Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-B activity and miR-16-1

Acta Pharmacologica Sinica

Volumn 32, Issue 4, 2011, Pages 503-511

  Meng, Hai Tao ^a   Zhu, Li ^a   Ni, Wan Mao ^a   You, Liang Shun ^a   Jin, Jie ^a   Qian, Wen Bin ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG SCI TECH UNIVERSITY   (China)

Author keywords

bortezomib; miR 16 1*; NF B; T cell lymphocytic leukemia; triptolide

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4',6 DIAMIDINO 2 PHENYLINDOLE; BORTEZOMIB; CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; MICRORNA; TRIPTOLIDE;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DISEASE ASSOCIATION; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE TRANSLOCATION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LEUKEMIA CELL LINE; MICROARRAY ANALYSIS; PROTEIN EXPRESSION; RAJI CELL; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; STAINING; T CELL LEUKEMIA; WESTERN BLOTTING;

CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES; DOWN-REGULATION; EPOXY COMPOUNDS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICRORNAS; NF-KAPPA B; PHENANTHRENES;

EID: 79953791136     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.237     Document Type: Article

References (54)

1. Chen BJ. Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphoma 2001; 42: 253-65. (Pubitemid 32725582)
2. Tao XL, Sun Y, Dong Y, Xiao YL, Hu DW, Shi YP, et al. A prospective, controlled, double-blind, cross-over study of Tripterygium wilfodii hook F in treatment of rheumatoid arthritis. Chin Med J (Engl) 1989; 102: 327-32. (Pubitemid 19197370)
3. Shamon LA, Pezzuto JM, Graves JM, Mehta RR, Wangcharoentrakul S, Sangsuwan R, et al. Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii. Cancer Lett 1997; 112: 113-7. (Pubitemid 27067433)
4. Carter BZ, Mak DH, Schober WD, McQueen T, Harris D, Estrov Z, et al. Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood 2006; 108: 630-7. (Pubitemid 44061364)
5. Lou YJ, Jin J. Triptolide down-regulates bcr-abl expression and induces apoptosis in chronic myelogenous leukemia cells. Leuk Lymphoma 2004; 45: 373-6. (Pubitemid 38181443)
6. Shi X, Jin Y, Cheng C, Zhang H, Zou W, Zheng Q, et al. Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation. Clin Cancer Res 2009; 15: 1686-97.
7. Yinjun L, Jie J, Yungui W. Triptolide inhibits transcription factor NFkappaB and induces apoptosis of multiple myeloma cells. Leuk Res 2005; 29: 99-105. (Pubitemid 39487915)
8. Lu LH, Lian YY, He GY, Lin SP, Huan SH, Chen ZZ, et al. Clinical study of triptolide in treatment of acute leukemia. Clin Exp Investig Hematol 1992; 3: 1-3.
9. Kiviharju TM, Lecane PS, Sellers RG, Peehl DM. Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin Cancer Res 2002; 8: 2666-74. (Pubitemid 34856355)
10. Harousseau JL, Dombret H, Pigneux A, Michallet M, Brandely M. Phase I study of F60008, a triptolide derivative, in patients with refractory or relapsing acute leukemias. Haematologica 2008; 93(s1): 14 abs. 0038.
11. Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002; 3: 221-7.
12. Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 2009; 8: 33-40.
13. Lounnas N, Frelin C, Gonthier N, Colosetti P, Sirvent A, Cassuto JP, et al. NF-kappaB inhibition triggers death of imatinib-sensitive and imatinib-resistant chronic myeloid leukemia cells including T315I Bcr- Abl mutants. Int J Cancer 2009; 125: 308-17.
14. Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, Hassane DC, et al. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood 2007; 110: 4427-35. (Pubitemid 351377809)
15. Staudt LM. The molecular and cellular origins of Hodgkin's disease. J Exp Med 2000; 191: 207-12. (Pubitemid 30060911)
16. Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, et al. Lymphoma/Leukemia Molecular Profiling Project. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002; 346: 1937-47. (Pubitemid 34651353)
17. Kordes U, Krappmann D, Heissmeyer V, Ludwig WD, Scheidereit C. Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells. Leukemia 2000; 14: 399-402. (Pubitemid 30142862)
18. Zhao WL. Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways. Leukemia 2010; 24: 13-21.
19. Cardoso BA, Gírio A, Henriques C, Martins LR, Santos C, Silva A, et al. Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications. Braz J Med Biol Res 2008; 41: 344-50.
20. Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 2001; 98: 2301-7.
21. dos Santos NR, Williame M, Gachet S, Cormier F, Janin A, Weih D, et al. RelB-dependent stromal cells promote T-cell leukemogenesis. PLoS ONE 2008; 3: e2555.
22. Tracey L, Streck CJ, Du Z, Williams RF, Pfeffer LM, Nathwani AC, et al. NF-kappaB activation mediates resistance to IFN beta in MLL-rearranged acute lymphoblastic leukemia. Leukemia 2010; 24: 806-12.
23. Ambros V. The evolution of our thinking about microRNAs. Nat Med 2008; 14: 1036-40.
24. Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA. MicroRNAs-the micro steering wheel of tumour metastases. Nat Rev Cancer 2009; 9: 293-302.
25. Leung AK, Sharp PA. MicroRNAs: a safeguard against turmoil? Cell 2007; 130: 581-5.
26. Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, et al. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci U S A 2007; 104: 19971-6.
27. Gaur A, Jewell DA, Liang Y, Ridzon D, Moore JH, Chen C, et al. Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res 2007; 67: 2456-68. (Pubitemid 46548930)
28. Cho WC. MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy. Int J Biochem Cell Biol 2010; 42: 1273-81.
29. Cho WC. MicroRNAs in cancer-form research to therapy. Biochim Biophys Acta 2010; 1805: 209-17.
30. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002; 99: 15524-9. (Pubitemid 35403967)
31. Climent J, Dimitrow P, Fridlyand J, Palacios J, Siebert R, Albertson DG, et al. Deletion of chromosome 11q predicts response to anthracycline- based chemotherapy in early breast cancer. Cancer Res 2007; 67: 818-26. (Pubitemid 46192223)
32. Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak VP, Chekhun VF, et al. Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther 2008; 7: 2152-9.
33. Yang H, Kong W, He L, Zhao JJ, O'Donnell JD, Wang J, et al. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res 2008; 68: 425-33. (Pubitemid 351380068)
34. Qian W, Liu J, Tong Y, Yan S, Yang C, Yang M, et al. Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis. Leukemia 2008; 22: 361-9. (Pubitemid 351250541)
35. Yang C, Tong Y, Ni W, Liu J, Xu W, Li L, et al. Inhibition of autophagy induced by overexpression of MDA/Interleukin-24 using a PI3K inhibitor results in significant enhanced antileukmia activity in vivo. Cancer Gene Ther 2010; 17: 109-19.
36. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 1998; 95: 14863-8. (Pubitemid 29003722)
37. Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, et al. Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood 2009; 113: 2003-13.
38. Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, et al. MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci U S A 2008; 105: 5166-71. (Pubitemid 351738528)
39. Liu X, Jiang L, Wang A, Yu J, Shi F, Zhou X. MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines. Cancer Lett 2009; 286: 217-22.
40. Santarpia L, Nicoloso M, Calin GA. MicroRNAs: a complex regulatory network drives the acquisition of malignant cell phenotype. Endocr Relat Cancer 2010; 17: F51-75.
41. Mori N, Fujii M, Ikeda S, Yamada Y, Tomonaga M, Ballard DW, et al. Constitutive activation of NF-κB in primary adult T-cell leukemia cells. Blood 1999; 93: 2360-8. (Pubitemid 29153640)
42. Satou Y, Nosaka K, Koya Y, Yasunaga JI, Toyokuni S, Matsuoka M. Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro. Leukemia 2004; 18: 1357-63. (Pubitemid 39136745)
43. Mori N, Yamada Y, Ikeda S, Yamasaki Y, Tsukasaki K, Tanaka Y, et al. Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 2002; 100: 1828-34. (Pubitemid 34925163)
44. Qiu D, Zhao G, Aoki Y, Shi L, Uyei A, Nazarian S, et al. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional activation. J Biol Chem 1999; 274: 13443-50.
45. Carter BZ, Mak DH, Schober WD, Dietrich MF, Pinilla C, Vassilev LT, et al. Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. Blood 2008; 111: 3742-50.
46. Choi YJ, Kim TG, Kim YH, Lee SH, Kwon YK, Suh SI, et al. Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells. Biochem Pharmacol 2003; 66: 273-80. (Pubitemid 36776400)
47. Westerheide SD, Kawahara TL, Orton K, Morimoto RI. Triptolide, an inhibitor of the human heat shock response that enhances stressinduced cell death. J Biol Chem 2006; 281: 9616-22. (Pubitemid 43864680)
48. Phillips PA, Dudeja V, McCarroll JA, Borja-Cacho D, Dawra RK, Grizzle WE, et al. Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70. Cancer Res 2007; 67: 9407-16. (Pubitemid 47535931)
49. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, et al. MiR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 2005; 102: 13944-9. (Pubitemid 41377683)
50. Wang F, Fu XD, Zhou Y, Zhang Y. Down-regulation of the cyclin E1 oncogene expression by microRNA-16-1 induces cell cycle arrest in human cancer cells. BMB Rep 2009; 42: 725-30.
51. Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J, et al. MiR-16 family induces cell cycle arrest by regulating multiple cell cycle genes. Nucleic Acids Res 2008; 36: 5391-404.
52. Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005; 353: 1793-801. (Pubitemid 41549891)
53. Calin GA, Liu CG, Sevignani C, Ferracin M, Felli N, Dumitru CD, et al. MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci U S A 2004; 101: 11755-60. (Pubitemid 39095368)
54. Caligaris-Cappio F, Hamblin TJ. B-cell chronic lymphocytic leukemia: a bird of a different feather. J Clin Oncol 1999; 17: 399-408. (Pubitemid 29022419)