Porcine Circovirus-2 Viral Load versus Lesions in Pigs: Perspectives for Post-weaning Multisystemic Wasting Syndrome

Journal of Comparative Pathology

Volumn 144, Issue 4, 2011, Pages 296-302

  Silva, F M F ^a   Silva Junior A ^a   Vidigal, P M P ^a   Oliveira, C R ^a   Viana, V W ^a   Silva, C H O ^a   Vargas, M I ^a   Fietto, J L R ^a   Almeida, M R ^a  

^a FEDERAL UNIVERSITY OF VIÇOSA   (Brazil)

Author keywords

Histopathology; PCV 2; Pigs; PMWS; Viral load

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CIRCOVIRUS; CONTROLLED STUDY; DISEASE SEVERITY; GLOMERULONEPHRITIS; HEART; HEPATITIS; HISTOPATHOLOGY; INGUINAL LYMPH NODE; INTERSTITIAL PNEUMONIA; KIDNEY; LIVER; LUNG; LYMPHOID CELL; MICROSCOPY; MYOCARDITIS; NONHUMAN; PORCINE CIRCOVIRUS 2; POSTWEANING MULTISYSTEMIC WASTING SYNDROME; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN; VIRUS LOAD;

ANIMALS; CIRCOVIRUS; DNA, VIRAL; HOST-PATHOGEN INTERACTIONS; LYMPH NODES; PORCINE POSTWEANING MULTISYSTEMIC WASTING SYNDROME; SWINE; VIRAL LOAD;

ANIMALIA; BACTERIA (MICROORGANISMS); PORCINE CIRCOVIRUS 2; SUIDAE;

EID: 79953719965     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcpa.2010.10.010     Document Type: Article

References (37)

1. Albina E., Truong C., Hutet E., Blanchard P., Cariolet R., et al. An experimental model for post-weaning multisystemic wasting syndrome (PMWS) in growing piglets. Journal of Comparative Pathology 2001, 125:292-303.
2. Allan G.M., Ellis J.A. Porcine circoviruses: a review. Journal of Veterinary Diagnostic Investigation 2000, 12:3-14.
3. Allan G.M., McNeilly F., Ellis J., Krakowka S., Meehan B., et al. Experimental infection of colostrum deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication. Archives of Virology 2000, 145:2421-2429.
4. Blanchard P., Mahe D., Cariolet R., Keranflec'h A., Baudouard M.A., et al. Protection of swine against post-weaning multisystemic wasting syndrome (PMWS) by porcine circovirus type 2 (PCV2) proteins. Vaccine 2003, 21:4565-4575.
5. Chae C. Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology. Veterinary Journal 2004, 168:41-49.
6. Chang H.W., Jeng C.R., Liu J.J., Lin T.L., Chang C.C., et al. Reduction of porcine reproductive and respiratory syndrome virus (PRRSV) infection in swine alveolar macrophages by porcine circovirus 2 (PCV2)-induced interferon-alpha. Veterinary Microbiology 2005, 108:167-177.
7. Chianini F., Majo N., Segales J., Dominguez J., Domingo M. Immunohistochemical characterisation of PCV2 associate lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology 2003, 94:63-75.
8. Chiarelli-Neto O., Yotoko K.S., Vidigal P.M., Silva F.M., Castro L.A., et al. Classification and putative origins of Brazilian porcine circovirus 2 inferred through phylogenetic and phylogeographical approaches. Virus Research 2009, 140:57-63.
9. Clark E.G., Ellis J.A., Allan G.M., Krakowka S. Post-weaning multisystemic wasting syndrome in swine. Infectious Diseases of Livestock 2004, 1374-1386. Oxford University Press, Oxford. J.A.W. Coetzer, R.C. Tustin (Eds.).
10. Corrêa A.M.R., Pescador C.A., Schmitz M., Zlotowski P., Rozza D.B., et al. Clinical and pathological aspects of swine circovirosis in Rio Grande do Sul, southern Brazil. Pesquisa Veterinária Brasileira 2006, 26:9-13.
11. Furuta Y., Ohtani F., Sawa H., Fukuda S., Inuyama Y. Quantitation of varicella-zoster virus DNA in patients with Ramsay Hunt syndrome and zoster sine herpete. Journal of Clinical Microbiology 2001, 39:2856-2859.
12. Gagnon C.A., del Castillo J.R., Music N., Fontaine G., Harel J., et al. Development and use of a multiplex real-time quantitative polymerase chain reaction assay for detection and differentiation of porcine circovirus-2 genotypes 2a and 2b in an epidemiological survey. Journal of Veterinary Diagnostic Investigation 2008, 20:545-558.
13. Grau-Roma L., Crisci E., Sibila M., Lopez-Soria S., Nofrarias M., et al. A proposal on porcine circovirus type 2 (PCV2) genotype definition and their relation with postweaning multisystemic wasting syndrome (PMWS) occurrence. Veterinary Microbiology 2008, 128:23-35.
14. Huang Y.Y., Walther I., Martinson S.A., Lopez A., Yason C., et al. Porcine circovirus 2 inclusion bodies in pulmonary and renal epithelial cells. Veterinary Pathology 2008, 45:640-644.
15. Júnior A.S., Castro L.A., Neto O.C., Silva F.M.F., Vidigal P.M.P., et al. Development and evaluation of a recombinant DNA vaccine candidate expressing porcine circovirus 2 structural protein. Pesquisa Veterinária Brasileira 2009, 29:76-82.
16. Kearns A.M., Guiver M., James V., King J. Development and evaluation of a real-time quantitative PCR for the detection of human cytomegalovirus. Journal of Virological Methods 2001, 95:121-131.
17. Kixmoller M., Ritzmann M., Eddicks M., Saalmuller A., Elbers K., et al. Reduction of PMWS-associated clinical signs and co-infections by vaccination against PCV2. Vaccine 2008, 26:3443-3451.
18. Krakowka S., Ellis J.A., Meehan B., Kennedy S., McNeilly F., et al. Viral wasting syndrome of swine: experimental reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus. Veterinary Pathology 2000, 37:254-263.
19. Lyoo K.S., Kim H.B., Joo H.S. Evaluation of a nested polymerase chain reaction assay to differentiate between two genotypes of porcine circovirus-2. Journal of Veterinary Diagnostic Investigation 2008, 20:283-288.
20. Madec F., Eveno E., Morvan P., Hamon L., Blanchard P., et al. Post-weaning multisystemic wasting syndrome (PMWS) in pigs in France: clinical observations from follow-up studies on affected farms. Livestock Production Science 2000, 63:223-233.
21. Meehan B.M., McNeilly F., Todd D., Kennedy S., Jewhurst V.A., et al. Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. Journal of General Virology 1998, 79:2171-2179.
22. Olvera A., Cortey M., Segales J. Molecular evolution of porcine circovirus type 2 genomes: phylogeny and clonality. Virology 2007, 357:175-185.
23. Olvera A., Sibila M., Calsamiglia M., Segales J., Domingo M. Comparison of porcine circovirus type 2 load in serum quantified by a real time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs. Journal of Virological Methods 2004, 117:75-80.
24. Opriessnig T., Fenaux M., Yu S., Evans R.B., Cavanaugh D., et al. Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus. Veterinary Microbiology 2004, 98:209-220.
25. Opriessnig T., Meng X.J., Halbur P.G. Porcine circovirus type 2-associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. Journal of Veterinary Diagnostic Investigation 2007, 19:591-615.
26. Opriessnig T., Thacker E.L., Yu S., Fenaux M., Meng X.J., et al. Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Veterinary Pathology 2004, 41:624-640.
27. Quintana J., Segales J., Rosell C., Calsamiglia M., Rodriguez-Arrioja G.M., et al. Clinical and pathological observations on pigs with postweaning multisystemic wasting syndrome. Veterinary Record 2001, 149:357-361.
28. Ramamoorthy S., Meng X.J. Porcine circoviruses: a minuscule yet mammoth paradox. Animal Health Research Reviews 2009, 10:1-20.
29. Rosell C., Segales J., Plana-Duran J., Balasch M., Rodriguez-Arrioja G.M., et al. Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. Journal of Comparative Pathology 1999, 120:59-78.
30. Rovira A., Balasch M., Segales J., Garcia L., Plana-Duran J., et al. Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2. Journal of Virology 2002, 76:3232-3239.
31. Segales J., Calsamiglia M., Olvera A., Sibila M., Badiella L., et al. Quantification of porcine circovirus type 2 (PCV2) DNA in serum and tonsillar, nasal, tracheo-bronchial, urinary and faecal swabs of pigs with and without postweaning multisystemic wasting syndrome (PMWS). Veterinary Microbiology 2005, 111:223-229.
32. Segales J., Domingo M. Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review. Veterinary Quarterly 2002, 24:109-124.
33. Segales J., Domingo M., Chianini F., Majo N., Dominguez J., et al. Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Veterinary Microbiology 2004, 98:151-158.
34. Segales J., Rosell C., Domingo M. Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease. Veterinary Microbiology 2004, 98:137-149.
35. Shibahara T., Sato K., Ishikawa Y., Kadota K. Porcine circovirus induces B lymphocyte depletion in pigs with wasting disease syndrome. Journal of Veterinary Medical Science 2000, 62:1125-1131.
36. Sorden S.D. Update on porcine circovirus and postweaning multisystemic wasting syndrome. Swine Health Production 2000, 8:133-136.
37. Yu S., Opriessnig T., Kitikoon P., Nilubol D., Halbur P.G., et al. Porcine circovirus type 2 (PCV2) distribution and replication in tissues and immune cells in early infected pigs. Veterinary Immunology and Immunopathology 2007, 115:261-272.