Mechanical conditioning using magnetic nanoparticles bound to PDGF receptors on HBMSCs promotes the Smooth Muscle Alpha Actin (SMA) expression

IFMBE Proceedings

Volumn 30 IFMBE, Issue , 2011, Pages 23-25

  Hu, Bin ^a   Yang, Ying ^a   Dobson, J P ^a   El Haj, Alicia J ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

Magnetic conditioning; Mechanoresponsive; smooth muscle actin

Indexed keywords

CELL DIFFERENTIATION; CELL FATES; CELL MEMBRANE SURFACE; HUMAN BONE MARROW STROMAL CELLS; IMMUNOFLUORESCENCE STAINING; MAGNETIC CONDITIONING; MAGNETIC NANOPARTICLES; MAGNETIC STIMULATION; MECHANICAL CONDITIONING; MECHANICAL STIMULATION; MECHANORESPONSIVE; MECHANOTRANSDUCTION; MRNA EXPRESSION LEVEL; MULTIVALENT LIGANDS; PLATELET-DERIVED GROWTH FACTOR RECEPTORS; QUANTITATIVE RT-PCR; SMOOTH MUSCLES;

ANIMAL CELL CULTURE; CELL CULTURE; CELL MEMBRANES; MUSCLE; NANOPARTICLES; POLYPEPTIDES; PROTEINS; STEM CELLS;

NANOMAGNETICS;

EID: 79953817176     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-642-19044-5_7     Document Type: Conference Paper

References (5)

1. Vogel V, Sheetz MP (2009) Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways. Curr Opin Cell Biol 21:38-46.
2. Hughes S, McBain S, Dobson J, El Haj AJ (2008) Selective activation of mechanosensitive ion channels using magnetic particles. J R Soc Interface 5: 855-863. (Pubitemid 351882150)
3. Shimizu N, Yamamoto K, Obi S et al. (2008) Cyclic stain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGFR β. J Appl Physiol 104:766-772. (Pubitemid 351468806)
4. Lin YC, Grinnell F. (1993) Decreased level of PDGF-stimulated receptor autophosphorylation by fibroblasts in mechanically relaxed collagen matrices. J Cell Biology 122:663-672.
5. Ball SG, Shuttleworth CA, Kielty CM (2007) Platelet-derived growth factor receptor-α is a key determinant of smooth muscle α-actin filaments in bone marrow-derived mesenchymal stem cells. Int J Biochem Cell Biol 39: 379-391. (Pubitemid 44855658)