mef(A) is the predominant macrolide resistance determinant in Streptococcus pneumoniae and Streptococcus pyogenes in Germany

International Journal of Antimicrobial Agents

Volumn 37, Issue 5, 2011, Pages 425-431

  Bley, Christine ^a   Van Der Linden, Mark ^a   Reinert, Ralf René ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Epidemiology; erm(B) gene; mef gene; MLST; Resistance

Indexed keywords

ANTIBIOTIC AGENT; CEFOTAXIME; CLARITHROMYCIN; CLINDAMYCIN; ERYTHROMYCIN; LEVOFLOXACIN; MACROLIDE; PENICILLIN G; ROKITAMYCIN; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATION; CONTROLLED STUDY; ERM(A); ERM(B); GENE SEQUENCE; GERMANY; MEF(A); MEF(E); MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; UNITED KINGDOM;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BACTERIAL TYPING TECHNIQUES; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, BACTERIAL; GENOTYPE; GERMANY; HUMANS; INFANT; INFANT, NEWBORN; MACROLIDES; MEMBRANE PROTEINS; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MULTILOCUS SEQUENCE TYPING; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; YOUNG ADULT;

EID: 79953859093     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2011.01.019     Document Type: Article

References (34)

1. Musher DM. Infections caused by Streptococcus pneumoniae: clinical spectrum, pathogenesis, immunity, and treatment. Clin Infect Dis 1992;14:801-7.
2. Reinert RR, Lütticken R, Bryskier A, Al-Lahham A. Macrolide-resistant Streptococcus pneumoniae and Streptococcus pyogenes in the pediatric population in Germany during 2000-2001. Antimicrob Agents Chemother 2003;47:489-93.
3. Reinert RR. Clinical efficacy of ketolides in the treatment of respiratory tract infections. J Antimicrob Chemother 2004;53:918-27. (Pubitemid 38807631)
4. Van Bambeke F, Reinert RR, Appelbaum PC, Tulkens PM, Peetermans WE. Multidrug-resistant Streptococcus pneumoniae infections: current and future therapeutic options. Drugs 2007;67:2355-82. (Pubitemid 350071047)
5. Montanari MP, Mingoia M, Cochetti I, Varaldo PE. Phenotypes and genotypes of erythromycin-resistant pneumococci in Italy. J Clin Microbiol 2003;41:428-31. (Pubitemid 36098612)
6. Zhong P, Shortridge VD. The role of efflux in macrolide resistance. Drug Resist Updat 2000;3:325-9. (Pubitemid 32118398)
7. Gay K, Stephens DS. Structure and dissemination of a chromosomal insertion element encoding macrolide efflux in Streptococcus pneumoniae. J Infect Dis 2001;184:56-65. (Pubitemid 32568501)
8. Santagati M, Iannelli F, Oggioni MR, Stefani S, Pozzi G. Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae. Antimicrob Agents Chemother 2000;44:2585-7. (Pubitemid 30650926)
9. Del Grosso M, Iannelli F, Messina C, Santagati M, Petrosillo N, Stefani S, et al. Macrolide efflux genes mef(A) and mef(E) are carried by different genetic elements in Streptococcus pneumoniae. J Clin Microbiol 2002;40:774-8. (Pubitemid 34208622)
10. Leclercq R, Courvalin P. Resistance to macrolides and related antibiotics in Streptococcus pneumoniae. Antimicrob Agents Chemother 2002;46:2727-34.
11. Del Grosso M, Camilli R, Iannelli F, Pozzi G, Pantosti A. The mef(E)-carrying genetic element (MEGA) of Streptococcus pneumoniae: insertion sites and association with other genetic elements. Antimicrob Agents Chemother 2006;50:3361-6. (Pubitemid 44527511)
12. Cochetti I, Tili E, Vecchi M, Manzin A, Mingoia M, Varaldo PE, et al. New Tn916-related elements causing erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci. J Antimicrob Chemother 2007;60:127-31. (Pubitemid 47073285)
13. Seppala H, Skurnik M, Soini H, Roberts MC, Huovinen P. A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes. Antimicrob Agents Chemother 1998;42:257-62. (Pubitemid 28114428)
14. Roberts MC, Sutcliffe J, Courvalin P, Jensen LB, Rood J, Seppälä H. Nomenclature for macrolide and macrolide-lincosamide- streptogramin B resistance determinants. Antimicrob Agents Chemother 1999;43:2823-30.
15. Canu A, Malbruny B, Coquemont M, Davies TA, Appelbaum PC, Leclercq R. Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae. Antimicrob Agents Chemother 2002;46:125-31. (Pubitemid 34031613)
16. Imohl M, Reinert RR, Ocklenburg C, van der Linden M. Association of serotypes of Streptococcus pneumoniae with age in invasive pneumococcal disease. J Clin Microbiol 2010;48:1291-6.
17. Reinert RR, Franken C, van der Linden M, Lutticken R, Cil M, Al-Lahham A. Molecular characterisation of macrolide resistance mechanisms of Streptococcus pneumoniae and Streptococcus pyogenes isolated in Germany, 2002-2003. Int J Antimicrob Agents 2004;24:43-7.
18. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; eighteenth informational supplement. Document M100-S18. Wayne, PA: CLSI; 2008.
19. Giovanetti E, Montanari MP, Mingoia M, Varaldo PE. Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains in Italy and heterogeneity of inducibly resistant strains. Antimicrob Agents Chemother 1999;43:1935-40. (Pubitemid 29395189)
20. de la Pedrosa EG, Morosini MI, van der Linden M, Ruiz-Garbajosa P, Galan JC, Baquero F, et al. Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm(B). Antimicrob Agents Chemother 2008;52:1964-9. (Pubitemid 351758531)
21. Sutcliffe J, Grebe T, Tait-Kamradt A, Wondrack L. Detection of erythromycin-resistant determinants by PCR. Antimicrob Agents Chemother 1996;40:2562-6. (Pubitemid 26367644)
22. Neufeld F. Über die Agglutination der Pneumokokken und über die Theorie der Agglutination. Zeitschrift für Hygiene und Infektionskrankheiten 1902;34:54-72.
23. Enright MC, Spratt BG. A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology 1998;144:3049-60. (Pubitemid 28515583)
24. Reinert RR, Al-Lahham A, Lemperle M, Tenholte C, Briefs C, Haupts S, et al. Emergence of macrolide and penicillin resistance among invasive pneumococcal isolates in Germany. J Antimicrob Chemother 2002;49:61-8. (Pubitemid 34100648)
25. 14-5 Streptococcus pneumoniae clone over a 22 year period. J Antimicrob Chemother 2004;53:620-5.
26. Cornaglia G, Ligozzi M, Mazzariol A, Masala L, Lo Cascio G, Orefici G, et al. Resistance of Streptococcus pyogenes to erythromycin and related antibiotics in Italy. The Italian Surveillance Group for Antimicrobial Resistance. Clin Infect Dis 1998;27(Suppl. 1):S87-92.
27. Sauermann R, Gattringer R, Graninger W, Buxbaum A, Georgopoulos A. Phenotypes of macrolide resistance of group A streptococci isolated from outpatients in Bavaria and susceptibility to 16 antibiotics. J Antimicrob Chemother 2003;51:53-7. (Pubitemid 36163827)
28. Reinert RR, Ringelstein A, van der Linden M, Cil MY, Al-Lahham A, Schmitz FJ. Molecular epidemiology of macrolide-resistant Streptococcus pneumoniae isolates in Europe. J Clin Microbiol 2005;43:1294-300. (Pubitemid 40364953)
29. Wierzbowski AK, Swedlo D, Boyd D, Mulvey M, Nichol KA, Hoban DJ, et al. Molecular epidemiology and prevalence of macrolide efflux genes mef(A) and mef(E) in Streptococcus pneumoniae obtained in Canada from 1997 to 2002. Antimicrob Agents Chemother 2005;49:1257-61.
30. Imohl M, Reinert RR, Ocklenburg C, van der Linden M. Epidemiology of invasive Streptococcus pyogenes disease in Germany during 2003-2007. FEMS Immunol Med Microbiol 2010;58:389-96.
31. McGee L, Klugman KP, Wasas A, Capper T, Brink A. Serotype 19F multiresistant pneumococcal clone harboring two erythromycin resistance determinants (erm(B) and mef(A)) in South Africa. Antimicrob Agents Chemother 2001;45:1595-8. (Pubitemid 32374145)
32. Farrell DJ, Jenkins SG, Brown SD, Patel M, Lavin BS, Klugman KP. Emergence and spread of Streptococcus pneumoniae with erm(B) and mef(A) resistance. Emerg Infect Dis 2005;11:851-8. (Pubitemid 40720845)
33. Del Grosso M, Northwood JG, Farrell DJ, Pantosti A. The macrolide resistance genes erm(B) and mef(E) are carried by Tn2010 in dual-gene Streptococcus pneumoniae isolates belonging to clonal complex CC271. Antimicrob Agents Chemother 2007;51:4184-6. (Pubitemid 350057826)
34. Klaassen CH, Mouton JW. Molecular detection of the macrolide efflux gene: to discriminate or not to discriminate between mef(A) and mef(E). Antimicrob Agents Chemother 2005;49:1271-8.