A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogs

PLoS Genetics

Volumn 7, Issue 3, 2011, Pages

  Olsson, Mia ^a   Meadows, Jennifer R S ^a   Truvé, Katarina ^b   Pielberg, Gerli Rosengren ^a   Puppo, Francesca ^c   Mauceli, Evan ^d   Quilez, Javier ^e   Tonomura, Noriko ^d   Zanna, Giordana ^e   Docampo, Maria José ^e   Bassols, Anna ^e   Avery, Anne C ^f   Karlsson, Elinor K ^d,g   Thomas, Anne ^h   Kastner, Daniel L ^c   Bongcam Rudloff, Erik ^a   Webster, Matthew T ^a   Sanchez, Armand ^e   Hedhammar, Åke ^b   Remmers, Elaine F ^c   Andersson, Leif ^a,b   Ferrer, Lluis ^e   Tintle, Linda ⁱ   Lindblad Toh, Kerstin ^a,d   more..

^a UPPSALA UNIVERSITY   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f Department of Environmental and Radiological Health Sciences   (United States)

^g HARVARD UNIVERSITY   (United States)

^h ANTAGENE Laboratory   (France)

ⁱ Wurtsboro Veterinary Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSAMINOGLYCAN; HYALURONIC ACID SYNTHASE 2; SYNTHETASE; UNCLASSIFIED DRUG; GLUCURONOSYLTRANSFERASE; HYALURONIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREEDING METHOD; CHINESE; CHROMOSOME 13; CONTROLLED STUDY; DOG; GENE DOSAGE; GENE DUPLICATION; GENE EXPRESSION REGULATION; GENE LOCATION; GENE MUTATION; GENE TARGETING; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC RISK; GENETIC STABILITY; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GENOME ANALYSIS; HEREDITARY PERIODIC FEVER; IMMUNE SYSTEM; INNATE IMMUNITY; NONHUMAN; PHENOTYPE; PLEIOTROPY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION; ANIMAL; ANIMAL DISEASE; BREEDING; DOG DISEASE; ENZYMOLOGY; FEVER; GENETIC PREDISPOSITION; GENETICS; METABOLISM; PATHOLOGY; SKIN; SYNDROME;

CANIS FAMILIARIS;

ANIMALS; BREEDING; DOG DISEASES; DOGS; FEVER; GENE DUPLICATION; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GLUCURONOSYLTRANSFERASE; HYALURONIC ACID; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SKIN; SYNDROME;

EID: 79953735868     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001332     Document Type: Article

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