Highly efficient racemisation of a key intermediate of the antibiotic moxifloxacin

Tetrahedron Asymmetry

Volumn 22, Issue 4, 2011, Pages 379-380

  Pallavicini, Marco ^a   Bolchi, Cristiano ^a   Fumagalli, Laura ^a   Piccolo, Oreste ^b   Valoti, Ermanno ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Studio di Consulenza Scientifica   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 BENZYL 7,9 DIOXO 2,8 DIAZABICYCLO[4.3.0]NONANE; MOXIFLOXACIN; UNCLASSIFIED DRUG;

ARTICLE; CHLORINATION; DEHYDROGENATION; HYDROGENATION; PRIORITY JOURNAL; RACEMIC MIXTURE; RACEMIZATION;

EID: 79953714232     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/j.tetasy.2011.02.007     Document Type: Article

References (6)

1. DE 3906365 A1, 1990.
2. US Patent 6566523, 2003.
3. US Patent 6392044, 2002.
4. M. Pallavicini, C. Bolchi, L. Fumagalli, O. Piccolo, and E. Valoti Tetrahedron Lett. 51 2010 5540 5542
5. Obtained by resolution of rac-cis-1 according to Ref. 2.
6. 2: C, 68.83; H, 6.60; N, 11.47. Found: C, 68.64; H, 6.68; N, 11.41