Improved functional recovery after facial nerve reconstruction by temporary denervation of the contralateral mimic musculature with botulinum toxin in rat

Neurorehabilitation and Neural Repair

Volumn 25, Issue 1, 2011, Pages 15-23

  Guntinas Lichius, Orlando ^a   Glowka, Tim R ^b,c   Angelov, Doychin N ^c   Irintchev, Andrey ^a   Neiss, Wolfram F ^c  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Botulinum toxin; Constraint induced therapy; Facial nerve regeneration; Fluorescence tracing; Rat; Suture; Whisking

Indexed keywords

BOTULINUM TOXIN;

ARTICLE; CONTROLLED STUDY; DENERVATION; FACIAL NERVE; FEMALE; FLUORESCENCE ANALYSIS; GENERAL CONDITION IMPROVEMENT; NERVE ANASTOMOSIS; NERVE RECONSTRUCTION; NERVE REGENERATION; NONHUMAN; PARALYSIS; RAT; REINNERVATION; VIBRISSA;

ANALYSIS OF VARIANCE; ANASTOMOSIS, SURGICAL; ANIMALS; AXONS; BOTULINUM TOXINS, TYPE A; BUNGAROTOXINS; DISEASE MODELS, ANIMAL; FACIAL NERVE INJURIES; FEMALE; FUNCTIONAL LATERALITY; MOTOR NEURONS; MUSCLE DENERVATION; NERVE REGENERATION; NEUROMUSCULAR AGENTS; RATS; RATS, WISTAR; RECEPTORS, CHOLINERGIC; RECOVERY OF FUNCTION; TIME FACTORS; VIBRISSAE;

EID: 79953841946     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968310376058     Document Type: Article

References (31)

1. Guntinas-Lichius O, Streppel M, Stennert E. Postoperative functional evaluation of different reanimation techniques for facial nerve repair. Am J Surg. 2006;191:61-67. (Pubitemid 43042522)
2. Anonsen CK, Trachy RE, Hibbert J, Cummings CW. Assessment of facial reinnervation by use of chronic electromyographic monitoring. Otolaryngol Head Neck Surg. 1986;94: 32-36. (Pubitemid 16129883)
3. Guntinas-Lichius O, Irintchev A, Streppel M, et al. Factors limiting motor recovery after facial nerve transection in the rat: combined structural and functional analyses. Eur J Neurosci. 2005;21:391-402. (Pubitemid 40204242)
4. Eccles JC, Libet B, Young RR. The behaviour of chromatolysed motoneurones studied by intracellular recording. J Physiol. 1958;143:11-40.
5. Titmus MJ, Faber DS. Axotomy-induced alterations in the electrophysiological characteristics of neurons. Prog Neurobiol. 1990;35:1-51. (Pubitemid 20228553)
6. Lieberman AR. The axon reaction: a review of the principal features of perikaryal responses to axon injury. Int Rev Neurobiol. 1971;14:49-124.
7. Blinzinger K, Kreutzberg G. Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Z Zellforsch Mikrosk Anat. 1968;85:145-157.
8. Angelov DN, Skouras E, Guntinas-Lichius O, et al. Contralateral trigeminal nerve lesion reduces polyneuronal muscle innervation after facial nerve repair in rats. Eur J Neurosci. 1999;11:1369-1378. (Pubitemid 29142196)
9. Skouras E, Popratiloff A, Guntinas-Lichius O, et al. Altered sensory input improves the accuracy of muscle reinnervation. Restor Neurol Neurosci. 2002;20:1-14. (Pubitemid 35253691)
10. Guntinas-Lichius O, Hundeshagen G, Paling T, Angelov DN. Impact of different types of facial nerve reconstruction on the recovery of motor function: an experimental study in adult rats. Neurosurgery. 2007;61:1276-1283; discussion 1283-1285.
11. Popratiloff AS, Neiss WF, Skouras E, Streppel M, Guntinas- Lichius O, Angelov DN. Evaluation of muscle re-innervation employing pre- and post-axotomy injections of fluorescent retrograde tracers. Brain Res Bull. 2001;54:115-123. (Pubitemid 32156922)
12. Dohm S, Streppel M, Guntinas-Lichius O, et al. Local application of extracellular matrix proteins fails to reduce the number of axonal branches after varying reconstructive surgery on rat facial nerve. Restor Neurol Neurosci. 2000;16:117-126. (Pubitemid 30159157)
13. Gundersen HJ, Bagger P, Bendtsen TF, et al. The new stereological tools: dissector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS. 1988;96:857-881.
14. Dorfl J. The innervation of the mystacial region of the white mouse: a topographical study. J Anat. 1985;142:173-184. (Pubitemid 16244295)
15. Guntinas-Lichius O, Angelov DN, Tomov TL, Dramiga J, Neiss WF, Wewetzer K. Transplantation of olfactory ensheathing cells stimulates the collateral sprouting from axotomized adult rat facial motoneurons. Exp Neurol. 2001;172:70-80. (Pubitemid 33141155)
16. Tomov TL, Guntinas-Lichius O, Grosheva M, et al. An example of neural plasticity evoked by putative behavioral demand and early use of vibrissal hairs after facial nerve transection. Exp Neurol. 2002;178:207-218. (Pubitemid 36062631)
17. Guntinas-Lichius O, Wewetzer K, Tomov TL, et al. Transplantation of olfactory mucosa minimizes axonal branching and promotes the recovery of vibrissae motor performance after facial nerve repair in rats. J Neurosci. 2002;22:7121-7131. (Pubitemid 35379167)
18. Haastert K, Grosheva M, Angelova SK, et al. Schwann cells overexpressing FGF-2 alone or combined with manual stimulation do not promote functional recovery after facial nerve injury. J Biochem Biotechnol. 2009;2009:408794.
19. Angelov DN, Ceynowa M, Guntinas-Lichius O, et al. Mechanical stimulation of paralyzed vibrissal muscles following facial nerve injury in adult rat promotes full recovery of whisking. Neurobiol Dis. 2007;26:229-242. (Pubitemid 46442790)
20. Cossu G, Valls-Sole J, Valldeoriola F, Munoz E, Benitez P, Aguilar F. Reflex excitability of facial motoneurons at onset of muscle reinnervation after facial nerve palsy. Muscle Nerve. 1999;22:614-620. (Pubitemid 29214428)
21. Peeva GP, Angelova SK, Guntinas-Lichius O, et al. Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticity. Eur J Neurosci. 2006;24: 2152-2162. (Pubitemid 44622336)
22. Sadjadpour K. Postfacial palsy phenomena: faulty nerve regeneration or ephaptic transmission? Brain Res. 1975;95:403-406.
23. Sanes JN, Suner S, Donoghue JP. Dynamic organization of primary motor cortex output to target muscles in adult rats. I. Long-term patterns of reorganization following motor or mixed peripheral nerve lesions. Exp Brain Res. 1990;79: 479-491. (Pubitemid 20107747)
24. Franchi G. Time course of motor cortex reorganization following botulinum toxin injection into the vibrissal pad of the adult rat. Eur J Neurosci. 2002;16:1333-1348. (Pubitemid 35340857)
25. Dimyan MA, Cohen LG. Contribution of transcranial magnetic stimulation to the understanding of functional recovery mechanisms after stroke. Neurorehabil Neural Repair. 2010;24:125-135.
26. O'Shea J, Johansen-Berg H, Trief D, Gobel S, Rushworth MF. Functionally specific reorganization in human premotor cortex. Neuron. 2007;54:479-490. (Pubitemid 46659815)
27. Meunier FA, Schiavo G, Molgo J. Botulinum neurotoxins: from paralysis to recovery of functional neuromuscular transmission. J Physiol. 2002;96:105-113. (Pubitemid 34087038)
28. Simpson DM, Blitzer A, Brashear A, et al. Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2008;70:1699-1706. (Pubitemid 351644138)
29. Franchi G, Veronesi C. Short-term reorganization of inputdeprived motor vibrissae representation following motor disconnection in adult rats. J Physiol. 2006;574:457-476.
30. Pavlov SP, Grosheva M, Streppel M, et al. Manually-stimulated recovery of motor function after facial nerve injury requires intact sensory input. Exp Neurol. 2008;211:292-300.
31. Swayne O, Rothwell J, Rosenkranz K. Transcallosal sensorimotor integration: effects of sensory input on cortical projections to the contralateral hand. Clin Neurophysiol. 2006;117: 855-863.