Double-blind, placebo-controlled antibiotic treatment study of small intestinal bacterial overgrowth in children with chronic abdominal pain

Journal of Pediatric Gastroenterology and Nutrition

Volumn 52, Issue 4, 2011, Pages 382-386

  Collins, Brynie Slome ^a   Lin, Henry C ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NEW MEXICO VA HEALTH CARE SYSTEM   (United States)

Author keywords

chronic abdominal pain; functional abdominal pain; functional dyspepsia; irritable bowel syndrome; small intestinal bacterial overgrowth

Indexed keywords

RIFAXIMIN;

ABDOMINAL PAIN; ADOLESCENT; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL OVERGROWTH; BREATH ANALYSIS; CHILD; CHRONIC PAIN; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INTESTINE FLORA; IRRITABLE COLON; LACTULOSE BREATH TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMALL INTESTINE;

ABDOMINAL PAIN; ADOLESCENT; ANTI-BACTERIAL AGENTS; BREATH TESTS; CHILD; CHRONIC DISEASE; DOUBLE-BLIND METHOD; DYSPEPSIA; ENTERITIS; FEMALE; FERMENTATION; GASTROINTESTINAL AGENTS; HUMANS; IRRITABLE BOWEL SYNDROME; LACTULOSE; MALE; MIGRAINE DISORDERS; QUESTIONNAIRES; RIFAMYCINS; SEVERITY OF ILLNESS INDEX;

BACTERIA (MICROORGANISMS);

EID: 79953835382     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPG.0b013e3181effa3b     Document Type: Article

References (29)

1. Starfield B, Hoeklman RA, McCormick M, et al. Who provides health care to children and adolescents in the United States? Pediatrics 1984;74:991-7.
2. Hyams JS, Burke G, Davis PM, et al. Abdominal pain and irritable bowel syndrome in adolescents: a community based study. J Pediatr 1996;129:220-6. (Pubitemid 27483793)
3. Drossman DA, Li Z, Andruzzi E, et al. U.S. householder survey of functional gastrointestinal disorders: prevalence, sociodemography and health impact. Dig Dis Sci 1993;38:1569-80. (Pubitemid 23271409)
4. Apley J. The child with recurrent abdominal pain. Pediatr Clin North Am 1967;14:63-72.
5. Youssef NN, Murphy TG, Langseder AL, et al. Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions. Pediatrics 2006;117:54-9. (Pubitemid 46050519)
6. Hyman PE, Napolitano JA, Diego A, et al. Antroduodenal manometry in the evaluation of chronic functional gastrointestinal symptoms. Pediatrics 1990;86:39-44. (Pubitemid 20198456)
7. Van Ginkel R, Voskuijl WP, Benninga MA, et al. Alterations in rectal sensitivity and motility in childhood irritable bowel syndrome. Gastroenterology 2001;120:31-8. (Pubitemid 32061866)
8. Hyman PE, Bursch B, Sood M, et al. Visceral pain-associated disability syndrome: a descriptive analysis. J Pediatr Gastroenterol Nutr 2002;35:663-8. (Pubitemid 35417739)
9. Collins BS, Lin HC. Chronic abdominal pain in children is associated with high prevalence of abnormal microbial fermentation. Dig Dis Sci 2010;55:124-30.
10. Lin HC. Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome. JAMA 2004;292:852-8. (Pubitemid 39079672)
11. Levitt MD. Production and excretion of hydrogen gas in man. N Engl J Med 1969;281:122-7.
12. Strocchi A, Furne J, Ellis C, et al. Methanogens outcompete sulphate reducing bacteria for H2 in the human colon. Gut 1994;35:1098-101. (Pubitemid 24244266)
13. King CE, Toskes PP. Small intestine bacterial overgrowth. Gastroenterology 1979;76:1035-55. (Pubitemid 9250747)
14. Rhodes JM, Middleton P, Jewell DP. The lactulose hydrogen breath test as a diagnostic test for small-bowel bacterial overgrowth. Scand J Gastroenterol 1979;14:333-6. (Pubitemid 9185710)
15. Macfarlane GT, Gibson GR, Cummings JH. Comparison of fermentation reactions in different regions of the human colon. J Appl Bacteriol 1992;72:57-64.
16. Scarpellini E, Giorgio V, Gabrielli M, et al. Prevalence of small intestinal bacterial overgrowth in children with irritable bowel syndrome: a case-control study. J Pediatr 2009;155:416-20.
17. Pimentel M, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms in irritable bowel syndrome. Am J Gastroenterol 2000;95:3503-6.
18. Pimentel M, Chow EJ, Lin HC. Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome: a double blind, randomized controlled study. Am J Gastroenterol 2003;98:412-9. (Pubitemid 36232393)
19. Rasquin-Weber A, Hyman PE, Cucchiara S, et al. Childhood functional gastrointestinal disorders. Gut 1999;45(Suppl 2):II60-8.
20. Joseph F Jr, Rosenberg AJ. Breath hydrogen testing: diseased versus normal patients. J Pediatr Gastroenterol Nutr 1988;7:787-8.
21. Apley J, Naish N. Recurrent abdominal pain: a field survey of 1000 school children. Arch Dis Child 1958;33:165-70.
22. Chronic abdominal pain in children: a technical report of the American Academy of Pediatrics and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition. Pediatrics 2005;115:e370-81.
23. Pimentel M, Park S, Mirocha J, et al. The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann Intern Med 2006;145:557-63. (Pubitemid 46780934)
24. Lauritano EC, Gabrielli M, Lupascu A, et al. A. Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther 2005;22:31-5.
25. Scarpellini E, Gabrielli M, Lauritano CE, et al. A. High dosage rifaximin for the treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther 2007;25:781-6.
26. Riordan SM, McIver CJ, Walker BM, et al. The lactulose breath hydrogen test and small intestinal bacterial overgrowth. Am J Gastroenterol 1996;91:1795-803.
27. Corazza G, Strocchi A, Sorge M, et al. Prevalence and consistency of low breath H2 excretion following lactulose ingestion. Possible implications for the clinical use of the H2 breath test. Dig Dis Sci 1993;38:2010-6.
28. Mendoza E, Crismatt C, Matos R, et al. Diagnosis of small intestinal bacterial overgrowth in children: The use of lactulose in the breath hydrogen test as a screening test. Biomedica 2007;27:325-32. (Pubitemid 351890520)
29. Tillman R, King C, Toskes P. Continued experience with the xylose breath test: evidence that the small bowel culture as a gold standard for bacterial overgrowth may be tarnished. Gastroenterology 1981;80:1304.