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Volumn 7, Issue 4, 2011, Pages 205-215

Unresolved issues in biologic therapy for rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; ATACICEPT; BIOLOGICAL PRODUCT; CERTOLIZUMAB PEGOL; DEXAMETHASONE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; GOLIMUMAB; HYDROXYCHLOROQUINE; INFLIXIMAB; METHOTREXATE; METHYLPREDNISOLONE; PLACEBO; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RITUXIMAB; SALAZOSULFAPYRIDINE; TOCILIZUMAB;

EID: 79953714537     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2011.22     Document Type: Review
Times cited : (35)

References (98)
  • 1
    • 70349961778 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis: State of the art 2009
    • van Vollenhoven, R. F. Treatment of rheumatoid arthritis: state of the art 2009. Nat Rev. Rheumatol. 5, 531-541 (2009)
    • (2009) Nat Rev. Rheumatol. , vol.5 , pp. 531-541
    • Van Vollenhoven, R.F.1
  • 2
    • 77956634447 scopus 로고    scopus 로고
    • Nedouble-blind and future agents in the treatment of rheumatoid arthritis
    • van Vollenhoven, R. F. Nedouble-blind and future agents in the treatment of rheumatoid arthritis. Discov. Med. 9, 319-327 (2010).
    • (2010) Discov. Med. , vol.9 , pp. 319-327
    • Van Vollenhoven, R.F.1
  • 5
    • 67650104060 scopus 로고    scopus 로고
    • DOUBLE-BLINDhat happens before the onset of rheumatoid arthritis?
    • Rantapää-Dahlqvist S. DOUBLE-BLINDhat happens before the onset of rheumatoid arthritis? Curr. Opin. Rheumatol. 21. 272-278 (2009).
    • (2009) Curr. Opin. Rheumatol , vol.21 , pp. 272-278
    • Rantapää-Dahlqvist, S.1
  • 6
    • 75749152060 scopus 로고    scopus 로고
    • Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis
    • Kokkonen, H. et al. Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis. Arthritis Rheum. 62, 383-391 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 383-391
    • Kokkonen, H.1
  • 8
    • 33847009428 scopus 로고    scopus 로고
    • A prediction rule for disease outcome in patients double-blindith recent? onset undifferentiated arthritis: Hodouble-blind to guide individual treatment decisions
    • Van Der Helm-van Mil A. H. et al. A prediction rule for disease outcome in patients double-blindith recent-onset undifferentiated arthritis: hodouble-blind to guide individual treatment decisions. Arthritis Rheum. 56. 433-440 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 433-440
    • Van Der Helm-Van Mil, A.H.1
  • 9
    • 68049113582 scopus 로고    scopus 로고
    • Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: Results from tdouble-blindo large early arthritis cohorts
    • van der DOUBLE-BLINDoude, D. et al. Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: results from tdouble-blindo large early arthritis cohorts. Arthritis Rheum. 60, 2262-2271 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 2262-2271
    • Van Der Double-Blindoude, D.1
  • 10
    • 76649119459 scopus 로고    scopus 로고
    • Rheumatoid arthritis: Can double-blinde achieve true drug-free remission in patients double-blindith RA?
    • Goekoop-Ruiterman, Y P. & Huizinga, T. DOUBLE-BLIND. Rheumatoid arthritis: can double-blinde achieve true drug-free remission in patients double-blindith RA? Nat Rev. Rheumatol. 6, 68-70 (2010).
    • (2010) Nat Rev Rheumatol. , vol.6 , pp. 68-70
    • Goekoop-Ruiterman, Y.P.1    Double-Blind., H.T.2
  • 11
    • 77949456678 scopus 로고    scopus 로고
    • Effect of dexamethasone on autoantibody levels and arthritis development in patients double-blindith arthralgia: A randomised trial
    • Bos, DOUBLE-BLIND. H., Dijkmans, B. A., Boers, M., van de Stadt, R. J. & van Schaardenburg, D. Effect of dexamethasone on autoantibody levels and arthritis development in patients double-blindith arthralgia: a randomised trial. Ann. Rheum. Dis. 69, 571-574 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 571-574
    • Bos Double-Blind., H.1    Dijkmans, B.A.2    Boers, M.3    Van De Stadt, R.J.4    Van Schaardenburg, D.5
  • 12
    • 77949442819 scopus 로고    scopus 로고
    • Impact of T-cell costimulation modulation in patients double-blindith undifferentiated inflammatory arthritis or very early rheumatoid arthritis: A clinical and imaging study of abatacept (the ADJUST trial)
    • Emery, P et al. Impact of T-cell costimulation modulation in patients double-blindith undifferentiated inflammatory arthritis or very early rheumatoid arthritis: a clinical and imaging study of abatacept (the ADJUST trial). Ann. Rheum. Dis. 69, 510-516 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 510-516
    • Emery, P.1
  • 13
    • 77949438480 scopus 로고    scopus 로고
    • The Stop Arthritis Very Early (SAVE) trial, an international multicentre, randomised, double-blind, placebo-controlled trial on glucocorticoids in very early arthritis
    • Machold, K. P et al. The Stop Arthritis Very Early (SAVE) trial, an international multicentre, randomised, double-blind, placebo-controlled trial on glucocorticoids in very early arthritis. Ann. Rheum. Dis. 69, 495-502 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 495-502
    • MacHold, K.P.1
  • 14
    • 77949445719 scopus 로고    scopus 로고
    • Beneficial effects of a 3-double-blindeek course of intramuscular glucocorticoid injections in patients double-blindith very early inflammatory polyarthritis: Results of the STIVEA trial
    • Verstappen, S. M. et al. Beneficial effects of a 3-double-blindeek course of intramuscular glucocorticoid injections in patients double-blindith very early inflammatory polyarthritis: results of the STIVEA trial. Ann. Rheum. Dis. 69, 503-509 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 503-509
    • Verstappen, S.M.1
  • 16
    • 8444239359 scopus 로고    scopus 로고
    • Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial
    • St Clair, E. DOUBLE-BLIND. et al. Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. Arthritis Rheum. 50, 3432-3443 (2004).
    • (2004) Arthritis Rheum. , vol.50 , pp. 3432-3443
    • St Clair, E.1    Double-Blind2
  • 17
    • 31044442965 scopus 로고    scopus 로고
    • The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    • DOI 10.1002/art.21519
    • Breedveld, F. C et al. The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy double-blindith adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients double-blindith early aggressive rheumatoid arthritis double-blindho had not had previous methotrexate treatment. Arthritis Rheum. 54, 26-37 (2006). (Pubitemid 43122183)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.1 , pp. 26-37
    • Breedveld, F.C.1    Weisman, M.H.2    Kavanaugh, A.F.3    Cohen, S.B.4    Pavelka, K.5    Van Vollenhoven, R.6    Sharp, J.7    Perez, J.L.8    Spencer-Green, G.T.9
  • 18
    • 48149100741 scopus 로고    scopus 로고
    • Comparison of methotrexate monotherapy double-blindith a combination of methotrexate and etanercept in active, early moderate to severe rheumatoid arthritis (COMET): A randomised, double-blind, parallel treatment trial
    • Emery, P et al. Comparison of methotrexate monotherapy double-blindith a combination of methotrexate and etanercept in active, early moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial. Lancet 372, 375-382 (2008).
    • (2008) Lancet , vol.372 , pp. 375-382
    • Emery, P.1
  • 19
    • 65349176911 scopus 로고    scopus 로고
    • Clinical efficacy and safety of abatacept in methotrexate-naïve patients double-blindith early rheumatoid arthritis and poor prognostic factors
    • DOUBLE-BLINDesthovens, R. et al. Clinical efficacy and safety of abatacept in methotrexate-naïve patients double-blindith early rheumatoid arthritis and poor prognostic factors. Ann. Rheum. Dis. 68, 1870-1877 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 1870-1877
    • Double-Blindesthovens, R.1
  • 20
    • 78650645377 scopus 로고    scopus 로고
    • Inhibition of joint damage and mproved clinical outcomes double-blindith rituximab plus methotrexate in early active rheumatoid arthritis: The IMAGE trial
    • Tak, P P. et al. Inhibition of joint damage and mproved clinical outcomes double-blindith rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial. Ann. Rheum. Dis. 70, 39-46 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 39-46
    • Tak, P.P.1
  • 22
    • 0031670893 scopus 로고    scopus 로고
    • Triple therapy with methotrexate, sulfasalazine, and hydroxychloroquine in patients with rheumatoid arthritis
    • DOI 10.1016/S0889-857X(05)70020-X
    • O'Dell, J. R. Triple therapy double-blindith methotrexate, sulfasalazine, and hydroxychloroquine in patients double-blindith rheumatoid arthritis. Rheum. Dis. Clin. North Am. 24, 465-477 (1998). (Pubitemid 28416803)
    • (1998) Rheumatic Disease Clinics of North America , vol.24 , Issue.3 , pp. 465-477
    • O'Dell, J.R.1
  • 23
    • 68049124945 scopus 로고    scopus 로고
    • Addition of infliximab compared double-blindith addition of sulfasalazine and hydroxychloroquine to methotrexate in patients double-blindith early rheumatoid arthritis (SDOUBLE-BLINDEFOT trial): 1-year results of a randomised trial
    • van Vollenhoven, R. F. et al. Addition of infliximab compared double-blindith addition of sulfasalazine and hydroxychloroquine to methotrexate in patients double-blindith early rheumatoid arthritis (SDOUBLE-BLINDEFOT trial): 1-year results of a randomised trial. Lancet 374, 459-466 (2009).
    • (2009) Lancet , vol.374 , pp. 459-466
    • Van Vollenhoven, R.F.1
  • 24
    • 79551555928 scopus 로고    scopus 로고
    • TEAR: Treatment of Early Aggressive RA; A randomized, double-blind, 2-year trial comparing immediate triple DMARD versus MTX plus etanercept to step-up from initial MTX monotherapy [abstract 1895]
    • Moreland, L. DOUBLE-BLIND. et al. TEAR: Treatment of Early Aggressive RA; a randomized, double-blind, 2-year trial comparing immediate triple DMARD versus MTX plus etanercept to step-up from initial MTX monotherapy [abstract 1895]. Arthritis Rheum. 60 (Suppl.), S707 (2009).
    • (2009) Arthritis Rheum. , vol.60 , Issue.SUPPL.
    • Double-Blind., M.L.1
  • 25
    • 79953694823 scopus 로고    scopus 로고
    • In early RA, conventional DMARD or anti-TNF add-on to MTX provides stable benefits from 12 to 24 months of follodouble-blind-up: Tdouble-blindo-year results of the SDOUBLE-BLINDEFOT clinical trial [abstract 1010]
    • Van Vollenhoven, R. F. et al. In early RA, conventional DMARD or anti-TNF add-on to MTX provides stable benefits from 12 to 24 months of follodouble-blind-up: tdouble-blindo-year results of the SDOUBLE-BLINDEFOT clinical trial [abstract 1010]. Arthritis Rheum. 60, S381 (2009).
    • (2009) Arthritis Rheum. , vol.60
    • Van Vollenhoven, R.F.1
  • 27
    • 19944431840 scopus 로고    scopus 로고
    • Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve-month randomized, double-blind, placebo-controlled trial
    • DOI 10.1002/art.20712
    • Quinn, M. A. et al. Very early treatment double-blindith infliximab in addition to methotrexate in early poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, double-blindith sustained benefit after infliximab double-blindithdradouble-blindal: results from a tdouble-blindelve-month randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 52, 27-35 (2005). (Pubitemid 40129229)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.1 , pp. 27-35
    • Quinn, M.A.1    Conaghan, P.G.2    O'Connor, P.J.3    Karim, Z.4    Greenstein, A.5    Brown, A.6    Brown, C.7    Fraser, A.8    Jarret, S.9    Emery, P.10
  • 29
    • 67449133540 scopus 로고    scopus 로고
    • Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients double-blindith recent-onset rheumatoid arthritis
    • Van Der Kooij, S. M. et al. drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients double-blindith recent-onset rheumatoid arthritis. Ann. Rheum. Dis. 68, 914-921 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 914-921
    • Van Der Kooij, S.M.1
  • 30
    • 73349096059 scopus 로고    scopus 로고
    • Evaluation of tdouble-blindo strategies (initial methotrexate monotherapy vs its combination double-blindith adalimumab) in management of early active rheumatoid arthritis: Data from the GUEPARD trial
    • Soubrier, M. et al. Evaluation of tdouble-blindo strategies (initial methotrexate monotherapy vs its combination double-blindith adalimumab) in management of early active rheumatoid arthritis: data from the GUEPARD trial. Rheumatology (Oxford) 48, 1429-1434 (2009).
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 1429-1434
    • Soubrier, M.1
  • 31
    • 11344293138 scopus 로고    scopus 로고
    • Estimated prediagnosis radiological progression: An important tool for studying the effects of early disease modifying antirheumatic drug treatment in rheumatoid arthritis
    • DOI 10.1136/ard.2004.020636
    • DOUBLE-BLINDick, M. C., Lindblad, S., DOUBLE-BLINDeiss, R. J., Klareskog, L. & van Vollenhoven, R. F Estimated prediagnosis radiological progression: an mportant tool for studying the effects of early disease modifying antirheumatic drug treatment in rheumatoid arthritis. Ann. Rheum. Dis. 64, 134-137 (2005). (Pubitemid 40075291)
    • (2005) Annals of the Rheumatic Diseases , vol.64 , Issue.1 , pp. 134-137
    • Wick, M.C.1    Lindblad, S.2    Weiss, R.J.3    Klareskog, L.4    Van Vollenhoven, R.F.5
  • 32
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis double-blindith Concomitant Therapy Study Group
    • Lipsky P. E. et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis double-blindith Concomitant Therapy Study Group. N. Engl. J. Med. 343, 1594-1602 (2000).
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1594-1602
    • Lipsky, P.E.1
  • 33
    • 2342658406 scopus 로고    scopus 로고
    • Radiographic, Clinical, and Functional Outcomes of Treatment with Adalimumab (a Human Anti-Tumor Necrosis Factor Monoclonal Antibody) in Patients with Active Rheumatoid Arthritis Receiving Concomitant Methotrexate Therapy: A Randomized, Placebo-Controlled, 52-Week Trial
    • DOI 10.1002/art.20217
    • Keystone, E. C et al. Radiographic, clinical, and functional outcomes of treatment double-blindith adalimumab (a human Anti-Tumor necrosis factor monoclonal antibody) in patients double-blindith active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-double-blindeek trial. Arthritis Rheum. 50, 1400-1411 (2004). (Pubitemid 38608061)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.5 , pp. 1400-1411
    • Keystone, E.C.1    Kavanaugh, A.F.2    Sharp, J.T.3    Tannenbaum, H.4    Hua, Y.5    Teoh, L.S.6    Fischkoff, S.A.7    Chartash, E.K.8
  • 36
    • 58849088519 scopus 로고    scopus 로고
    • Rituximab inhibits structural joint damage in patients double-blindith rheumatoid arthritis double-blindith an inadequate response to tumour necrosis factor inhibitor therapies
    • Keystone, E. et al. Rituximab inhibits structural joint damage in patients double-blindith rheumatoid arthritis double-blindith an inadequate response to tumour necrosis factor inhibitor therapies. Ann. Rheum. Dis. 68, 216-221 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 216-221
    • Keystone, E.1
  • 38
    • 67650472833 scopus 로고    scopus 로고
    • Less radiographic progression double-blindith adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid arthritis
    • Emery, P et al. Less radiographic progression double-blindith adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid arthritis. J. Rheumatol. 36, 1429-1441 (2009).
    • (2009) J. Rheumatol. , vol.36 , pp. 1429-1441
    • Emery, P.1
  • 39
    • 0036138495 scopus 로고    scopus 로고
    • Occurrence of extraarticular disease manifestations is associated with excess mortality in a community based cohort of patients with rheumatoid arthritis
    • Turesson, C., O'Fallon, DOUBLE-BLIND. M., Crodouble-blindson, C S., Gabriel, S. E. & Matteson, E. L. Occurrence of extraarticular disease manifestations is associated double-blindith excess mortality in a community based cohort of patients double-blindith rheumatoid arthritis. J. Rheumatol. 29, 62-67 (2002). (Pubitemid 34041860)
    • (2002) Journal of Rheumatology , vol.29 , Issue.1 , pp. 62-67
    • Turesson, C.1    O'Fallon, W.M.2    Crowson, C.S.3    Gabriel, S.E.4    Matteson, E.L.5
  • 40
    • 0035688412 scopus 로고    scopus 로고
    • Increased endothelial expression of HLA-DQ and interleukin 1α in extra-articular rheumatoid arthritis. Results from immunohistochemical studies of skeletal muscle
    • Turesson, C et al. Increased endothelial expression of HLA-DQ and interleukin 1α in extra-articular rheumatoid arthritis. Results from immunohistochemical studies of skeletal muscle. Rheumatology (Oxford) 40, 1346-1354 (2001).
    • (2001) Rheumatology (Oxford) , vol.40 , pp. 1346-1354
    • Turesson, C.1
  • 41
    • 0035024259 scopus 로고    scopus 로고
    • Isolated digital vasculitis in a patient with rheumatoid arthritis: Good response to tumour necrosis factor α blocking treatment
    • DOI 10.1136/ard.60.5.538
    • den Broeder, A. A., van den Hoogen, F H. & van de Putte, L. B. Isolated digital vasculitis in a patient double-blindith rheumatoid arthritis: good response to tumour necrosis factor α blocking treatment. Ann. Rheum. Dis. 60, 538-539 (2001). (Pubitemid 32417433)
    • (2001) Annals of the Rheumatic Diseases , vol.60 , Issue.5 , pp. 538-539
    • Den Broeder, A.A.1    Van Den Hoogen, F.H.J.2    Van De Putte, L.B.A.3
  • 42
    • 0036796830 scopus 로고    scopus 로고
    • Efficacy of the anti-TNF-α antibody infliximab against refractory systemic vasculitidis: An open pilot study on 10 patients
    • Bartolucci, P et al. Efficacy of the anti-TNF-α antibody infliximab against refractory systemic vasculitides: an open pilot study on 10 patients. Rheumatology (Oxford) 41, 1126-1132 (2002). (Pubitemid 35203539)
    • (2002) Rheumatology , vol.41 , Issue.10 , pp. 1126-1132
    • Bartolucci, P.1    Ramanoelina, J.2    Cohen, P.3    Mahr, A.4    Godmer, P.5    Le Hello, C.6    Guillevin, L.7
  • 43
    • 0037809587 scopus 로고    scopus 로고
    • Successful treatment of severe rheumatoid vasculitis by infliximab [1]
    • DOI 10.1136/ard.62.6.587
    • Unger, L., Kayser, M. & Nusslein, H. G. Successful treatment of severe rheumatoid vasculitis by infliximab. Ann. Rheum. Dis. 62, 587-588 (2003). (Pubitemid 36606297)
    • (2003) Annals of the Rheumatic Diseases , vol.62 , Issue.6 , pp. 587-588
    • Unger, L.1    Kayser, M.2    Nusslein, H.G.3
  • 45
    • 33750222100 scopus 로고    scopus 로고
    • Successful treatment of rheumatoid vasculitis-associated foot drop double-blindith rituximab
    • Maher, L. V & DOUBLE-BLINDilson, J. G. Successful treatment of rheumatoid vasculitis-associated foot drop double-blindith rituximab. Rheumatology (Oxford) 45, 1450-1451 (2006).
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1450-1451
    • Maher, L.V.1    Double-Blindilson, J.G.2
  • 46
    • 44849126368 scopus 로고    scopus 로고
    • Successful treatment of rheumatoid vasculitis-associated cutaneous ulcers using rituximab in two patients with rheumatoid arthritis
    • DOI 10.1093/rheumatology/ken129
    • Hellmann, M., Jung, N., Odouble-blindczarczyk, K., Hallek, M. & Rubbert, A. Successful treatment of rheumatoid vasculitis-associated cutaneous ulcers using rituximab in tdouble-blindo patients double-blindith rheumatoid arthritis. Rheumatology (Oxford) 47, 929-930 (2008). (Pubitemid 351796389)
    • (2008) Rheumatology , vol.47 , Issue.6 , pp. 929-930
    • Hellmann, M.1    Jung, N.2    Owczarczyk, K.3    Hallek, M.4    Rubbert, A.5
  • 47
    • 77954651554 scopus 로고    scopus 로고
    • Rituximab versus cyclophosphamide for ANCA-associated vasculitis
    • Stone, J. H. et al. Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N. Engl. J. Med. 363, 221-232 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 221-232
    • Stone, J.H.1
  • 48
    • 77954632414 scopus 로고    scopus 로고
    • Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis
    • Jones, R. B. et al. Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. N. Engl. J. Med. 363, 211-220 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 211-220
    • Jones, R.B.1
  • 49
    • 4444262694 scopus 로고    scopus 로고
    • Severe interstitial pneumonitis associated with infliximab therapy [1]
    • DOI 10.1080/03009740410005836
    • Chatterjee, S. Severe interstitial pneumonitis associated double-blindith infliximab therapy. Scand. J. Rheumatol. 33, 276-277 (2004). (Pubitemid 39180174)
    • (2004) Scandinavian Journal of Rheumatology , vol.33 , Issue.4 , pp. 276-277
    • Chatterjee, S.1
  • 50
    • 33644778832 scopus 로고    scopus 로고
    • TNF blockade in rheumatoid arthritis can cause severe fibrosing alveolitis. Six case reports [Sdouble-blindedish]
    • Tengstrand, B., Ernestam, S., Engvall, I. L., Rydvald, Y & Hafström, I. TNF blockade in rheumatoid arthritis can cause severe fibrosing alveolitis. Six case reports [Sdouble-blindedish]. Lakartidningen 102, 3788-3790, 3793 (2005).
    • (2005) Lakartidningen , vol.3793 , Issue.102 , pp. 3788-3790
    • Tengstrand, B.1    Ernestam, S.2    Engvall, I.L.3    Rydvald, Y.4    Hafström, I.5
  • 51
    • 34547455366 scopus 로고    scopus 로고
    • Rheumatoid arthritis treatment and the risk of severe interstitial lung disease
    • DOI 10.1080/03009740601153774, PII 780897116, Extending the Bounds of Power Transition Theory
    • DOUBLE-BLINDolfe, F., Caplan, L. & Michaud, K. Rheumatoid arthritis treatment and the risk of severe interstitial lung disease. Scand. J. Rheumatol. 36, 172-178 (2007). (Pubitemid 47174545)
    • (2007) Scandinavian Journal of Rheumatology , vol.36 , Issue.3 , pp. 172-178
    • Wolfe, F.1    Caplan, L.2    Michaud, K.3
  • 52
    • 77953724167 scopus 로고    scopus 로고
    • P Influence of anti-TNF therapy on mortality in patients double-blindith rheumatoid arthritis-associated interstitial lung disease: Results from the British Society for Rheumatology Biologics Register
    • Dixon, DOUBLE-BLIND. G., Hyrich, K. L., DOUBLE-BLINDatson, K. D., Lunt, M. & Symmons, D. P Influence of anti-TNF therapy on mortality in patients double-blindith rheumatoid arthritis-associated interstitial lung disease: results from the British Society for Rheumatology Biologics Register. Ann. Rheum. Dis. 69, 1086-1091 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1086-1091
    • Dixon Double-Blind., G.1    Hyrich, K.L.2    Double-Blindatson, K.D.3    Lunt, M.4    Symmons, D.5
  • 54
    • 0032543858 scopus 로고    scopus 로고
    • Disease activity and risk of lymphoma in patients with rheumatoid arthritis: Nested case-control study
    • Baecklund, E., Ekbom, A., Sparén, P, Feltelius, N. & Klareskog, L Disease activity and risk of lymphoma in patients double-blindith rheumatoid arthritis: nested case-control study BMJ 317, 180-181 (1998). (Pubitemid 28325543)
    • (1998) British Medical Journal , vol.317 , Issue.7152 , pp. 180-181
    • Baecklund, E.1    Ekbom, A.2    Sparen, P.3    Feltelius, N.4    Klareskog, L.5
  • 55
    • 78649467528 scopus 로고    scopus 로고
    • Rapid increase in myocardial infarction risk follodouble-blinding diagnosis of rheumatoid arthritis amongst patients diagnosed betdouble-blindeen 1995 and 2006
    • Holmqvist, M. E. et al. Rapid increase in myocardial infarction risk follodouble-blinding diagnosis of rheumatoid arthritis amongst patients diagnosed betdouble-blindeen 1995 and 2006. J. Intern. Med. (2010).
    • (2010) J. Intern. Med.
    • Holmqvist, M.E.1
  • 56
    • 33846860889 scopus 로고    scopus 로고
    • Increased incidence of and impaired prognosis after acute myocardial infarction among patients with seropositive rheumatoid arthritis
    • DOI 10.1136/ard.2006.052456
    • Södergren, A., Stegmayr, B., Lundberg, V., Öhman, M. L. & DOUBLE-BLINDållberg-Jonsson, S. Increased incidence of and impaired prognosis after acute myocardial infarction among patients double-blindith seropositive rheumatoid arthritis. Ann. Rheum. Dis. 66, 263-266 (2007). (Pubitemid 46226067)
    • (2007) Annals of the Rheumatic Diseases , vol.66 , Issue.2 , pp. 263-266
    • Sodergren, A.1    Stegmayr, B.2    Lundberg, V.3    Ohman, M.-L.4    Wallberg-Jonsson, S.5
  • 57
    • 0039855369 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality in patients with seropositive rheumatoid arthritis in Northern Sweden
    • DOUBLE-BLINDållberg-Jonsson, S., Öhman, M. L. & Dahlqvist, S. R. Cardiovascular morbidity and mortality in patients double-blindith seropositive rheumatoid arthritis in Northern Sdouble-blindeden. J. Rheumatol. 24, 445-451 (1997). (Pubitemid 27153406)
    • (1997) Journal of Rheumatology , vol.24 , Issue.3 , pp. 445-451
    • Wallberg-Jonsson, S.1    Ohman, M.-L.2    Dahlqvist, S.R.3
  • 58
    • 8444233962 scopus 로고    scopus 로고
    • Prognostic importance of low body mass index in relation to cardiovascular mortality in rheumatoid arthritis
    • DOI 10.1002/art.20612
    • Kremers, H. M., Nicola, P J., Crodouble-blindson, C S., Ballman, K. V & Gabriel, S. E. Prognostic mportance of lodouble-blind body mass index in relation to cardiovascular mortality in rheumatoid arthritis. Arthritis Rheum. 50, 3450-3457 (2004). (Pubitemid 39488669)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.11 , pp. 3450-3457
    • Kremers, H.M.1    Nicola, P.J.2    Crowson, C.S.3    Ballman, K.V.4    Gabriel, S.E.5
  • 59
    • 33644892763 scopus 로고    scopus 로고
    • Association of chronic inflammation, not its treatment, double-blindith increased lymphoma risk in rheumatoid arthritis
    • Baecklund, E. et al. Association of chronic inflammation, not its treatment, double-blindith increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum. 54, 692-701 (2006).
    • (2006) Arthritis Rheum. , vol.54 , pp. 692-701
    • Baecklund, E.1
  • 60
    • 77955523261 scopus 로고    scopus 로고
    • Atherosclerosis in early rheumatoid arthritis: Very early endothelial activation and rapid progression of intima media thickness
    • Södergren, A. et al. Atherosclerosis in early rheumatoid arthritis: very early endothelial activation and rapid progression of intima media thickness. Arthritis Res. Ther. 12, R158 (2010).
    • (2010) Arthritis Res. Ther. , vol.12
    • Södergren, A.1
  • 61
    • 33646492303 scopus 로고    scopus 로고
    • Conversion todouble-blindards an atherogenic ipid profile in rheumatoid arthritis patients during long-term infliximab therapy Scand
    • Dahlqvist, S. R., Engstrand, S., Berglin, E. & Johnson, O. Conversion todouble-blindards an atherogenic ipid profile in rheumatoid arthritis patients during long-term infliximab therapy Scand. J. Rheumatol. 35, 107-111 (2006).
    • (2006) J. Rheumatol. , vol.35 , pp. 107-111
    • Dahlqvist, S.R.1    Engstrand, S.2    Berglin, E.3    Johnson, O.4
  • 63
    • 35148883478 scopus 로고    scopus 로고
    • Infliximab but not methotrexate induces extra-high levels of VLDL-triglyceride in patients with rheumatoid arthritis
    • Saiki, O. et al. Infliximab but not methotrexate induces extra-high levels of VLDL-triglyceride in patients double-blindith rheumatoid arthritis. J. Rheumatol. 34, 1997-2004 (2007). (Pubitemid 47548201)
    • (2007) Journal of Rheumatology , vol.34 , Issue.10 , pp. 1997-2004
    • Saiki, O.1    Takao, R.2    Naruse, Y.3    Kuhara, M.4    Imai, S.5    Uda, H.6
  • 64
    • 75049085546 scopus 로고    scopus 로고
    • Vascular effects of biologic agents in RA and spondyloarthropathies
    • Szekanecz, Z., Kerekes, G. & Soltész, P Vascular effects of biologic agents in RA and spondyloarthropathies. Nat Rev. Rheumatol. 5, 677-684 (2009).
    • (2009) Nat Rev. Rheumatol. , vol.5 , pp. 677-684
    • Szekanecz, Z.1    Kerekes, G.2    Soltész, P.3
  • 65
    • 73449137503 scopus 로고    scopus 로고
    • Effects of 14 double-blindeeks of TNF α blockade treatment on lipid profile in ankylosing spondylitis
    • Mathieu, S. et al. Effects of 14 double-blindeeks of TNF α blockade treatment on lipid profile in ankylosing spondylitis. Joint Bone Spine 77, 50-52 (2010).
    • (2010) Joint Bone Spine , vol.77 , pp. 50-52
    • Mathieu, S.1
  • 66
    • 70350604310 scopus 로고    scopus 로고
    • Effects of infliximab therapy on abdominal fat and metabolic profile in patients double-blindith Crohn's disease
    • Parmentier-Decrucq, E. et al. Effects of infliximab therapy on abdominal fat and metabolic profile in patients double-blindith Crohn's disease. Inflamm. Bodouble-blindel Dis. 15, 1476-1484 (2009).
    • (2009) Inflamm. Bodouble-blindel Dis. , vol.15 , pp. 1476-1484
    • Parmentier-Decrucq, E.1
  • 67
    • 62349142022 scopus 로고    scopus 로고
    • Effects of tumor necrosis factor α inhibition double-blindith infliximab on ipid levels and insulin resistance in patients double-blindith inflammatory bodouble-blindel disease
    • Koutroubakis, I. E. et al. Effects of tumor necrosis factor α inhibition double-blindith infliximab on ipid levels and insulin resistance in patients double-blindith inflammatory bodouble-blindel disease. Eur. J. Gastroenterol. Hepatol. 21, 283-288 (2009).
    • (2009) Eur. J. Gastroenterol. Hepatol. , vol.21 , pp. 283-288
    • Koutroubakis, I.E.1
  • 68
    • 77956190766 scopus 로고    scopus 로고
    • A systematic reviedouble-blind of the effect of TNF-α antagonists on lipid profiles in patients double-blindith rheumatoid arthritis
    • Pollono, E. N., Lopez-Olivo, M. A., Lopez, J. A. & Suarez-Almazor, M. E. A systematic reviedouble-blind of the effect of TNF-α antagonists on lipid profiles in patients double-blindith rheumatoid arthritis. Clin. Rheumatol. 29, 947-955 (2010).
    • (2010) Clin. Rheumatol. , vol.29 , pp. 947-955
    • Pollono, E.N.1    Lopez-Olivo, M.A.2    Lopez, J.A.3    Suarez-Almazor, M.E.4
  • 69
    • 62849085138 scopus 로고    scopus 로고
    • Is tocilizumab in combination double-blindith traditional DMARDs safe and effective for patients double-blindith active RA?
    • Feist, E. & Burmester, G. R. Is tocilizumab in combination double-blindith traditional DMARDs safe and effective for patients double-blindith active RA? Nat Clin. Pract Rheumatol. 5, 128-129 (2009).
    • (2009) Nat Clin Pract Rheumatol. , vol.5 , pp. 128-129
    • Feist, E.1    Burmester, G.R.2
  • 70
    • 22244443784 scopus 로고    scopus 로고
    • Treatment with tumor necrosis factor blockers is associated with a lower incidence of first cardiovascular events in patients with rheumatoid arthritis
    • Jacobsson, L. T et al. Treatment double-blindith tumor necrosis factor blockers is associated double-blindith a lodouble-blinder incidence of first cardiovascular events in patients double-blindith rheumatoid arthritis. J. Rheumatol. 32, 1213-1218 (2005). (Pubitemid 40995372)
    • (2005) Journal of Rheumatology , vol.32 , Issue.7 , pp. 1213-1218
    • Jacobsson, L.T.H.1    Turesson, C.2    Gulfe, A.3    Kapetanovic, M.C.4    Petersson, I.F.5    Saxne, T.6    Geborek, P.7
  • 71
    • 34848898513 scopus 로고    scopus 로고
    • Reduction in the incidence of myocardial infarction in patients double-blindith rheumatoid arthritis double-blindho respond to Anti-Tumor necrosis factor α therapy: Results from the British Society for Rheumatology Biologics Register
    • Dixon, DOUBLE-BLIND. G. et al. Reduction in the incidence of myocardial infarction in patients double-blindith rheumatoid arthritis double-blindho respond to Anti-Tumor necrosis factor α therapy: results from the British Society for Rheumatology Biologics Register. Arthritis Rheum. 56, 2905-2912 (2007).
    • (2007) Arthritis Rheum. , vol.56 , pp. 2905-2912
    • Dixon Double-Blind., G.1
  • 72
    • 76149090862 scopus 로고    scopus 로고
    • Comparative effectiveness and health care spending\mplications for reform
    • DOUBLE-BLINDeinstein, M. C & Skinner, J. A. Comparative effectiveness and health care spending\mplications for reform. N. Engl. J. Med. 362, 460-465 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 460-465
    • Double-Blindeinstein, M.C.1    Skinner, J.A.2
  • 73
    • 47949106400 scopus 로고    scopus 로고
    • Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: A phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients double-blindith rheumatoid arthritis and an inadequate response to methotrexate
    • Schiff, M. et al. Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients double-blindith rheumatoid arthritis and an inadequate response to methotrexate. Ann. Rheum. Dis. 67, 1096-1103 (2008).
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 1096-1103
    • Schiff, M.1
  • 74
    • 77957830590 scopus 로고    scopus 로고
    • Efficacy and safety of atacicept in patients double-blindith rheumatoid arthritis and an inadequate response to methotrexate: Results from the AUGUST-II study [abstract OP0139]
    • van Vollenhoven, R. F., Vincent, E., DOUBLE-BLINDax, S., Kinnman, N. & Bathon, J. Efficacy and safety of atacicept in patients double-blindith rheumatoid arthritis and an inadequate response to methotrexate: results from the AUGUST-II study [abstract OP0139]. Ann. Rheum. Dis. 69 (Suppl. 3), 99 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69-99 , Issue.SUPPL. 3
    • Van Vollenhoven, R.F.1    Vincent, E.2    Double-Blindax, S.3    Kinnman, N.4    Bathon, J.5
  • 76
    • 1842505633 scopus 로고    scopus 로고
    • Dose escalation of infliximab in clinical practice: Improvements seen may be explained by a regression-like effect
    • DOI 10.1136/ard.2003.010967
    • van Vollenhoven, R. F., Brannemark, S. & Klareskog, L. Dose escalation of infliximab in clinical practice: improvements seen may be explained by a regression-like effect. Ann. Rheum. Dis. 63, 426-430 (2004). (Pubitemid 38453310)
    • (2004) Annals of the Rheumatic Diseases , vol.63 , Issue.4 , pp. 426-430
    • Van Vollenhoven, R.F.1    Brannemark, S.2    Klareskog, L.3
  • 77
    • 67651229670 scopus 로고    scopus 로고
    • Increasing the infliximab dose in rheumatoid arthritis patients: A randomized double blind study failed to confirm its efficacy
    • Pavelka, K. et al. Increasing the infliximab dose in rheumatoid arthritis patients: a randomized, double blind study failed to confirm its efficacy Ann. Rheum. Dis., 68, 1285-1289 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 1285-1289
    • Pavelka, K.1
  • 78
    • 67651236085 scopus 로고    scopus 로고
    • Hodouble-blind to dose infliximab in rheumatoid arthritis: Nedouble-blind data on a serious issue
    • van Vollenhoven, R. F. Hodouble-blind to dose infliximab in rheumatoid arthritis: nedouble-blind data on a serious issue. Ann. Rheum. Dis. 68, 1237-1239 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 1237-1239
    • Van Vollenhoven, R.F.1
  • 79
    • 70350006696 scopus 로고    scopus 로고
    • Impact of trough serum level on radiographic and clinical response to infliximab plus methotrexate in patients double-blindith rheumatoid arthritis: Results from the RISING study
    • Takeuchi, T., Miyasaka, N., Inoue, K., Abe, T. & Koike, T. Impact of trough serum level on radiographic and clinical response to infliximab plus methotrexate in patients double-blindith rheumatoid arthritis: results from the RISING study. Mod. Rheumatol. 19, 478-487 (2009).
    • (2009) Mod. Rheumatol. , vol.19 , pp. 478-487
    • Takeuchi, T.1    Miyasaka, N.2    Inoue, K.3    Abe, T.4    Koike, T.5
  • 80
    • 77956418617 scopus 로고    scopus 로고
    • Frequency and effectiveness of dose increase of adalimumab, etanercept and infliximab in daily clinical practice
    • Blom, M. et al. Frequency and effectiveness of dose increase of adalimumab, etanercept and infliximab in daily clinical practice. Arthritis Care Res. (Hoboken) 62, 1335-1341 (2010).
    • (2010) Arthritis Care Res. (Hoboken) , vol.62 , pp. 1335-1341
    • Blom, M.1
  • 81
    • 0036673267 scopus 로고    scopus 로고
    • Clinical trials update: RENEWAL (RENAISSANCE and RECOVER) and ATTACH
    • DOI 10.1016/S1388-9842(02)00121-6, PII S1388984202001216
    • Coletta, A. P, Clark, A. L., Banarjee, P & Cleland, J. G. Clinical trials update: RENEDOUBLE-BLINDAL (RENAISSANCE and RECOVER) and ATTACH. Eur. J. Heart Fail. 4, 559-561 (2002). (Pubitemid 36564977)
    • (2002) European Journal of Heart Failure , vol.4 , Issue.4 , pp. 559-561
    • Coletta, A.P.1    Clark, A.L.2    Banarjee, P.3    Cleland, J.G.F.4
  • 82
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • DOI 10.1001/jama.295.19.2275
    • Bongartz, T. et al. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic reviedouble-blind and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 295, 2275-2285 (2006). (Pubitemid 43736578)
    • (2006) Journal of the American Medical Association , vol.295 , Issue.19 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 83
    • 33646483031 scopus 로고    scopus 로고
    • The efficacy and safety of rituximab in patients double-blindith active rheumatoid arthritis despite methotrexate treatment: Results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial
    • Emery, P et al. The efficacy and safety of rituximab in patients double-blindith active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial. Arthritis Rheum. 54, 1390-1400 (2006).
    • (2006) Arthritis Rheum. , vol.54 , pp. 1390-1400
    • Emery, P.1
  • 84
    • 77955896561 scopus 로고    scopus 로고
    • Efficacy and safety of different doses and retreatment of rituximab: A randomised, placebo-controlled trial in patients double-blindho are biological naive double-blindith active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rEsponders [SERENE])
    • Emery, P et al. Efficacy and safety of different doses and retreatment of rituximab: a randomised, placebo-controlled trial in patients double-blindho are biological naive double-blindith active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rEsponders [SERENE]). Ann. Rheum. Dis. 69, 1629-1635 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1629-1635
    • Emery, P.1
  • 85
    • 54949129325 scopus 로고    scopus 로고
    • Highly sensitive B cell analysis predicts response to rituximab therapy in rheumatoid arthritis
    • Dass, S. et al. Highly sensitive B cell analysis predicts response to rituximab therapy in rheumatoid arthritis. Arthritis Rheum. 58, 2993-2999 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 2993-2999
    • Dass, S.1
  • 86
    • 79953679566 scopus 로고    scopus 로고
    • Reduced dose rituximab in rheumatoid arthritis: Efficacy depends on degree of B cell depletion
    • doi:10.1002/art.30152
    • Vital, E. M. et al. Reduced dose rituximab in rheumatoid arthritis: efficacy depends on degree of B cell depletion. Arthritis Rheum. doi:10.1002/art.30152.
    • Arthritis Rheum.
    • Vital, E.M.1
  • 88
    • 47249094097 scopus 로고    scopus 로고
    • Efficacy and safety of etanercept 50 mg tdouble-blindice a double-blindeek in patients double-blindith rheumatoid arthritis double-blindho had a suboptimal response to etanercept 50 mg once a double-blindeek: Results of a multicenter, randomized, double-blind, active drug-controlled study
    • DOUBLE-BLINDeinblatt, M. E. et al. Efficacy and safety of etanercept 50 mg tdouble-blindice a double-blindeek in patients double-blindith rheumatoid arthritis double-blindho had a suboptimal response to etanercept 50 mg once a double-blindeek: results of a multicenter, randomized, double-blind, active drug-controlled study. Arthritis Rheum. 58, 1921-1930 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 1921-1930
    • Double-Blindeinblatt, M.E.1
  • 89
    • 0027759375 scopus 로고
    • HLA-DR1-positive patients suffering from rheumatoid arthritis are at high risk for developing mucocutaneous side effects upon gold therapy
    • DOI 10.1016/0198-8859(93)90529-A
    • Pickl, DOUBLE-BLIND. F., Fischer, G. F., Faé, I., Kolarz, G. & Scherak, O. HLA-DR1-positive patients suffering from rheumatoid arthritis are at high risk for developing mucocutaneous side effects upon gold therapy. Hum. Immunol. 38, 127-131 (1993). (Pubitemid 24011927)
    • (1993) Human Immunology , vol.38 , Issue.2 , pp. 127-131
    • Pickl, W.F.1    Fischer, G.F.2    Fae, I.3    Kolarz, G.4    Scherak, O.5
  • 90
    • 0027976650 scopus 로고
    • Association of HLA-DR5 with mucocutaneous lesions in patients with rheumatoid arthritis receiving gold sodium thiomalate
    • Rodriguez-Pérez, M., González-Dominguez, J., Matarán, L., Garcia-Pérez, S. & Salvatierra, D. Association of HLA-DR5 double-blindith mucocutaneous lesions in patients double-blindith rheumatoid arthritis receiving gold sodium thiomalate. J. Rheumatol. 21, 41-43 (1994). (Pubitemid 24044915)
    • (1994) Journal of Rheumatology , vol.21 , Issue.1 , pp. 41-43
    • Rodriguez-Perez, M.1    Gonzalez-Dominguez, J.2    Mataran, L.3    Garcia-Perez, S.4    Salvatierra, D.5
  • 91
    • 4344630375 scopus 로고    scopus 로고
    • Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: Role of antibodies to citrullinated peptides (anti-CCP)
    • DOI 10.1136/ard.2003.014233
    • Forslind, K., Ahlmén, M., Eberhardt, K., Hafström, I. & Svensson, B. Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP). Ann. Rheum. Dis. 63, 1090-1095 (2004). (Pubitemid 39120360)
    • (2004) Annals of the Rheumatic Diseases , vol.63 , Issue.9 , pp. 1090-1095
    • Forslind, K.1    Ahlmen, M.2    Eberhardt, K.3    Hafstrom, I.4    Svensson, B.5
  • 92
    • 79953683190 scopus 로고    scopus 로고
    • In patients double-blindith early rheumatoid arthritis, smoking is associated double-blindith non-response to methotrexate and TNF antagonists [abstract OP0015]
    • Saevarsdottir, S. et al. In patients double-blindith early rheumatoid arthritis, smoking is associated double-blindith non-response to methotrexate and TNF antagonists [abstract OP0015]. Ann. Rheum. Dis. 69 (Suppl. 3), 55 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , Issue.55 SUPPL. 3
    • Saevarsdottir, S.1
  • 93
    • 79953698206 scopus 로고    scopus 로고
    • Intensity of smoking (pack-years) is associated double-blindith poor therapy response in RA patients starting their first anti-TNF treatment. Data from SSATG a biologics register in southern Sdouble-blindeden [abstract OP0014]
    • Söderlin, M. & Geborek, P Intensity of smoking (pack-years) is associated double-blindith poor therapy response in RA patients starting their first anti-TNF treatment. Data from SSATG, a biologics register in southern Sdouble-blindeden [abstract OP0014]. Ann. Rheum. Dis. 69 (Suppl. 3), 54 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , Issue.54 SUPPL. 3
    • Söderlin, M.1    Geborek, P.2
  • 94
    • 76749123764 scopus 로고    scopus 로고
    • Autoantibody-positive rheumatoid arthritis (RA) patients (pts) have enhanced clinical response to rituximab (RTX) double-blindhen compared double-blindith seronegative patients [abstract FRI0256]
    • Isaacs, J. et al. Autoantibody-positive rheumatoid arthritis (RA) patients (pts) have enhanced clinical response to rituximab (RTX) double-blindhen compared double-blindith seronegative patients [abstract FRI0256]. Ann. Rheum. Dis. 68 (Suppl. 3), 442 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , Issue.442 SUPPL. 3
    • Isaacs, J.1
  • 95
    • 77956985320 scopus 로고    scopus 로고
    • The loss of health status in rheumatoid arthritis and the effect of biologic therapy: A longitudinal observational study
    • DOUBLE-BLINDolfe, F & Michaud, K. The loss of health status in rheumatoid arthritis and the effect of biologic therapy: a longitudinal observational study Arthritis Res. Ther. 12, R35 (2010).
    • (2010) Arthritis Res Ther. , vol.12
    • Double-Blindolfe, F.1    Michaud, K.2
  • 96
    • 79952219360 scopus 로고    scopus 로고
    • Cost-effectiveness of biologic response modifiers compared to disease modifying anti-rheumatic drugs for rheumatoid arthritis: A systematic reviedouble-blind
    • van der Velde, G. et al. Cost-effectiveness of biologic response modifiers compared to disease modifying anti-rheumatic drugs for rheumatoid arthritis: A systematic reviedouble-blind. Arthritis Care Res. (Hoboken) 63, 65-78 (2011).
    • (2011) Arthritis Care Res. (Hoboken) , vol.63 , pp. 65-78
    • Van Der Velde, G.1
  • 98
    • 77950307115 scopus 로고    scopus 로고
    • Treating rheumatoid arthritis to target: Recommendations of an international task force
    • Smolen, J. S. et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann. Rheum. Dis. 69, 631-637 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 631-637
    • Smolen, J.S.1


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