Explaining sex difference in coronary heart disease: Is it time to shift from the oestrogen hypothesis to the iron hypothesis?

Journal of Cardiovascular Medicine

Volumn 12, Issue 1, 2011, Pages 64-65

  Mascitelli, Luca ^a   Goldstein, Mark R ^b   Pezzetta, Francesca ^c  

^a Medical Service ^*  (Italy)

^b Fountain Medical Court ^*  (United States)

^c Ospedale Civile di Tolmezzo   (Italy)

Author keywords

Coronary heart disease; Iron; Menopause; Oestrogens

Indexed keywords

ESTROGEN; FERROPORTIN; HEPCIDIN; IRON;

ATHEROSCLEROSIS; FEMALE; FERTILE PERIOD; HEMOCHROMATOSIS; HORMONE BLOOD LEVEL; HUMAN; IRON BLOOD LEVEL; IRON DEPLETION; IRON METABOLISM; IRON STORAGE; ISCHEMIC HEART DISEASE; MALE; MENOPAUSE; OVARY FUNCTION; POSTMENOPAUSE; REVIEW; SEX DIFFERENCE;

CORONARY DISEASE; ESTROGENS; FEMALE; HUMANS; IRON, DIETARY; MALE; POSTMENOPAUSE; PRIMARY OVARIAN INSUFFICIENCY; RISK FACTORS; SEX FACTORS;

EID: 79953706285     PISSN: 15582027     EISSN: None     Source Type: Journal    
DOI: 10.2459/JCM.0b013e3283403942     Document Type: Review

References (17)

1. Mercuro G, Deidda M, Piras A, Dessalvi CC, Maffei S, Rosano GM. Gender determinants of cardiovascular risk factors and diseases. J Cardiovasc Med 2010; 11:207-220.
2. Casiglia E, Tikhonoff V, Caffi S, Bascelli A, Schiavon L, Guidotti F, et al. Menopause does not affect blood pressure and risk profile, and menopausal women do not become similar to men. J Hypertens 2008; 26:1983-1992.
3. Kannel WB, Levy D. Menopause, hormones, and cardiovascular vulnerability in women. Arch Intern Med 2004; 164:479-481. (Pubitemid 38314441)
4. Mascitelli L, Sullivan JL, Pezzetta F, Goldstein MR. Iron and cardiovascular risk in menopause. J Hypertens 2009; 27:438-439.
5. Sullivan JL. Iron and the sex difference in heart disease risk. Lancet 1981; 1:1293-1294. (Pubitemid 11111356)
6. Sullivan JL, Mascitelli L. Current status of the iron hypothesis of cardiovascular diseases. Recenti Prog Med 2007; 98:373-377. (Pubitemid 46982784)
7. Sullivan JL. Macrophage iron, hepcidin, and atherosclerotic plaque stability. Exp Biol Med (Maywood) 2007; 232:1014-1020. (Pubitemid 47358184)
8. Sullivan JL. Do hemochromatosis mutations protect against iron-mediated atherogenesis? Circ Cardiovasc Genet 2009; 2:652-657.
9. Sowers JR. Diabetes mellitus and cardiovascular disease in women. Arch Intern Med 1998; 158:617-621. (Pubitemid 28144819)
10. Manzi S. Systemic lupus erythematosus: a model for atherogenesis? Rheumatology 2000; 39:353-359.
11. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB. The role of iron in type 2 diabetes in humans. Biochim Biophys Acta 2009; 1790:671-681.
12. Mascitelli L, Pezzetta F, Goldstein MR. Hyperinsulinaemia and iron perturbation in patients with type 2 diabetes. Int J Clin Pract 2009; 63:672.
13. Brown AC. Lupus erythematosus and nutrition: a review of the literature. J Ren Nutr 2000; 10:170-183.
14. Mascitelli L, Pezzetta F, Sullivan JL. Iron, hepcidin, and increased atherosclerosis in systemic lupus erythematosus. Int J Cardiol 2008; 131:e20-e21.
15. Tan YY, Gast GC, van der Schouw YT. Gender differences in risk factors for coronary heart disease. Maturitas 2010; 65:149-160.
16. Mascitelli L, Pezzetta F, Goldstein MR. Body iron stores and gender differences in risk factors for coronary heart disease. Maturitas 2010; 66:107.
17. Mascitelli L, Pezzetta F. Cardiovascular protections in severely impaired hemostasis. Circulation 2004; 110:e39.