Simultaneous use of mifepristone and misoprostol for early pregnancy termination

Taiwanese Journal of Obstetrics and Gynecology

Volumn 50, Issue 1, 2011, Pages 11-14

  Li, Yiu Tai ^a   Hsieh, James Ching Hung ^a,b   Hou, Guang Qiong ^a   Chen, Tien Hui ^c   Chu, Yi Chih ^a   Lin, Ta Chin ^a   Kuan, Long Ching ^a   Lin, Mau ^a   Tang, Hsun Han ^a,d   Kuo, Tsung Cheng ^a  

^a KUO GENERAL HOSPITAL   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c CHANG BING SHOW CHWAN MEMORIAL HOSPITAL   (Taiwan)

^d SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Concurrent medical abortion; Mifepristone; Misoprostol

Indexed keywords

ERGOMETRINE; MIFEPRISTONE; MISOPROSTOL; PARACETAMOL;

ABDOMINAL PAIN; ADULT; ARTICLE; DIARRHEA; DIZZINESS; DRUG EFFICACY; DRUG TOLERABILITY; ENDOMETRITIS; FEMALE; FEVER; FIRST TRIMESTER PREGNANCY; FOLLOW UP; GESTATIONAL AGE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MEDICAL ABORTION; NAUSEA; PATIENT SATISFACTION; PELVIC INFLAMMATORY DISEASE; PELVIS PAIN SYNDROME; PREGNANCY TERMINATION; SHIVERING; TRANSVAGINAL ECHOGRAPHY; TREATMENT OUTCOME; UNWANTED PREGNANCY; VAGINA BLEEDING; VOMITING;

ABORTIFACIENT AGENTS, NONSTEROIDAL; ABORTIFACIENT AGENTS, STEROIDAL; ABORTION, INDUCED; ADMINISTRATION, INTRAVAGINAL; ADMINISTRATION, ORAL; ADULT; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MIDDLE AGED; MIFEPRISTONE; MISOPROSTOL; PATIENT SATISFACTION; PREGNANCY; PREGNANCY TRIMESTER, FIRST; TREATMENT OUTCOME;

EID: 79953780795     PISSN: 10284559     EISSN: 10284559     Source Type: Journal    
DOI: 10.1016/j.tjog.2010.09.002     Document Type: Article

References (16)

1. El-Refaey H., Rajasekar D., Abdalla M., Calder L., Templeton A. Induction of abortion with mifepristone (RU486) and oral or vaginal misoprostol. N Eng J Med 1995, 332:983-987.
2. Peyron R., Aubeny E., Targosz V. Early termination of pregnancy with mifepristone (RU486) and the orally active prostaglandin misoprostol. N Engl J Med 1993, 328:1509-1513.
3. Kahn J.G., Beaker B.J., Maclsaa L. The efficacy of medical abortion: a meta-analysis. Contraception 2000, 61:29-40.
4. Lin H.W., Chien T.Y., Jeng C.J., Chen S.C., Chen H.F., Hwang J.L. Comparison of two doses of mifepristone in combination with misoprostol for early pregnancy termination. Taiwanese J Obstet Gynecol 2002, 41:155-161.
5. Mckinley C., Thong K.J., Baird D.T. The effect of dose of mifepristone and gestation on the efficacy of medical abortion with mifepristone and misoprostol. Hum Reprod 1993, 8:1502-1505.
6. Marions L. Mifepristone dose in the regimen with misoprostol for medical abortion. Contraception 2006, 74:21-25.
7. Zieman M., Fong S.K., Benowitz N.L., Banskter D., Darney P.D. Absorption kinetics of misoprostol with oral or vaginal administration. Obstet Gynecol 1997, 90:88-92.
8. Fiala C., Gemzell-Danielsson K. Review of medical abortion using mifepristone in combination with prostaglandin analogue. Contraception 2006, 74:66-86.
9. Li Y.T., Chen F.M., Chen T.H., Li S.C., Chen M.L., Kuo T.C. Concurrent use of mifepristone and misoprostol for early medical abortion. Taiwan J Obstet Gynecol 2006, 45:325-328.
10. Elul B., Ellertson C., Winikoff B. Side effects of mifepristone-misoprostol abortion versus surgical abortion: data from a trial in China, Cuba, and India. Contraception 1999, 59:107-114.
11. Murthy A.S., Creinin M.D., Harwood B., Schreiber C. A pilot study of mifepristone and misoprostol administered at the same time for abortion up to 49 days gestation. Contraception 2005, 71:333-336.
12. Schreiber C.A., Creinin M.D., Harwood B., Murthy A.S. A pilot study of mifepristone and misoprostol administered at the same time for abortion in women with gestation from 50 to 63 days. Contraception 2005, 71:447-450.
13. Creinin M.D., Schreiber C.A., Bednarek P., Lintu H., Wagner M.S., Meyn L.A. Mifepristone and misoprostol administered simultaneously versus 24 hours apart for abortion. A randomized controlled trial. Obstet Gynecol 2007, 109:885-894.
14. von Hertzen H., Piaggio G., Wojdyla D. Two mifepristone doses and two intervals of misoprostol administration for termination of early pregnancy: a randomized factorial controlled equivalence trials. BJOG 2009, 116:381-389.
15. Lohr P.A., Reeves M.F., Hayes J.L. Oral mifepristone and buccal misoprostol administered simultaneously for abortion: a pilot study. Contraception 2007, 76:215-220.
16. American College of Obstetricians and Gynecologists Committee on Practice Bulletins-Gynecology ACOG practice bulletin. Clinical management guidelines for obstetrician-gynecologists. Medical management of abortion. Obstet Gynecol 2001, 97:1-13.