Changing microbiological profile of pathogenic bacteria in diabetic foot infections: Time for a rethink on which empirical therapy to choose?

Diabetologia

Volumn 54, Issue 1, 2011, Pages 58-64

  Ramakant, P ^a   Verma, A K ^a   Misra, R ^a   Prasad, K N ^a   Chand, G ^a   Mishra, A ^a   Agarwal, G ^a   Agarwal, A ^a   Mishra, S K ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Bacterial aetiology; Diabetic foot infections; Empirical therapy; Multidrug resistant organism

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; CEFTAZIDIME; CEFTRIAXONE; CIPROFLOXACIN; CLINDAMYCIN; CLOXACILLIN; GENTAMICIN; IMIPENEM; METRONIDAZOLE; PIPERACILLIN PLUS TAZOBACTAM; SULPERAZON;

ADULT; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL INFECTION; BACTERIUM CULTURE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC FOOT; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; INDIA; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; MEDICAL RECORD REVIEW; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTIDRUG RESISTANCE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; STAPHYLOCOCCUS AUREUS;

AGED; ANTI-BACTERIAL AGENTS; BACTERIA; DIABETIC FOOT; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; HUMANS; INDIA; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 79953801593     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1893-7     Document Type: Article

References (28)

1. Lipsky BA (2007) Emperical therapy for diabetic foot infections: are there clinical clues to guide antibiotic selection? Clin Microbiol Infect 13:351-353
2. Lipsky BA, Anthony R, Berendt H et al (2004) Diagnosis and treatment of diabetic foot infections. Clin Infect Dis 39:885-891
3. Nicolau DP, Stein GE (2010) Therapeutic options for diabetic foot infections: a review with an emphasis on tissue penetration characteristics. J Am Podiatr Med Assoc 100:52-63
4. Dang CN, Prasad YD, Boulton AJ, Jude EB (2003) Methicillin-resistant Staphylococcus aureus in the diabetic foot clinic: a worsening problem. Diabet Med 20:159-161 (Pubitemid 36269659)
5. Citron DM, Goldstein EJC, Merriam CV, Lipsky BA, Abramson MA (2007) Bacteriology of moderate to severe diabetic foot infections and in vitro activity of antimicrobial agents. J Clin Microbiol 45:2819-2828 (Pubitemid 47417321)
6. Lipsky BA, Pecoraro RE, Wheat LJ (1990) The diabetic foot: soft tissue and bone infection. Infect Dis Clin North Am 4:409-432
7. Grayson ML (1995) Diabetic foot infections: antimicrobial therapy. Infect Dis Clin North Am 9:143-161
8. Joseph WS, Axler DA (1990) Microbiology and antimicrobial therapy of diabetic foot infections. Clin Podiatr Med Surg 7:467-481 (Pubitemid 20277448)
9. Goldstein EJ, Citron DM, Nesbit CA (1996) Diabetic foot infections: bacteriology and activity of 10 oral antimicrobial agents against bacteria isolated from consecutive cases. Diab Care 19:638-641 (Pubitemid 26181113)
10. Sims D, Keating SE, DeVincentis AF (1984) Bacteriology of diabetic foot ulcers. J Foot Surg 23:149-151 (Pubitemid 14115789)
11. Jones EW, Edwards R, Finch R, Jeffcoate WJ (1985) A microbiological study of diabetic foot lesions. Diabet Med 2:213-215 (Pubitemid 15002155)
12. Nelson SB (2009) Management of diabetic foot infections in an era of increasing microbial resistance. Curr Infect Dis Rep 11:375-382
13. Smith RG (2003) Validation of Wagner's classification: a literature review. Ostomy Wound Manage 49:54-62
14. Oyibo SO, Jude EB, Tarawneh I, Nguyen HC, Harkless LB, Boulton AJ (2001) A comparison of two diabetic foot ulcer classification systems: the Wagner and the University of Texas wound classification systems. Diab Care 24:84-88 (Pubitemid 32104225)
15. Clinical and Laboratory Standards Institute (2007) M100-S17. Performance standards for antimicrobial susceptibility testing. 16th informational supplement. Clinical and Laboratory Standards Institute, Wayne
16. Gadepalli R, Dhawan B, Sreenivas V, Kapil A, Ammini AC, Chaudhry R (2006) A clinico-microbiological study of diabetic foot ulcers in an Indian tertiary care hospital. Diab Care 29:1727-1732 (Pubitemid 44156621)
17. Shankar EM, Mohan V, Premlatha G, Srinivasan RS, Usha AR (2006) Bacterial etiology of diabetic foot infections in South India. Eur J Intern Med 16:567-570
18. Raja NS (2007) Microbiology of diabetic foot infections in a teaching hospital in Malaysia: a retrospective study of 194 cases. J Microbiol Immunol Infect 40:39-44
19. Prasad KN, Prasad N, Gupta A, Sharma RK, Verma AK, Ayyagari A (2004) Fungal peritonitis in patients on continous ambulatory peritoneal dialysis: a single centre Indian experience. J Infect 48:96-101 (Pubitemid 38072208)
20. Bansal E, Garg A, Bhatia S, Attri AK, Chander J (2008) Spectrum of microbial flora in diabetic foot ulcers. Indian J Pathol Microbiol 51:123-126
21. Kumar MS, Lakshmi V, Rajagopalan R (2006) Occurrence of extended spectrum beta lactamases among Enterobacteriaceae spp. isolated at a tertiary care institute. Indian J Med Microbiol 24:208-211 (Pubitemid 44315655)
22. Mohanty S, Kapil A, Dhawan B, Das BK (2004) Bacteriological and antimicrobial susceptibility profile of soft tissue infections from Northern India. Indian J Med Sci 58:10-15 (Pubitemid 41646737)
23. Patel V, Vaidya R, Naik D, Borker P (2005) Irrational drug use in India: a prescription survey from Goa. J Postgrad Med 51:9-12 (Pubitemid 40976021)
24. Sharma R, Sharma CL, Kapoor B (2005) Antibacterial resistance: current problems and possible solutions. Indian J Med Sci 59:120-129 (Pubitemid 40545123)
25. Dallenne C, Costa AD, Decre D, Favier C, Guillaume A (2010) Development of a set of multiplex PCR assays for the detection of genes encoding important β-lactamases in Enterobacteriaceae. J Antimicrob Chemother 65:490-495
26. Senneville E, Melliez H, Beltrand E, Legout E, Valette M, Cazaubiel M (2006) Culture of percutaneous bone biopsy specimens for diagnosis of diabetic foot osteomyelitis: concordance with ulcer swab cultures. Clin Infect Dis 42:57-62 (Pubitemid 41832080)
27. Pellizzer G, Strazzabosco M, Presi S et al (2001) Deep tissue biopsy vs superficial swab culture monitoring in the microbiological assessment of limb-threatening diabetic foot infection. Diabet Med 18:822-827 (Pubitemid 32953789)
28. Slater RA, Lazarovitch T, Boldur I et al (2004) Swab cultures accurately identify bacterial pathogens in diabetic foot wounds not involving bone. Diabet Med 21:705-709 (Pubitemid 38916214)