J.S., Murray, L., Graudins, A. & Buckley, N.A. (2008). Guidelines for the management of paracetamol poisoning in Australia and New Zealand - explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres. Medical Journal of Australia 188(5): 296-301.
5. Draper, H. & Hadley, M. (1990). Malondialdehyde determination as index of lipid peroxidation. Methods in Enzymology 186: 421-431.
6. Dondorp, A.M. (2005). Pathophysiology, clinical presentation, and treatment of cerebral malaria. Neurology Asia 10: 67-77.
7. Favier, A.E. (1995). How to demonstrate the occurrence of an oxidative stress in human?. Analysis of Free Radical in Biological System. Birkhausel Verlag Basel, Switzerland, pp 99-116.
8. Flanagan, R.J. & Meredith, T.J. (1991). Use of N-acetylcysteine in clinical toxicology. American Journal of Medicine 91(Suppl C): 131S-139S.
9. Fitri, L.E., Suhendro, W., Murwani, S., Muliartha, I.K.G. & Ali, M. (2003). Effect of combined therapy using choroquine and vitamin C to the peritoneal macrophage function on Balb/C strain mice infected by Plasmodium berghei. Medical Journal of Brawijaya 19(3): 99-103.
10. Fitri, L.E., Soebaktiningsih, Widodo, M.A., Sumarno & Supargiyono. (2006). Correlation between cytoadherence, nitric oxide, hydrogen peroxide and clinical manifestation of severe malaria. Journal of Indonesian Medical Association 56(12): 674-682.
11. Fitri, L.E. (2006). Expression of inducible nitric oxide synthase, caspase-3 and production of reactive oxygen intermediate on endothelial cells culture (HUVECs) treated with P. falciparum infected erythrocytes and tumor necrosis factor α. Medical Journal of Indonesia 15: 151-156.
12. Fitri, L.E., Iskandar, A., Permatasari, A., Addi, A., Nihayati, Z. (2008). The effect of artemisinin and N-acetylcysteine (NAC) combination toward liver and kidney malonyldialdehyde (MDA) level on mice infected with Plasmodium berghei. Medical Journal of Brawijaya 24(2): 73-78.
13. Grimble, R.F. (2006). The effects of sulfur amino acid intake on immune function in human. The American Society for Nutrition. Journal Nutrition 136: 1660s-1665s.
14. Halliwell, B. & Gutteridge, J.M.C. (1999). Free Radicals in Biology and Medicine. Third edition. Oxford sciences publication, New York, pp 544-609.
15. Hemmer, C.J., Lehr, H.A., Westphal, K., Unvericht, M., Kratzius, M. & Reisinger, E.C. (2005). Plasmodium falciparum malaria: Reduction of endothelial cells apoptosis in vitro. Infection and Immunity 73(3): 1764-1770.
16. Hunt, N.H., Kopp, M. & Stocker, R. (1992). Free Radicals and antioxidant in malaria in Lipid- Soluble Antioxidant: Biochemistry and Clinical Applications, Ong, A.S.H. & Packer, L. (Editors) pp 337-354, Birkhauser Verlag, Switzerland.
17. Iskandar, A. (2005). Synergistic effects chloroquine and N-acetylcysteine on reducing free radical activity of erythrocytes and increased phagocytosis activity of peritoneal magrofag mice Balb/C infected Plasmodium berghei. Thesis. Postgraduate Program Brawijaya University. Malang.
18. Kerksick, C. & Willoughby. (2005). The antioxidant role of glutathione and N-acetylcysteine supplements and exercise-induced oxidative stress. Journal of the International Society of Sports Nutrition 2: 38-44.
19. Kim, Y.J. (2007). Culture of umbilical cord and cord blood derived stem cells. Editor Freshney, R.I., Stacey, G.N., Auerbach, J.M. Wiley Inter-science a John Wiley & Sons. pp159-186.
20. Mohanty, S., Patel, D.K., Pati, S.S. & Mishra, S.K. (2006). Adjuvant therapy in cerebral malaria. Indian Journal of Medical Research 124(9): 245-26.
21. Nanda, R., Mishra, P.K., Das, U.K., Rout, S.B., Mohapatra, P.C. & Panda, A. (2004). Evaluating role of oxidative stress, in determining the pathogenesis of falciparum malaria induced acute renal failure. Indian Journal of Clinical Biochemistry 19(1): 93-96.
22. Ortolani, O., Conti, A., Gaudio, A.R.D., Moraldi, E., Cantini, Q. & Novelli, G. (2000). The effect of gluthatione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. American Journal of Respiratory and Critical Care Medicine 161: 1907-1911.
23. Pino, P., Vouldoukis, I., Dugas, N., Hassani-Loppion, G., Dugas, B. & Mazier D. (2003). Redox dependent apoptosis in human endothelial cells after adhesion of Plasmodium falciparum infected erythrocytes. Annal Of The New York Academy of Science 1010: 582-586.
24. Sagristá, M.L., GarcÍa, A.F., Madariaga, M.A.D. & Mora. (2002). Antioxidant and pro-oxidant effect of the thiolic compounds N -acetyl- l -cysteine and glutathione against free radicalinduced lipid peroxidation. Free Radical Research 36(3): 329-340.
25. Silamut, K., Phu, N.H., Whitty, C., Turner, G.D.H., Louwrier, K., May, N.T.H., Simpson, J.A., Hien, T.T. & White, N.J. (1999). A quantitative analysis on the microvascular sequestration of malaria parasite in the human brain. American Journal of Pathology 155(2): 395-410.
26. Staal, F.J.T., Roederer, M., Anderson, M.T., & Herzenberg, L.A. (1993). Redox regulation of NFkβ activation and therefore HIV expression In Nariuchi & Hideo, Molecular Basis of Immune Responses. Academic Press. Copyright by The Ryoichi Naito Foundation for Medical Research.
27. Treeprasertsuk, S., Kruudsood, S., Tosukhowong, T., Maek-A-Nantawat, W., Vannaphan, S., Saengnetswang, T., Looareesuwan, S., Kuhn, W.F., Brittenham, G. & Carroll, J. (2003). Nacetylcysteine in severe falciparum malaria in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health 34(1): 37-42.
28. Turner, G.D.H., Morrison, H., Jones, M., Davis, T.M.E., Looareesuwan, S., Buley, I.D., Gatter, K.C., Newbold, C.I., Pukritayakamee, S., Nagachinta, B., White, N.J. & Berendt, A.R. (1994). An immunohistochemical study of the pathology of fatal malaria: evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. American Journal of Pathology 145(5): 1057-1069.
29. Watt, G., Jongsakul, K. & Ruangvirayuth, R. (2002). A pilot study of N-acetylcysteine as adjunctive therapy for severe malaria. Quarterly Journal of Medicine 95: 285-290.
30. Yogiantoro, M., Thaha, M. & Tomino, Y. (2006). Intravenous N-acetylcysteine during haemodialysis reduces plasma concentration of homocysteine in patient with end-stage renal disease. Clinical Drug Investigatation 26(4): 195-202.
31. Zimmerman, R.J., Marafino, B.J., Chan, A., Landre, P. & Winkelhake, J.L. (1989). The role of oxidant injury in tumor cell sensitivity to recombinant human tumor necrosis factor in vivo. Journal of Immunology 142: 1409-1409.