White blood cell count and psychomotor cognitive performance in the elderly

European Journal of Clinical Investigation

Volumn 41, Issue 5, 2011, Pages 513-520

  Kao, Tung Wei ^a   Chang, Yaw Wen ^a   Chou, Chih Chieh ^a   Hu, Jung ^b   Yu, Yau Hua ^c   Kuo, Hsu Ko ^d  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Cognition; Elderly; White blood cell

Indexed keywords

ADULT; AGED; ARTICLE; COGNITION; ELDERLY CARE; FEMALE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; QUESTIONNAIRE; SCORING SYSTEM;

AGED; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LEUKOCYTE COUNT; MALE; PSYCHOMOTOR PERFORMANCE; REGRESSION ANALYSIS;

EID: 79953740066     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2010.02438.x     Document Type: Article

References (37)

1. Shankar A, Klein BE, Klein R. Relationship between white blood cell count and incident hypertension. Am J Hypertens 2004;17:233-9.
2. Ohshita K, Yamane K, Hanafusa M, Mori H, Mito K, Okubo M et al. Elevated white blood cell count in subjects with impaired glucose tolerance. Diabetes Care 2004;27:491-6.
3. Festa A, D'Agostino R Jr, Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000;102:42-7.
4. Veronelli A, Laneri M, Ranieri R, Koprivec D, Vardaro D, Paganelli M et al. White blood cells in obesity and diabetes: effects of weight loss and normalization of glucose metabolism. Diabetes Care 2004;27:2501-2.
5. Lao XQ, Neil Thomas G, Jiang C, Zhang W, Adab P, Lam TH et al. White blood cell count and the metabolic syndrome in older Chinese: the Guangzhou Biobank Cohort Study. Atherosclerosis 2008;201:418-24.
6. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999;340:115-26.
7. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135-43.
8. Hoffman M, Blum A, Baruch R, Kaplan E, Benjamin M. Leukocytes and coronary heart disease. Atherosclerosis 2004;172:1-6.
9. Elkind MS, Cheng J, Boden-Albala B, Paik MC, Sacco RL. Elevated white blood cell count and carotid plaque thickness: the northern manhattan stroke study. Stroke 2001;32:842-9.
10. Karthikeyan VJ, Lip GY. White blood cell count and hypertension. J Hum Hypertens 2006;20:310-2.
11. Launer LJ. Demonstrating the case that AD is a vascular disease: epidemiologic evidence. Ageing Res Rev 2002;1:61-77.
12. Kalmijn S, Feskens EJ, Launer LJ, Stijnen T, Kromhout D. Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men. Diabetologia 1995;38:1096-102.
13. Gregg EW, Yaffe K, Cauley JA, Rolka DB, Blackwell TL, Narayan KM et al. Is diabetes associated with cognitive impairment and cognitive decline among older women? Study of Osteoporotic Fractures Research Group. Arch Intern Med 2000;160:174-80.
14. Yaffe K, Barrett-Connor E, Lin F, Grady D. Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol 2002;59:378-84.
15. Yaffe K, Lindquist K, Penninx BW, Simonsick EM, Pahor M, Kritchevsky S et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology 2003;61:76-80.
16. Dik MG, Jonker C, Hack CE, Smit JH, Comijs HC, Eikelenboom P. Serum inflammatory proteins and cognitive decline in older persons. Neurology 2005;64:1371-7.
17. Kuo HK, Yen CJ, Chang CH, Kuo CK, Chen JH, Sorond F. Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis. Lancet Neurol 2005;4:371-80.
18. Engelhart MJ, Geerlings MI, Meijer J, Kiliaan A, Ruitenberg A, van Swieten JC et al. Inflammatory proteins in plasma and the risk of dementia: the rotterdam study. Arch Neurol 2004;61:668-72.
19. Bethesda MD. National Center for Health Statistics. National Health and Nutrition Examination Survey (NHANES), 19992000. Available at Accessed on 12 December 2008.
20. Bethesda MD. National Center for Health Statistics. National Health and Nutrition Examination Survey (NHANES), 20012002. Available at Accessed on 12 December 2008.
21. Wechsler D. Manual for the Wechsler Adult Intelligence Scale-Revised. New York: The Psychological Corporation, 1981.
22. Hoth KF, Haley AP, Gunstad J, Paul RH, Poppas A, Jefferson AL et al. Elevated C-reactive protein is related to cognitive decline in older adults with cardiovascular disease. J Am Geriatr Soc 2008;56:1898-903.
23. Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Penttila IM, Helkala EL et al. Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age Ageing 2007;36:443-8.
24. Ravaglia G, Forti P, Maioli F, Brunetti N, Martelli M, Servadei L et al. Serum C-reactive protein and cognitive function in healthy elderly Italian community dwellers. J Gerontol A Biol Sci Med Sci 2005;60:1017-21.
25. Teunissen CE, van Boxtel MP, Bosma H, Bosmans E, Delanghe J, De Bruijn C et al. Inflammation markers in relation to cognition in a healthy aging population. J Neuroimmunol 2003;134:142-50.
26. Tong PC, Lee KF, So WY, Ng MH, Chan WB, Lo MK et al. White blood cell count is associated with macro- and microvascular complications in Chinese patients with type 2 diabetes. Diabetes Care 2004;27:216-22.
27. Yasunari K, Maeda K, Nakamura M, Yoshikawa J. Oxidative stress in leukocytes is a possible link between blood pressure, blood glucose, and C-reacting protein. Hypertension 2002;39:777-80.
28. Fuster V. Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation 1994;90:2126-46.
29. Ernst E, Hammerschmidt DE, Bagge U, Matrai A, Dormandy JA. Leukocytes and the risk of ischemic diseases. JAMA 1987;257:2318-24.
30. Hofmann MA, Schiekofer S, Kanitz M, Klevesath MS, Joswig M, Lee V et al. Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes. Diabetes Care 1998;21:1310-6.
31. Shanmugam N, Reddy MA, Guha M, Natarajan R. High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Diabetes 2003;52:1256-64.
32. Baud L, Ardaillou R. Tumor necrosis factor alpha in glomerular injury. Kidney Int Suppl 1994;45:S32-6.
33. Vallance P, Collier J, Bhagat K. Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link? Lancet 1997;349:1391-2.
34. Hingorani AD, Cross J, Kharbanda RK, Mullen MJ, Bhagat K, Taylor M et al. Acute systemic inflammation impairs endothelium-dependent dilatation in humans. Circulation 2000;102:994-9.
35. Vinkers DJ, Stek ML, van der Mast RC, de Craen AJ, Le Cessie S, Jolles J et al. Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age. Neurology 2005;65:107-12.
36. Pugh KG, Lipsitz LA. The microvascular frontal-subcortical syndrome of aging. Neurobiol Aging 2002;23:421-31.
37. Kuo HK, Lin LY, Yu YH. Microalbuminuria is a negative correlate for cognitive function in older adults with peripheral arterial disease: results from the U.S. National Health and Nutrition Examination Survey 1999-2002. J Intern Med 2007;262:562-70.