Ocular surface injuries in autoimmune dry eye. The severity of microscopical disturbances goes parallel with the severity of symptoms of dryness

Histology and Histopathology

Volumn 24, Issue 10, 2009, Pages 1357-1365

  Cejkova J ^a   Ardan, T ^a   Cejka C ^a,b   Malec, J ^b   Jirsova K ^c   Filipec, M ^c   Ruz Ickova E ^c   Dotielova D ^b   Brunova B ^b  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^b UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^c Charles University in Prague and General University Hospital in Prague   (Czech Republic)

Author keywords

Antioxidant enzymes; Autoimmune dry eye; Oxidative injuries; Pro inflammatory cytokines; Reactive oxygen and nitrogen species

Indexed keywords

OXIDIZING AGENT;

EPITHELIUM; EYE; HUMAN; KERATOCONJUNCTIVITIS SICCA; LACRIMAL APPARATUS; LACRIMAL FLUID; METABOLISM; OXIDATION REDUCTION REACTION; REVIEW; SJOEGREN SYNDROME; XEROPHTHALMIA;

EPITHELIUM; EYE; HUMANS; KERATOCONJUNCTIVITIS SICCA; LACRIMAL APPARATUS; OXIDANTS; OXIDATION-REDUCTION; SJOGREN'S SYNDROME; TEARS; XEROPHTHALMIA;

EID: 79953798064     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Abdulnour R.E., Peng X., Finigan J.H., Han E.J., Hasan E.J., Birukov K.G., Reddy S.P., Watkins J.E. 3rd, Kayyali U.S., Garcia J.G., Tuder R.M. and Hassoun P.M. (2006). Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathway. Am. J. Physiol. Lung Cell Mol. Physiol. 291, L345-353.
2. Augustin A.J., Spitznas M., Kaviani N., Meller D., Koch F.H., Grus F. and Göbbels M.J. (1995). Oxidative reactions in the tear fluid of patients suffering from dry eyes. Graefes Arch. Clin. Exp. Ophthalmol. 233, 694-698.
3. Alvarez S.F. (2008). Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren ́s syndrome. Matrix Biol. 27, 53-66.
4. Beauregard C., Brandt P.C. and Chiou G.C.Y. (2003). Induction of nitric oxide synthase and over-production of nitric oxide by interleukin-1ß in cultured lacrimal gland acinar cells. Exp. Eye Res. 77, 109-114.
5. Bredt D.S. and Snyder S.H. (1994). Nitric oxide, a physiologic messenger molecule. Annu. Rev. Biochem. 63, 175-195.
6. Cejková J., Ardan T., Jirsová K., Jechová G., Malec J., Šimonová Z., Cejka C., Filipec M., Dotrelová D. and Brunová B. (2007a). The role of conjunctival epithelial cell xanthine oxidoreductase/xanthine oxidase in oxidative reactions on the ocular surface of dry eye patients with SjögrenÕs syndrome. Histol. Histopathol. 22, 997-1003.
7. Cejková J., Ardan T., Šimonová Z., Cejka C., Malec J., Jirsová K., Filipec M., Dotrelová D. and Brunová B. (2007b). Nitric oxide synthase induction and cytotoxic nitrogen-related oxidant formation in conjunctival epithelium of dry eye (SjögrenÕs syndrome). Nitric Oxide 17, 10-17.
8. Cejková J., Ardan T., Šimonová Z., Cejka C., Malec J., Dotrelová D. and Brunová B. (2008). Decreased expression of antioxidant enzymes in the conjunctival epithelium of dry eye (SjögrenÕs syndrome) and its possible contribution to the development of ocular surface oxidative injuries. Histol. Histopathol. 23, 1477-1483.
9. Connolly M.K. (2001). Sjögren's syndrome. Semin. Cutan. Med. Surg. 20, 46-52.
10. Fox R.I. (2005). Sjögren's syndrome. Lancet 366, 321-331.
11. Harris C.M. and Massey V. (1997). The reaction of reduced xanthine dehydrogenase with molecular oxygen. Reaction kinetics and measurement of superoxide radical. J. Biol. Chem. 172, 8370-8379.
12. Kelley E.E., Hock T., Khoo N.K., Richardson G.R., Johnson K.K., Powell P.C., Giles G.I., Agarwal A., Lancaster J.R. Jr. and Tarpey M.M. (2006). Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells. Free Radic. Biol. Med. 40, 952-959.
13. Komaki Y., Sugiura H., Koarai A., Tomaki M., Ogawa H., Akita T., Hattori T. and Ichinose M. (2005). Cytokine-mediated xanthine oxidase upregulation in chronic obstructive pulmonary disease ́s airways. Pulm. Pharmacol. Ther. 18, 297-302.
14. Luo L., Li D.Q., Doshi A., Farley W., Corrales R.M. and Pflugfelder S.C. (2004). Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest. Ophthalmol. Vis. Sci. 45, 4293-4301.
15. Manthorpe P., Oxholm J.U., Prause M. and Schiodt K. (1986). The Copenhagen criteria for Sjögren ́s syndrome. Scand. J. Rheumatol. Suppl. 61, 19-21.
16. Murube J., Nemeth J., Hoh H., Kaynak-Hekimhan P., Horwath-Winter J., Agarwal A., Baudouin C., Bemitez del Castillo J.M., Cervenka S., ChenZhuo L., Ducasse A., Duran J., Holly F., Javate R., Nepp J., Paulsen F., Rahimi A., Raus P., Shalaby O., Sieg P., Soriano H., Spinelli D., Ugurbas S.H. and Van Setten, G. (2005). The triple classification of dry eye for practical use. Eur. J. Ophthalmol. 15, 660-667.
17. Page S., Powell D., Benboubetra M., Stevens C.R., Blake D.R., Selase F., Wolstenholme A.J. and Harrison R. (1998). Xanthine oxidoreductase in human mammary epithelial cells: activation in response to inflammatory cytokines. Biochim. Biophys. Acta 1381, 191-202.
18. Patel S.J. and Lundy D.C. (2002). Ocular manifestations of autoimmune disease. Am. Fam. Physician 66, 991-998.
19. Parks D.A., Skinner K.A., Tan S. and Skinner H.B. (1999). Xanthine oxidase in biology and medicine. In: Reactive oxygen species in biological systems. Colton G. (ed). Kluwer Academic/Plenum. New York. pp 397-420.
20. Pflugfelder S.C., Jones D., Ji Z., Afonso A.D. and Monroy D. (1999). Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca. Curr. Eye Res. 19, 201-211.
21. Pflugfelder S.C. (2004). Antiinflammatory therapy for dry eye. Am. J. Ophthalmol. 137, 337-342.
22. Robinson C.P., Cornelius J., Bounous D.I., Yamamoto H., Humpreys-Beher M.G. and Peck A.B. (1998). Infiltrating lymphocyte populations and cytokine production in the salivary and lacrimal glands of autoimmune NOD mice. Adv. Exp. Med. Biol. 438, 493-497.
23. Rosenbaum J.T., Brito B., Han Y.B., Park J. and Planck S.R. (1998). Cytokines. An overview. Adv. Exp. Med. Biol. 438, 441-446.
24. Solaroglu I., Okutan O., Kaptanoglu E., Beskonakli E. and Kilinc K. (2005). Increased xanthine oxidase activity after traumatic brain injury in rats. J. Clin. Neurosci. 12, 273-275.
25. Solomon A., Dursun D., Liu Z., Xie Y., Macri A. and Pflugfelder S.C. (2001). Pro- and antiinflammatory forms of interleukin -1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest. Ophthalmol. Vis. Sci. 42, 2283-2292.
26. Srinivasan S. and Slomovic A.R. (2007). Sjögren's syndrome. Compr. Ophthalmol. Update 8, 205-212.
27. Tabbara K.F. and Vera-Cristo C.L. (2000). Sjögren's syndrome. Curr. Opin. Ophthalmol. 11, 449-454
28. van Bijsterveld O.P. (1969). Diagnostic test in the sicca syndrome. Arch. Ophthalmol. 82, 10-14.
29. Yoshida M., Yoshimura N., Hangai M., Tanigara H. and Honda Y. (1994). Interleukin 1alpha, interleukin-1beta and tumor necrosis factor gene expression in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 35, 1107-1113.
30. Wu G.S., Zhang J. and Rao N.A. (1997). Peroxynitrite and oxidative damage in experimental autoimmune uveitis. Invest. Ophthalmol. Vis. Sci. 38, 1333-1339.