Inverse agonist-like action of cadmium on G-protein-gated inward-rectifier K+ channels

Biochemical and Biophysical Research Communications

Volumn 407, Issue 2, 2011, Pages 366-371

  Inanobe, Atsushi ^a   Matsuura, Takanori ^a   Nakagawa, Atsushi ^a   Kurachi, Yoshihisa ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Allosteric regulation; Crystallography; Electrophysiology; G protein; Inward rectifier K+ channel

Indexed keywords

CADMIUM; CYSTEINE; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CHANNEL GATING; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; CYTOPLASM; ELECTROPHYSIOLOGY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; REGULATORY MECHANISM;

ANIMALS; CADMIUM; CYSTEINE; CYTOPLASM; DRUG INVERSE AGONISM; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MICE; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SWINE; X-RAY DIFFRACTION;

EID: 79953697068     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.03.025     Document Type: Article

References (35)

1. MacKinnon R. Potassium channels. FEBS Lett. 2003, 555:62-65.
2. Hibino H., Inanobe A., Furutani K., Murakami S., Findlay I., Kurachi Y. Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol. Rev. 2010, 90:291-366.
3. Aschcroft F.M. Inward rectifying K+ channels. Ion Channels Dis. 2000, 135-159.
4. Nishida M., MacKinnon R. Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8Å resolution. Cell 2002, 111:957-965.
5. Kuo A., Gulbis J.M., Antcliff J.F., Rahman T., Lowe E.D., Zimmer J., Cuthbertson J., Ashcroft F.M., Ezaki T., Doyle D.A. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science 2003, 300:1922-1926.
6. Bichet D., Haass F.A., Jan L.Y. Merging functional studies with structures of inward-rectifier K+ channels. Nat. Rev. Neurosci. 2003, 4:957-967.
7. Logothetis D.E., Lupyan D., Rosenhouse-Dantsker A. Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding. J. Physiol. 2007, 582:953-965.
8. Kuo A., Domene C., Johnson L.N., Doyle D.A., Venien-Bryan C. Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography. Structure 2005, 13:1463-1472.
9. Jaroslawski S., Zadek B., Ashcroft F., Venien-Bryan C., Scheuring S. Direct visualization of KirBac3.1 potassium channel gating by atomic force microscopy. J. Mol. Biol. 2007, 374:500-505.
10. Clarke O.B., Caputo A.T., Hill A.P., Vandenberg J.I., Smith B.J., Gulbis J.M. Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels. Cell 2010, 141:1018-1029.
11. Inanobe A., Nakagawa A., Matsuura T., Kurachi Y. A structural determinant for the control of PIP2 sensitivity in G protein-gated inward rectifier K+ channels. J. Biol. Chem. 2010, 285:38517-38523.
12. Yokogawa M., Osawa M., Takeuchi K., Mase Y., Shimada I. NMR analyses of the Gbetagamma binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 (GIRK1). J. Biol. Chem. 2011, 286:2215-2223.
13. Inanobe A., Horio Y., Fujita A., Tanemoto M., Hibino H., Inageda K., Kurachi Y. Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis. J. Physiol. 1999, 521:19-30.
14. Sui J.L., Chan K.W., Logothetis D.E. Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism. J. Gen. Physiol. 1996, 108:381-391.
15. Huang C.L., Feng S., Hilgemann D.W. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ. Nature 1998, 391:803-806.
16. Goldstein D.A. Calculation of the concentrations of free cations and cation-ligand complexes in solutions containing multiple divalent cations and ligands. Biophys. J. 1979, 26:235-242.
17. Inanobe A., Matsuura T., Nakagawa A., Kurachi Y. Structural diversity in the cytoplasmic region of G protein-gated inward rectifier K+ channels. Channels 2007, 1:39-45.
18. Otwinowski Z., Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 1997, 276:307-326.
19. N.Collaborative Computational Project The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 1994, 50:760-763.
20. Emsley P., Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 2004, 60:2126-2132.
21. Ho I.H., Murrell-Lagnado R.D. Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels. J. Physiol. 1999, 520(Pt 3):645-651.
22. Pegan S., Arrabit C., Zhou W., Kwiatkowski W., Collins A., Slesinger P.A., Choe S. Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat. Neurosci. 2005, 8:279-287.
23. Nishida M., Cadene M., Chait B.T., MacKinnon R. Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J. 2007, 26:4005-4015.
24. Gupta S., Bavro V.N., D'Mello R., Tucker S.J., Venien-Bryan C., Chance M.R. Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry. Structure 2010, 18:839-846.
25. Schulte U., Hahn H., Konrad M., Jeck N., Derst C., Wild K., Weidemann S., Ruppersberg J.P., Fakler B., Ludwig J. PH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome. Proc. Natl. Acad. Sci. USA 1999, 96:15298-15303.
26. Yorifuji T., Nagashima K., Kurokawa K., Kawai M., Oishi M., Akazawa Y., Hosokawa M., Yamada Y., Inagaki N., Nakahata T. The C42R mutation in the Kir6.2 (KCNJ11) gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 2005, 90:3174-3178.
27. Schulte U., Hahn H., Wiesinger H., Ruppersberg J.P., Fakler B. PH-dependent gating of ROMK (Kir1.1) channels involves conformational changes in both N and C termini. J. Biol. Chem. 1998, 273:34575-34579.
28. Trapp S., Tucker S.J., Ashcroft F.M. Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification. J. Gen. Physiol. 1998, 112:325-332.
29. Lu T., Nguyen B., Zhang X., Yang J. Architecture of a K+ channel inner pore revealed by stoichiometric covalent modification. Neuron 1999, 22:571-580.
30. Loussouarn G., Makhina E.N., Rose T., Nichols C.G. Structure and dynamics of the pore of inwardly rectifying KATP channels. J. Biol. Chem. 2000, 275:1137-1144.
31. Guo Y., Waldron G.J., Murrell-Lagnado R. A role for the middle C terminus of G-protein-activated inward rectifier potassium channels in regulating gating. J. Biol. Chem. 2002, 277:48289-48294.
32. Zeidner G., Sadja R., Reuveny E. Redox-dependent gating of G protein-coupled inwardly rectifying K+ channels. J. Biol. Chem. 2001, 276:35564-35570.
33. Hevers W., Luddens H. The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes. Mol. Neurobiol. 1998, 18:35-86.
34. Oldham W.M., Van Eps N., Preininger A.M., Hubbell W.L., Hamm H.E. Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nat. Struct. Mol. Biol. 2006, 13:772-777.
35. Nagy L., Schwabe J.W. Mechanism of the nuclear receptor molecular switch. Trends Biochem. Sci. 2004, 29:317-324.