Absence of BRAF and HRAS mutations in eruptive Spitz naevi

British Journal of Dermatology

Volumn 164, Issue 4, 2011, Pages 873-877

  Gantner, S ^a   Wiesner, T ^b   Cerroni, L ^b   Lurkin, I ^c   Zwarthoff, E C ^c   Landthaler, M ^a   Hafner, Christian ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; K RAS PROTEIN;

ADOLESCENT; ANAMNESIS; ARTICLE; CASE REPORT; CHROMOSOME ABERRATION; COMPARATIVE GENOMIC HYBRIDIZATION; DNA ISOLATION; EXCISION; GENE MUTATION; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; JUVENILE MELANOMA; MALE; MELANOCYTIC NEVUS; ONCOGENE H RAS; ONCOGENE N RAS; PAPULE; PRIORITY JOURNAL; RASH; SKIN DISCOLORATION;

ADOLESCENT; DNA MUTATIONAL ANALYSIS; GENES, RAS; HUMANS; MALE; MUTATION; NEVUS, EPITHELIOID AND SPINDLE CELL; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 79953720837     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2011.10210.x     Document Type: Article

References (21)

1. Kilinc Karaarslan I, Ozdemir F, Akalin T et al. Eruptive disseminated Spitz naevi: dermatoscopic features. Clin Exp Dermatol 2009; 34:e807-10.
2. Levy RM, Ming ME, Shapiro M et al. Eruptive disseminated Spitz nevi. J Am Acad Dermatol 2007; 57:519-23. (Pubitemid 47239140)
3. Rim JH, Won CH, Lee JS et al. A case of multiple disseminated eruptive Spitz nevi. J Dermatol 2002; 29:380-2.
4. Onsun N, Saracoglu S, Demirkesen C et al. Eruptive widespread Spitz nevi: can pregnancy be a stimulating factor? J Am Acad Dermatol 1999; 40:866-7.
5. Salmon-Ehr V, Belaich S, Tran C et al. Multiple disseminated eruptive Spitz nevi: a case (in French). Ann Dermatol Venereol 1993; 120:822-4. (Pubitemid 24019073)
6. Moulin G, Misery L, Balme B et al. Multiple eruptive Spitz nevi (in French). Ann Dermatol Venereol 1992; 119:551-3.
7. Paties CT, Borroni G, Rosso R et al. Relapsing eruptive multiple Spitz nevi or metastatic spitzoid malignant melanoma? Am J Dermatopathol 1987; 9:520-7.
8. Smith SA, Day CL Jr, Vander Ploeg DE. Eruptive widespread Spitz nevi. J Am Acad Dermatol 1986; 15:1155-9. (Pubitemid 17201522)
9. La Porta CA, Cardano R, Facchetti F et al. BRAF V599E mutation occurs in Spitz and Reed naevi. J Eur Acad Dermatol Venereol 2006; 20:1164-5. (Pubitemid 44425997)
10. Emley A, Yang S, Wajapeyee N et al. Oncogenic BRAF and the tumor suppressor IGFBP7 in the genesis of atypical spitzoid nevomelanocytic proliferations. J Cutan Pathol 2009; 37:344-9.
11. Fullen DR, Poynter JN, Lowe L et al. BRAF and NRAS mutations in spitzoid melanocytic lesions. Mod Pathol 2006; 19:1324-32. (Pubitemid 44423079)
12. Bastian BC, LeBoit PE, Pinkel D. Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol 2000; 157:967-72. (Pubitemid 32109388)
13. Bastian BC, Wesselmann U, Pinkel D et al. Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J Invest Dermatol 1999; 113:1065-9. (Pubitemid 30013354)
14. Indsto JO, Kumar S, Wang L et al. Low prevalence of RAS-RAF-activating mutations in Spitz melanocytic nevi compared with other melanocytic lesions. J Cutan Pathol 2007; 34:448-55. (Pubitemid 46791200)
15. Lurkin I, Stoehr R, Hurst CD et al. Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes. PLoS ONE 2010; 5:e8802.
16. Kompier LC, Lurkin I, van der Aa MN et al. FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy. PLoS ONE 2010; 5:e13821.
17. Wiesner T, Obenauf AC, Cota C et al. Alterations of the cell-cycle inhibitors p27(KIP1) and p16(INK4a) are frequent in blastic plasmacytoid dendritic cell neoplasms. J Invest Dermatol 2010; 130:1152-7.
18. Da Forno PD, Pringle JH, Fletcher A et al. BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance. Br J Dermatol 2009; 161:364-72.
19. Maertens O, Brems H, Vandesompele J et al. Comprehensive NF1 screening on cultured Schwann cells from neurofibromas. Hum Mutat 2006; 27:1030-40. (Pubitemid 44454056)
20. De Raedt T, Maertens O, Chmara M et al. Somatic loss of wild type NF1 allele in neurofibromas: comparison of NF1 microdeletion and non-microdeletion patients. Genes Chromosom Cancer 2006; 45:893-904. (Pubitemid 44360177)
21. Landi MT, Bauer J, Pfeiffer RM et al. MC1R germline variants confer risk for BRAF-mutant melanoma. Science 2006; 313:521-2. (Pubitemid 44148456)