Influence of residual normal metaphases in acute myeloid leukemia patients with monosomal karyotype

Haematologica

Volumn 96, Issue 4, 2011, Pages 631-632

  Xie, Bin ^a,d   Othus, Megan ^a,b   Medeiros, Bruno C ^c   Fang, Min ^a,d   Appelbaum, Frederick R ^a,d   Estey, Elihu H ^a,d  

^a Fred Hutchinson Cancer Research Center   (United States)

^b SOUTHWEST ONCOLOGY GROUP STATISTICAL CENTER   (United States)

^c STANFORD CANCER INSTITUTE   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Acute myeloid leukemia; Cytogenetics; Monosomal karyotype; Normal metaphases; Overall survival

Indexed keywords

CYTARABINE;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; CANCER PATIENT; CANCER SURVIVAL; CYTOGENETICS; DEATH; FEMALE; HUMAN; HUMAN CELL; KARYOTYPE; LETTER; MAJOR CLINICAL STUDY; MALE; METAPHASE; MINIMAL RESIDUAL DISEASE; MONOSOMY; STRUCTURAL CHROMOSOME ABERRATION; SUPERNUMERARY CHROMOSOME; SURVIVAL RATE; TREATMENT DURATION; TREATMENT RESPONSE;

HUMANS; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; METAPHASE; MONOSOMY;

EID: 79953844394     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.037838     Document Type: Letter

References (7)

1. Byrd JC, Mrozek K, Dodge RK, Carroll AJ, Edwards CG, Arthur DC, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. 2002;100(13):4325-4336.
2. Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 1998;92(7):2322-2333.
3. Mrozek K, Bloomfield CD. Chromosome aberrations, gene mutations and expression changes, and prognosis in adult acute myeloid leukemia. Hematology Am Soc Hematol Educ Program. 2006;169-177.
4. Mrozek K, Heerema NA, Bloomfield CD. Cytogenetics in acute leukemia. Blood Rev. 2004;18(2):115-136.
5. Breems DA, Van Putten WL, De Greef GE, Van Zelderen-Bhola SL, Gerssen-Schoorl KB, Mellink CH, et al. Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol. 2008;26(29):4791-4797.
6. Medeiros BC, Othus M, Fang M, Roulston D, Appelbaum FR. Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group experience. Blood. 2010;116(13):2224-2228.
7. Estey EH, Pierce S, Keating MJ. Identification of a group of AML/MDS patients with a relatively favorable prognosis who have chromosome 5 and/or 7 abnormalities. Haematologica. 2000;85(3):246-249.