Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion

Behavioural Brain Research

Volumn 222, Issue 1, 2011, Pages 1-9

  Hsieh, Tsung Hsun ^a   Chen, Jia Jin J ^a   Chen, Li Hsien ^b   Chiang, Pei Tzu ^c   Lee, Hsiao Yu ^c  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c FAR EAST UNIVERSITY   (Taiwan)

Author keywords

6 OHDA; Dopaminergic neurons; Gait pattern; Parkinson's disease

Indexed keywords

APOMORPHINE; DOPAMINE; OXIDOPAMINE;

ADULT ANIMAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FOREBRAIN; GAIT; GAIT DISORDER; HINDLIMB; MALE; MOTOR PERFORMANCE; NEUROLOGIC EXAMINATION; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RAT; WALKING SPEED;

ANALYSIS OF VARIANCE; ANIMALS; APOMORPHINE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FUNCTIONAL LATERALITY; GAIT DISORDERS, NEUROLOGIC; MALE; MEDIAL FOREBRAIN BUNDLE; MOVEMENT; OXIDOPAMINE; PARKINSONIAN DISORDERS; PSYCHOMOTOR PERFORMANCE; RATS; RATS, WISTAR; STEREOTYPED BEHAVIOR; SYMPATHOLYTICS; TIME FACTORS; TYROSINE 3-MONOOXYGENASE; VIDEOTAPE RECORDING;

EID: 79953704200     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.03.031     Document Type: Article

References (46)

1. Bjorklund A., Dunnett S.B. Dopamine neuron systems in the brain: an update. Trends Neurosci 2007, 30:194-202.
2. Giladi N., Treves T.A., Simon E.S., Shabtai H., Orlov Y., Kandinov B., et al. Freezing of gait in patients with advanced Parkinson's disease. J Neural Transm 2001, 108:53-61.
3. Chee R., Murphy A., Danoudis M., Georgiou-Karistianis N., Iansek R. Gait freezing in Parkinson's disease and the stride length sequence effect interaction. Brain 2009, 132:2151-2160.
4. Nieuwboer A., Dom R., De Weerdt W., Desloovere K., Fieuws S., Broens-Kaucsik E. Abnormalities of the spatiotemporal characteristics of gait at the onset of freezing in Parkinson's disease. Mov Disord 2001, 16:1066-1075.
5. Blin O., Ferrandez A.M., Serratrice G. Quantitative analysis of gait in Parkinson patients: increased variability of stride length. J Neurol Sci 1990, 98:91-97.
6. Truong L., Allbutt H., Kassiou M., Henderson J.M. Developing a preclinical model of Parkinson's disease: a study of behaviour in rats with graded 6-OHDA lesions. Behav Brain Res 2006, 169:1-9.
7. Deumens R., Blokland A., Prickaerts J. Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Exp Neurol 2002, 175:303-317.
8. Mabrouk O.S., Marti M., Salvadori S., Morari M. The novel delta opioid receptor agonist UFP-512 dually modulates motor activity in hemiparkinsonian rats via control of the nigro-thalamic pathway. Neuroscience 2009, 164:360-369.
9. Fantin M., Auberson Y.P., Morari M. Differential effect of NR2A and NR2B subunit selective NMDA receptor antagonists on striato-pallidal neurons: relationship to motor response in the 6-hydroxydopamine model of parkinsonism. J Neurochem 2008, 106:957-968.
10. Lindner M.D., Plone M.A., Francis J.M., Blaney T.J., Salamone J.D., Emerich D.F. Rats with partial striatal dopamine depletions exhibit robust and long-lasting behavioral deficits in a simple fixed-ratio bar-pressing task. Behav Brain Res 1997, 86:25-40.
11. Lindner M.D., Plone M.A., Francis J.M., Emerich D.F. Validation of a rodent model of Parkinson's disease: evidence of a therapeutic window for oral Sinemet. Brain Res Bull 1996, 39:367-372.
12. Metz G.A., Tse A., Ballermann M., Smith L.K., Fouad K. The unilateral 6-OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis. Eur J Neurosci 2005, 22:735-744.
13. Amende I., Kale A., McCue S., Glazier S., Morgan J.P., Hampton T.G. Gait dynamics in mouse models of Parkinson's disease and Huntington's disease. J Neuroeng Rehabil 2005, 2:20.
14. Chang J.Y., Shi L.H., Luo F., Woodward D.J. Neural responses in multiple basal ganglia regions following unilateral dopamine depletion in behaving rats performing a treadmill locomotion task. Exp Brain Res 2006, 172:193-207.
15. Klein A., Wessolleck J., Papazoglou A., Metz G.A., Nikkhah G. Walking pattern analysis after unilateral 6-OHDA lesion and transplantation of foetal dopaminergic progenitor cells in rats. Behav Brain Res 2009, 199:317-325.
16. Vlamings R., Visser-Vandewalle V., Koopmans G., Joosten E.A., Kozan R., Kaplan S., et al. High frequency stimulation of the subthalamic nucleus improves speed of locomotion but impairs forelimb movement in Parkinsonian rats. Neuroscience 2007, 148:815-823.
17. Chaniary K.D., Baron M.S., Rice A.C., Wetzel P.A., Ramakrishnan V., Shapiro S.M. Quantification of gait in dystonic Gunn rats. J Neurosci Methods 2009, 180:273-277.
18. Yu P., Matloub H.S., Sanger J.R., Narini P. Gait analysis in rats with peripheral nerve injury. Muscle Nerve 2001, 24:231-239.
19. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 2005, Elsevier Academic Press, Amsterdam. 5th ed.
20. Mabrouk O.S., Volta M., Marti M., Morari M. Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism. J Neurochem 2008, 107:1647-1659.
21. Fischer D.A., Ferger B., Kuschinsky K. Discrimination of morphine- and haloperidol-induced muscular rigidity and akinesia/catalepsy in simple tests in rats. Behav Brain Res 2002, 134:317-321.
22. Paille V., Henry V., Lescaudron L., Brachet P., Damier P. Rat model of Parkinson's disease with bilateral motor abnormalities, reversible with levodopa, and dyskinesias. Mov Disord 2007, 22:533-539.
23. Blandini F., Levandis G., Bazzini E., Nappi G., Armentero M.T. Time-course of nigrostriatal damage, basal ganglia metabolic changes and behavioural alterations following intrastriatal injection of 6-hydroxydopamine in the rat: new clues from an old model. Eur J Neurosci 2007, 25:397-405.
24. Yoon M.C., Shin M.S., Kim T.S., Kim B.K., Ko I.G., Sung Y.H., et al. Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats. Neurosci Lett 2007, 423:12-17.
25. Fearnley J.M., Lees A.J. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991, 114(Pt 5):2283-2301.
26. Muir G.D., Whishaw I.Q. Ground reaction forces in locomoting hemi-parkinsonian rats: a definitive test for impairments and compensations. Exp Brain Res 1999, 126:307-314.
27. Olsson M., Nikkhah G., Bentlage C., Bjorklund A. Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 1995, 15:3863-3875.
28. Miklyaeva E.I., Martens D.J., Whishaw I.Q. Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats. Brain Res 1995, 681:23-40.
29. Hausdorff J.M., Cudkowicz M.E., Firtion R., Wei J.Y., Goldberger A.L. Gait variability and basal ganglia disorders: stride-to-stride variations of gait cycle timing in Parkinson's disease and Huntington's disease. Mov Disord 1998, 13:428-437.
30. Wang Y., Bontempi B., Hong S.M., Mehta K., Weinstein P.R., Abrams G.M., et al. A comprehensive analysis of gait impairment after experimental stroke and the therapeutic effect of environmental enrichment in rats. J Cereb Blood Flow Metab 2008, 28:1936-1950.
31. Marin C., Aguilar E., Mengod G., Cortes R., Obeso J.A. Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats. Eur J Neurosci 2009, 30:823-832.
32. Hefti F., Melamed E., Sahakian B.J., Wurtman R.J. Circling behavior in rats with partial, unilateral nigro-striatal lesions: effect of amphetamine, apomorphine, and DOPA. Pharmacol Biochem Behav 1980, 12:185-188.
33. Hudson J.L., van Horne C.G., Stromberg I., Brock S., Clayton J., Masserano J., et al. Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats. Brain Res 1993, 626:167-174.
34. Steiner H., Kitai S.T. Unilateral striatal dopamine depletion: time-dependent effects on cortical function and behavioural correlates. Eur J Neurosci 2001, 14:1390-1404.
35. Schallert T., Fleming S.M., Leasure J.L., Tillerson J.L., Bland S.T. CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology 2000, 39:777-787.
36. Schneider J.S., Peacock V. Differential effects of GDNF treatment on rotational asymmetry, skilled forelimb use deficits and sensory neglect in unilateral 6-OHDA-lesioned rats. Restor Neurol Neurosci 1998, 13:205-212.
37. Prentice S.D., Drew T. Contributions of the reticulospinal system to the postural adjustments occurring during voluntary gait modifications. J Neurophysiol 2001, 85:679-698.
38. Ferraye M.U., Debu B., Fraix V., Goetz L., Ardouin C., Yelnik J., et al. Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease. Brain 2010, 133:205-214.
39. Rauch F., Schwabe K., Krauss J.K. Effect of deep brain stimulation in the pedunculopontine nucleus on motor function in the rat 6-hydroxydopamine Parkinson model. Behav Brain Res 2010, 210:46-53.
40. Nandi D., Liu X., Winter J.L., Aziz T.Z., Stein J.F. Deep brain stimulation of the pedunculopontine region in the normal non-human primate. J Clin Neurosci 2002, 9:170-174.
41. Stefani A., Lozano A.M., Peppe A., Stanzione P., Galati S., Tropepi D., et al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain 2007, 130:1596-1607.
42. Breit S., Bouali-Benazzouz R., Benabid A.L., Benazzouz A. Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal activity of the pedunculopontine nucleus, which is reversed by the lesion of the subthalamic nucleus in the rat. Eur J Neurosci 2001, 14:1833-1842.
43. Florio T., Scarnati E., Confalone G., Minchella D., Galati S., Stanzione P., et al. High-frequency stimulation of the subthalamic nucleus modulates the activity of pedunculopontine neurons through direct activation of excitatory fibres as well as through indirect activation of inhibitory pallidal fibres in the rat. Eur J Neurosci 2007, 25:1174-1186.
44. Elahi B., Chen R. Effect of transcranial magnetic stimulation on Parkinson motor function-systematic review of controlled clinical trials. Mov. Disord. 2009, 24:357-363.
45. Fang J.H., Chen J.J.J., Hwang I.H., Huang Y.Z. Review: repetitive transcranial magnetic stimulation over the human primary motor cortex for modulating motor control and motor learning. J. Med. Biol. Eng. 2010, 30:193-201.
46. Chang Y.J., Hsieh T.H., Huang Y.M., Hsu M.J., Wong A.M. A lack of modulation of motor evoked potential in sensory-impaired individuals with spinal cord injuries. J. Med. Biol. Eng. 2011, 31:37-43.