Hyaluronic acid-based hydrogels crosslinked by copper-catalyzed azide-alkyne cycloaddition with tailorable mechanical properties

International Journal of Artificial Organs

Volumn 34, Issue 2, 2011, Pages 192-197

  Piluso, Susanna ^a,b   Hiebl, Bernhard ^a   Gorb, Stanislav N ^c   Kovalev, Alexander ^c   Lendlein, Andreas ^a,b   Neffe, Axel T ^a,b  

^a INSTITUTE OF MATERIALS RESEARCH   (Germany)

^b UNIVERSITY OF POTSDAM   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Biomaterial; Hyaluronic acid; Hydrogel; Microindentation; Rheology

Indexed keywords

BIOCOMPATIBILITY; BIOMECHANICS; BIOPOLYMERS; CATALYSIS; CELL CULTURE; COPPER COMPOUNDS; CROSSLINKING; HYDROCARBONS; HYDROGELS; MEDICAL APPLICATIONS; ORGANIC ACIDS; TISSUE REGENERATION; TOXIC MATERIALS;

CLICK CHEMISTRY; COPPER CATALYZED AZIDE ALKYNE CYCLOADDITION; CROSSLINKED; CROSSLINKER; EXTRACELLULAR MATRICES; FUNCTIONALIZED; LINKER MOLECULES; MICRO INDENTATION; TUNABLES; TWO TERMINALS;

HYALURONIC ACID;

ALKYNE; AZIDE; BIOMATERIAL; COPPER; DIAZIDOSTILBENE; HYALURONIC ACID; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL CULTURE; CLICK CHEMISTRY; CONTROLLED STUDY; CROSS LINKING; CYCLOADDITION; CYTOTOXICITY; DENSITY; DRY WEIGHT; ELUTION; GEL; HYDROGEL; MECHANICS; MOUSE; NONHUMAN; SOFT TISSUE REGENERATION; TISSUE REGENERATION; YOUNG MODULUS;

EID: 79953693009     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.5301/IJAO.2011.6394     Document Type: Article

References (16)

1. Rickert D, Scheithauer MO, Coskun S, Kelch S, Lendlein A, Franke RP. The influence of a multifunctional, polymeric biomaterial on the concentration of acute phase proteins in an animal model. Clin Hemorheol Microcirc 2007; 36 (4): 301-11.
2. Shastri VP, Lendlein A. Materials in regenerative medicine. Adv Mater 2009; 21 (32-33): 3231-4.
3. Toole BP. Hyaluronan in morphogenesis. J Intern Med 1997; 242 (1): 35-40.
4. Malavaki CJ, Kanakis I, Theocharis AD, Lamari FN, Karamanos NK. Hyaluronan determination: Biological significance & analytical tools. Curr Pharm Anal 2007; 3 (2): 117-28.
5. Shu XZ, Liu Y, Luo Y, Roberts MC, Prestwich GD. Disulfidecrosslinked hyaluronan hydrogels. Biomacromolecules 2002; 3 (6): 1304-11.
6. Ramamurthi A, Vesely I. Smooth muscle cell adhesion on crosslinked hyaluronan gels. J Biomed Mater Res 2002; 60 (1): 195-205.
7. Kolb H, Finn MG, Sharpless KB. Click chemistry: Diverse chemical function from a few good reactions. Angew Chem Int Ed 2001; 40 (11): 2004-21.
8. Gribbon P, Heng BC, Hardingham TE. The molecular basis of the solution properties of hyaluronan investigated by confocal fluorescence recovery after photobleaching. Biophys J 1999; 77 (4): 2210-6.
9. Lendlein A, Zotzmann J, Feng Y, Alteheld A, Kelch S. Controlling the Switching Temperature of Biodegradable, Amorphous, Shape-Memory Poly(rac-lactide)urethane Networks by Incorporation of Different Comonomers. Biomacromolecules 2009; 10 (4): 975-82.
10. Choi NY, Lendlein A. Degradable shape-memory polymer networks from oligo[(L-lactide)-ran-glycolide]dimethacrylates. Soft Matter 2007; 3 (7): 901-9.
11. Tronci G, Neffe AT, Pierce B, Lendlein A. An Entropy-Elastic gelatin-based hydrogel system. J Mater Chem 2010; 20: 8875-84.
12. Crescenzi V, Cornelio L, Di Meo C, Nardecchia S, Lamanna R. Novel Hydrogels via Click Chemistry: Synthesis and Potential Biomedical Applications. Biomacromolecules 2007; 8: 1844-50.
13. Gorb S, Jiao Y, Scherge M. Ultrastractural architecture and mechanical properties of attachment pads in Tettigonia viridissima (Orthoptera Tettigoniidae). J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2000; 186: 821-31.
14. Johnson K, Kendall K, Roberts AD. Surface energy and the contact of elastic solids. Proc R Soc Lond A Math Phys Sci 1971; 324: 301-13.
15. Vogel S. Life's devices. The physical world of animals and plants. Princeton, New Jersey: Princeton University Press; 1988.
16. Solon J, Levental I, Sengputa K, Georges PC, Jamney PA. Fibroblast Adaptation and Stiffness Matching to Elastic Substrates. Biophys J 2007; 93 (12): 4453-61.