3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase

Journal of Medicinal Chemistry

Volumn 54, Issue 7, 2011, Pages 2282-2292

  Tang, Jing ^a   Maddali, Kasthuraiah ^b   Metifiot, Mathieu ^b   Sham, Yuk Y ^a   Vince, Robert ^a   Pommier, Yves ^b   Wang, Zhengqiang ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYPYRIMIDINE 2,4 DIONE DERIVATIVE; INTEGRASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG SCREENING; ENZYME INHIBITION; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG RESISTANCE, VIRAL; HIV; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953784039     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1014378     Document Type: Article

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