Apolipoprotein B/A1 ratio is associated with free androgen index and visceral adiposity and may be an indicator of metabolic syndrome in male children and adolescents

Clinical Endocrinology

Volumn 74, Issue 5, 2011, Pages 579-586

  Lee, Yong Ho ^a   Choi, Sung Hee ^b,c   Lee, Kwan Woo ^d   Kim, Dae Jung ^d  

^a Yonsei University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University Bundang Hospital   (South Korea)

^d Ajou University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ANDROGEN; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ABDOMINAL FAT; ADOLESCENT; ANTHROPOMETRIC PARAMETERS; APOLIPOPROTEIN B APOLIPOPROTEIN A1 RATIO; ARTICLE; BODY HEIGHT; BODY MASS; CHILD; CHOLESTEROL BLOOD LEVEL; CORRELATION ANALYSIS; FREE ANDROGEN INDEX; HORMONE BLOOD LEVEL; HUMAN; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; METABOLIC SYNDROME X; OBESITY; PRIORITY JOURNAL; SCHOOL CHILD; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADOLESCENT; ANDROGENS; ANTHROPOMETRY; APOLIPOPROTEIN A-I; APOLIPOPROTEINS B; BIOLOGICAL MARKERS; BODY COMPOSITION; CHILD; HUMANS; INTRA-ABDOMINAL FAT; MALE; METABOLIC SYNDROME X;

EID: 79953741984     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2010.03953.x     Document Type: Article

References (38)

1. Walldius, G., &, Jungner, I., (2006) The apoB/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy-a review of the evidence. Journal of Internal Medicine, 259, 493-519.
2. Hamilton, C.A., (1997) Low-density lipoprotein and oxidised low-density lipoprotein: their role in the development of atherosclerosis. Pharmacology and Therapeutics, 74, 55-72. (Pubitemid 27337354)
3. Barter, P.J., &, Rye, K.A., (2006) The rationale for using apoA-I as a clinical marker of cardiovascular risk. Journal of Internal Medicine, 259, 447-454.
4. Sierra-Johnson, J., Somers, V.K., Kuniyoshi, F.H., et al. (2006) Comparison of apolipoprotein-B/apolipoprotein-AI in subjects with versus without the metabolic syndrome. The American Journal of Cardiology, 98, 1369-1373. (Pubitemid 44666643)
5. Walldius, G., Jungner, I., Aastveit, A.H., et al. (2004) The apoB/apoA-I ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary risk. Clinical Chemistry and Laboratory Medicine, 42, 1355-1363. (Pubitemid 40057822)
6. Meisinger, C., Loewel, H., Mraz, W., et al. (2005) Prognostic value of apolipoprotein B and A-I in the prediction of myocardial infarction in middle-aged men and women: results from the MONICA/KORA Augsburg cohort study. European Heart Journal, 26, 271-278. (Pubitemid 40222365)
7. Hedley, A.A., Ogden, C.L., Johnson, C.L., et al. (2004) Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. Journal of the American Medical Association, 291, 2847-2850. (Pubitemid 38747805)
8. Becque, M.D., Katch, V.L., Rocchini, A.P., et al. (1988) Coronary risk incidence of obese adolescents: reduction by exercise plus diet intervention. Pediatrics, 81, 605-612.
9. Weiss, R., &, Caprio, S., (2005) The metabolic consequences of childhood obesity. Best Practice and Research. Clinical Endocrinology and Metabolism, 19, 405-419. (Pubitemid 41263795)
10. Choi, Y.J., Jo, Y.E., Kim, Y.K., et al. (2006) High plasma concentration of remnant lipoprotein cholesterol in obese children and adolescents. Diabetes Care, 29, 2305-2310.
11. Sellers, E.A., Singh, G.R., &, Sayers, S.M., (2009) Apo-B/AI ratio identifies cardiovascular risk in childhood: the Australian Aboriginal Birth Cohort study. Diabetes and Vascular Disease Research, 6, 94-99.
12. Morrison, J.A., Barton, B.A., Biro, F.M., et al. (2003) Sex hormones and the changes in adolescent male lipids: longitudinal studies in a biracial cohort. The Journal of Pediatrics, 142, 637-642. (Pubitemid 36737166)
13. Matthews, D.R., Hosker, J.P., Rudenski, A.S., et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412-419. (Pubitemid 15018832)
14. Cunningham, S.K., Loughlin, T., Culliton, M., et al. (1985) The relationship between sex steroids and sex-hormone-binding globulin in plasma in physiological and pathological conditions. Annals of Clinical Biochemistry, 22 (Pt 5), 489-497. (Pubitemid 16241850)
15. Cole, T.J., Bellizzi, M.C., Flegal, K.M., et al. (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. British Medical Journal, 320, 1240-1243. (Pubitemid 30240471)
16. Kanazawa, M., Yoshiike, N., Osaka, T., et al. (2002) Criteria and classification of obesity in Japan and Asia-Oceania. Asia Pacific Journal of Clinical Nutrition, 11 (Suppl. 8), S732-S737.
17. WHO/IASO/IOTF (2000) The Asia-Pacific Perspective: Redefining Obesity and its Treatment. Health Communications Australia, Melbourne.
18. Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). Journal of the American Medical Association, 285, 2486-2497.
19. de Ferranti, S.D., Gauvreau, K., Ludwig, D.S., et al. (2004) Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation, 110, 2494-2497. (Pubitemid 39407358)
20. Ministry of Health and Welfare, South Korea (2006) The Third Korea National Health and Nutrition Examination Survey (KNHANES III), 2005.
21. Böttner, A., Kratzsch, J., Müller, G., et al. (2004) Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. The Journal of Clinical Endocrinology and Metabolism, 89, 4053-4061. (Pubitemid 39071513)
22. Walldius, G., Jungner, I., Holme, I., et al. (2001) High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study. The Lancet, 358, 2026-2033. (Pubitemid 34084825)
23. Yusuf, S., Hawken, S., Ounpuu, S., et al. (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The Lancet, 364, 937-952. (Pubitemid 39208455)
24. Ley, S.H., Harris, S.B., Connelly, P.W., et al. (2010) Association of apolipoprotein B with incident type 2 diabetes in an aboriginal Canadian population. Clinical Chemistry, 56, 666-670.
25. Taylor, R.W., Jones, I.E., Williams, S.M., et al. (2000) Evaluation of waist circumference, waist-to-hip ratio, and the conicity index as screening tools for high trunk fat mass, as measured by dual-energy X-ray absorptiometry, in children aged 3-19 y. The American Journal of Clinical Nutrition, 72, 490-495. (Pubitemid 30620657)
26. Yan, W., Wang, X., Yao, H., et al. (2006) Waist-to-height ratio and BMI predict different cardiovascular risk factors in Chinese children. Diabetes Care, 29, 2760-2761. (Pubitemid 44912220)
27. Maffeis, C., Banzato, C., &, Talamini, G., (2008) Waist-to-height ratio, a useful index to identify high metabolic risk in overweight children. The Journal of Pediatrics, 152, 207-213.
28. Cossio, S., Messiah, S.E., Garibay-Nieto, N., et al. (2009) How do different indices of obesity correlate with cardiometabolic disease risk factors in multiethnic youths? Endocrine Practice, 15, 403-409.
29. Després, J.P., Lemieux, I., Bergeron, J., et al. (2008) Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 1039-1049.
30. Dickerman, R.D., McConathy, W.J., &, Zachariah, N.Y., (1997) Testosterone, sex hormone-binding globulin, lipoproteins, and vascular disease risk. Journal of Cardiovascular Risk, 4, 363-366. (Pubitemid 28078679)
31. Morrison, J.A., Sprecher, D.L., Biro, F.M., et al. (2000) Estradiol and testosterone effects on lipids in black and white boys aged 10 to 15 years. Metabolism, 49, 1124-1129.
32. Tsou, P.L., Jiang, Y.D., Chang, C.C., et al. (2004) Sex-related differences between adiponectin and insulin resistance in schoolchildren. Diabetes Care, 27, 308-313.
33. Page, S.T., Herbst, K.L., Amory, J.K., et al. (2005) Testosterone administration suppresses adiponectin levels in men. Journal of Andrology, 26, 85-92. (Pubitemid 39665280)
34. Sierra-Johnson, J., Romero-Corral, A., Somers, V.K., et al. (2007) ApoB/apoA-I ratio: an independent predictor of insulin resistance in US non-diabetic subjects. European Heart Journal, 28, 2637-2643. (Pubitemid 350071512)
35. Retnakaran, R., Zinman, B., Connelly, P.W., et al. (2006) Nontraditional cardiovascular risk factors in pediatric metabolic syndrome. The Journal of Pediatrics, 148, 176-182. (Pubitemid 43286757)
36. Wallenfeldt, K., Bokemark, L., Wikstrand, J., et al. (2004) Apolipoprotein B/apolipoprotein A-I in relation to the metabolic syndrome and change in carotid artery intima-media thickness during 3 years in middle-aged men. Stroke, 35, 2248-2252. (Pubitemid 39311244)
37. Juonala, M., Viikari, J.S., Kähönen, M., et al. (2008) Childhood levels of serum apolipoproteins B and A-I predict carotid intima-media thickness and brachial endothelial function in adulthood: the cardiovascular risk in young Finns study. Journal of the American College of Cardiology, 52, 293-299. (Pubitemid 351957853)
38. Sniderman, A.D., Blank, D., Zakarian, R., et al. (2003) Triglycerides and small dense LDL: the twin Achilles heels of the Friedewald formula. Clinical Biochemistry, 36, 499-504. (Pubitemid 37244010)