Effect of sex and pregnancy on the potency of intrathecal bupivacaine: Determination of ED50 for motor block with the up-down sequential allocation method

European Journal of Anaesthesiology

Volumn 28, Issue 4, 2011, Pages 240-244

  Camorcia, Michela ^a   Capogna, Giorgio ^a   Columb, Malachy O ^b  

^a Citta di Roma Hospital   (Italy)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Anesthesia; Bupivacaine motor block; Subarachnoid local anesthetic

Indexed keywords

BUPIVACAINE;

ADULT; ARTICLE; CESAREAN SECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG POTENCY; ELECTIVE SURGERY; EPIDURAL ANESTHESIA; FEMALE; HUMAN; MALE; MOTOR NERVE BLOCK; PREGNANCY; PREGNANT WOMAN; PROSPECTIVE STUDY; SEX DIFFERENCE; SPINAL ANESTHESIA;

ADULT; ANALYSIS OF VARIANCE; ANESTHESIA, OBSTETRICAL; ANESTHESIA, SPINAL; ANESTHETICS, LOCAL; BUPIVACAINE; CESAREAN SECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INJECTIONS, SPINAL; LOGISTIC MODELS; MALE; MOTOR ACTIVITY; NERVE BLOCK; ORTHOPEDIC PROCEDURES; PREGNANCY; PROSPECTIVE STUDIES; ROME; SENSORY THRESHOLDS; SEX FACTORS; SURGICAL PROCEDURES, ELECTIVE; TIME FACTORS;

EID: 79953842899     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e3283405163     Document Type: Article

References (26)

1. Pleym H, Spigset O, Kharasch ED, et al. Gender differences in drug effects: Implications for anesthesiologists. Acta Anaesthesiol Scand 2003; 47:241-259. (Pubitemid 36384661)
2. Bromage PR. Spread of analgesic solutions in the epidural space and their site of action: A statistical study. Br J Anaesth 1962; 34:161-178.
3. Fagraeus L, Urban BJ, Bromage PR. Spread of epidural analgesia in early pregnancy. Anesthesiology 1983; 58:184-187. (Pubitemid 13183939)
4. Sharma K, Batra YK, Singh H. Effect of decreased cerebrospinal fluid proteins on the spread of local anaesthetic drugs in pregnancy. Indian J Med Res 1990; 92:175-177.
5. Datta S, Lambert DH, Gregus J, et al. Differential sensitivities of mammalian nerve fibers during pregnancy. Anesth Analg 1983; 62:1070-1072. (Pubitemid 14202786)
6. Fassoulaki A, Gatzu V, Petropoulos G, Siafaka I. Spread of subarachnoid block, intraoperative local anaesthetic requirements and postoperative analgesic requirements in caesarean section and total abdominal hysterectomy. Br J Anaesth 2004; 93:678-682. (Pubitemid 39445549)
7. Dietz FB, Jaffe RA. Pregnancy does not increase susceptibility to bupivacaine in spinal root axons. Anesthesiology 1997; 87:610-616. (Pubitemid 27433011)
8. Arakawa M. Does pregnancy increase the efficacy of lumbar epidural anesthesia? Int J Obstet Anesth 2004; 13:86-90. (Pubitemid 38364839)
9. Columb MO, D'Angelo R. Up-down studies: Responding to dosing!. Int J Obstet Anesth 2006; 15:129-136.
10. Camorcia M, Capogna G, Berritta C, Columb M. The relative potencies for motor block after intrathecal bupivacaine, levobupivacaine and ropivacaine. Anesth Analg 2007; 104:904-907. (Pubitemid 46548319)
11. Plaat F. Ambulatory analgesia in labour. In: Collis R, Plaat F, Urquat J, editors. Textbook of obstetric anaesthesia. London: GMM; 2002. p. 108.
12. Dixon WJ, Massey FJ. Introduction to statistical analysis. 4th Ed. New York: McGraw-Hill; 1983. pp. 428-439.
13. Camorcia M, Capogna G, Lyons G, Columb M. Epidural test dose with levobupivacaine and ropivacaine: Determination of the ED50 for motor block after spinal administration. Br J Anaesth 2004; 92:850-853. (Pubitemid 38771687)
14. Sun LS. Gender differences in pain sensitivity and responses to analgesia. J Gend Specif Med 1998; 1:28-30.
15. Morin C, Lund JP, Villarroel T, et al. Differences between the sexes in postsurgical pain. Pain 2000; 85:79-85.
16. Taivainen T, Tuominen M, Rosenberg PH. Influence of obesity on the spread of spinal analgesia after injection of plain 0.5% bupivacaine at the L3-4 or L4-5 interspace. Br J Anaesth 1990; 64:542-546. (Pubitemid 20157943)
17. Panni MK, Columb MO. Obese parturients have lower local anaesthetic requirements for analgesia in labour. Br J Anaesth 2006; 96:106-110. (Pubitemid 43124540)
18. Ekelof NP, Jensen E, Poulsen J, Reinstrup P. Weight gain during pregnancy does not influence the spread of spinal analgesia in the term parturient. Acta Anaesthesiol Scand 1997; 41:884-887. (Pubitemid 27317715)
19. Wong CA, Cariaso D, Johnson EC, et al. Body habitus does not influence spread of sensory blockade after the intrathecal injection of a hypobaric solution in term parturients. Can J Anaesth 2003; 50:689-693. (Pubitemid 37321974)
20. McLennan CE. Antecubital and femoral venous pressure in normal and toxemic pregnancy. Am J Obstet Gynecol 1943; 45:568-591.
21. Kaneko M, Saito Y, Kirihara Y, Kosaka Y. Pregnancy enhances the antinociceptive effects of extradural lignocaine in the rat. Br J Anaesth 1994; 72:657-661. (Pubitemid 24172228)
22. JayaramA, Carp H. Progesterone-mediated potentiation of spinal sufentanil in rats. Anesth Analg 1993; 76:745-750. (Pubitemid 23107590)
23. Bader AM, Datta S, Moller RA, Covino BG. Acute progesterone treatment has no effect on bupivacaine-induced conduction blockade in the isolated rabbit vagus nerve. Anesth Analg 1990; 71:545-548. (Pubitemid 20380606)
24. Butterworth JF, Walker FO, Lysak SZ. Pregnancy increases median nerve susceptibility to lidocaine. Anesthesiology 1990; 72:962-965. (Pubitemid 20204650)
25. Hirabayashi Y, Shimizu R, Saitoh K, et al. Acid-base state of cerebrospinal fluid during pregnancy and its effect on spread of spinal anaesthesia. Br J Anaesth 1996; 77:352-355. (Pubitemid 26300861)
26. Datta S, Hurley RJ, Naulty JS, et al. Plasma and cerebrospinal fluid progesterone concentrations in pregnant and nonpregnant women. Anesth Analg 1986; 65:950-954. (Pubitemid 16040110)