Visualization of human retinal micro-capillaries with phase contrast high-speed optical coherence tomography

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7889, Issue , 2011, Pages

  Kim, Dae Yu ^a,b   Fingler, Jeff ^c   Werner, John S ^a,b   Schwartz, Daniel M ^d   Fraser, Scott E ^c   Zawadzki, Robert J ^b  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c California Institute of Technology   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Imaging system; Medical optics instrumentation; Optical coherence tomography; Phase contrast technique

Indexed keywords

BLOOD FLOW; FLUORESCEIN ANGIOGRAPHY; FOURIER-DOMAIN OPTICAL COHERENCE TOMOGRAPHY; HIGH SENSITIVITY; HIGH-SPEED; HIGH-SPEED ACQUISITION RATES; HIGH-SPEED OPTICAL COHERENCE TOMOGRAPHY; IN-VIVO; IN-VIVO IMAGING; MEDICAL OPTICS INSTRUMENTATION; MICRO-CAPILLARIES; MICRO-VASCULATURE; MOTION ARTIFACT; NON-INVASIVE; OPTICAL COHERENCE TOMOGRAPHY; OPTIMAL PARAMETER; PHASE CONTRAST TECHNIQUE; PHASE CONTRASTS; PHASE VARIANCE; SAMPLING DENSITIES; SCANNING AREA; VOLUMETRIC VISUALIZATION;

IMAGING SYSTEMS; INSTRUMENTS; MEDICAL IMAGING; MICROCIRCULATION; OPHTHALMOLOGY; SCANNING; TOMOGRAPHY; VISUALIZATION;

COHERENT LIGHT;

EID: 79953757865     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.873896     Document Type: Conference Paper

References (16)

1. F. Musa, W. J. Muen, R. Hancock, and D. Clark, "Adverse effects of fluorescein angiography in hypertensive and elderly patients," Acta Ophthalmol. Scand, 84: 740-742 (2006)
2. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181 (1991)
3. A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann "In vivo optical coherence tomography," Am. J. Ophthalmol. 116, 113-114 (1993)
4. J. Fingler, D. Schwartz, C. Yang, and S. E. Fraser, "Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography," Opt. Express 15(20), 12636-12653 (2007)
5. J. Fingler, C. Readhead, D. M. Schwartz, and S. E. Fraser, "Phase-contrast OCT imaging of transverse flows in the mouse retina and choroid," Invest. Ophthalmol. Vis. Sci. 49(11), 5055-5059 (2008)
6. J. Fingler, R. J. Zawadzki, J. S. Werner, D. Schwartz, and S. E. Fraser, "Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique," Opt. Express 17, 22190-22200 (2009)
7. L. An, H. M. Subhush, D. J. Wilson, and R. K. Wang, "High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography, " J. Biomed. Opt., Vol. 15, 026011 (2010)
8. L. Yu and, Z. Chen, " Doppler variance imaging for three-dimensional retina and choroid angiography, " J. Biomed. Opt., Vol. 15, 016029 (2010)
9. T. Schmoll, C. Kolbitsch, and R. A. Leitgeb, "Ultra-high-speed volumetric tomography of human retinal blood flow," Opt. Express 17, 4166-4176 (2009)
10. Y. Tao, K. Kennedy, and J. Izatt, "Velocity-resolved 3D retinal microvessel imaging using single-pass flow imaging spectral domain optical coherence tomography," Opt. Express 17(5), 4177-4188 (2009)
11. A. Szkulmowska, M. Szkulmowski, D. Szlag, A. Kowalczyk, and M. Wojtkowski, "Three-dimensional quantitative imaging of retinal and choroidal blood flow velocity using joint Spectral and Time domain Optical Coherence Tomography," Opt. Express 17(13), 10584-10598 (2009)
12. S. Makita, T. Fabritius, and Y. Yasuno, "Quantitative retinal-blood flow measurement with three-dimensional vessel geometry determination using ultrahigh-resolution Doppler optical coherence angiography," Opt. Lett. 33, 836-838 (2008)
13. D. Kim, J.S. Werner, R.J. Zawadzki, "Comparison of phase-shifting techniques for in vivo full-range, high-speed Fourier-domain optical coherence tomography," Journal of Biomedical Optics, 15 (5), 056011-056011-8 (2010).
14. N. Nassif, B. Cense, B. Park, M. Pierce, S. Yun, B. Bouma, G. Tearney, T. Chen, and J. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12, 367-376 (2004).
15. R. Zawadzki, S. Jones, S. Olivier, M. Zhao, B. Bower, J. Izatt, S. Choi, S. Laut, and J. Werner, "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging," Opt. Express 13, 8532-8546 (2005).
16. M. Wojtkowski, V. Srinivasan, T. Ko, J. Fujimoto, A. Kowalczyk, and J. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).