In vitro activity of new artemisinin derivatives against Plasmodium falciparum clinical isolates from Gabon

International Journal of Antimicrobial Agents

Volumn 37, Issue 5, 2011, Pages 485-488

  Held, Jana ^a,b   Soomro, Shahid A ^c   Kremsner, Peter G ^a,b   Jansen, F Herwig ^c   Mordmüller, Benjamin ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b ALBERT SCHWEITZER HOSPITAL   (Gabon)

^c Dafra Pharma nv   (Belgium)

Author keywords

Artemisinin; Malaria; Plasmodium falciparum

Indexed keywords

ARTEMISININ DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; GABON; IC 50; IN VITRO STUDY; NONHUMAN; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRAIN IDENTIFICATION; STRUCTURE ANALYSIS;

ADOLESCENT; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; GABON; HUMANS; INFANT; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM;

EID: 79953851731     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2010.12.022     Document Type: Article

References (15)

1. Woodrow CJ, Haynes RK, Krishna S. Artemisinins. Postgrad Med J 2005;81:71-8.
2. Skinner TS, Manning LS, Johnston WA, Davis TM. In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs. Int J Parasitol 1996;26:519-25.
3. Klayman DL. Qinghaosu (artemisinin): an antimalarial drug from China. Science 1985;228:1049-55. (Pubitemid 15227365)
4. Jansen FH, Soomro SA. Chemical instability determines the biological action of the artemisinins. Curr Med Chem 2007;14:3243-59.
5. Haynes RK, Chan HW, Lung CM, Ng NC, Wong HN, Shek LY, et al. Artesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug. ChemMedChem 2007;2:1448-63.
6. Borrmann S, Adegnika AA, Missinou MA, Binder RK, Issifou S, Schindler A, et al. Short-course artesunate treatment of uncomplicated Plasmodium falciparum malaria in Gabon. Antimicrob Agents Chemother 2003;47:901-4. (Pubitemid 36254213)
7. Kremsner PG, Krishna S. Antimalarial combinations. Lancet 2004;364:285-94.
8. White NJ. Delaying antimalarial drug resistance with combination chemotherapy. Parassitologia 1999;41:301-8.
9. Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med 2008;359:2619-20.
10. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, et al. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 2009;361:455-67.
11. Soomro S, Konkimalla VB, Langenberg T, Mahringer A, Horwedel C, Holenya P, et al. Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties. J Cell Mol Med 2010, doi:10.1111/j.1582-4934.2010. 01120.x.
12. Noedl H, Bronnert J, Yingyuen K, Attlmayr B, Kollaritsch H, Fukuda M. Simple histidine-rich protein 2 double-site sandwich enzyme-linked immunosorbent assay for use in malaria drug sensitivity testing. Antimicrob Agents Chemother 2005;49:3575-7. (Pubitemid 41060624)
13. Ritz C, Streibig JC. Bioassay analysis using R. J Stat Software 2005;12.
14. R Development Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2009.
15. Borrmann S, Binder RK, Adegnika AA, Missinou MA, Issifou S, Ramharter M, et al. Reassessment of the resistance of Plasmodium falciparum to chloroquine in Gabon: implications for the validity of tests in vitro vs. in vivo. Trans R Soc Trop Med Hyg 2002;96:660-3. (Pubitemid 36231492)