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Volumn 133, Issue 14, 2011, Pages 5170-5173

A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY-BASED; ANALYTES; DIAGNOSTIC ASSAYS; SIGNAL AMPLIFICATIONS; SMALL MOLECULE SYSTEMS; SMALL MOLECULES; THRESHOLD LEVELS; TWO-COMPONENT; VISUAL DETECTION;

EID: 79953690843     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja108347d     Document Type: Article
Times cited : (110)

References (30)
  • 18
    • 79953680596 scopus 로고    scopus 로고
    • This solvent system was chosen after a screen of other solvents. Reagent 1 is not soluble in pure water, and therefore, we explored mixtures of water and MeCN, DMF, DMSO, MeOH, and THF. We chose the combination of solvents that gave the fastest signal amplification reaction. The relative order of reactivity was MeOH > DMSO > DMF > MeCN > THF. We included pyridine as a precaution to buffer any HF that might develop during the signal amplification process.
    • This solvent system was chosen after a screen of other solvents. Reagent 1 is not soluble in pure water, and therefore, we explored mixtures of water and MeCN, DMF, DMSO, MeOH, and THF. We chose the combination of solvents that gave the fastest signal amplification reaction. The relative order of reactivity was MeOH > DMSO > DMF > MeCN > THF. We included pyridine as a precaution to buffer any HF that might develop during the signal amplification process.
  • 22
    • 79953714103 scopus 로고    scopus 로고
    • Silyl ethers are known to hydrolyze slowly in water; therefore, it remains a possibility that the background signal obtained with reagent 1 may be the consequence of a slow hydrolysis reaction followed by autocatalytic amplification of the released fluoride.
    • Silyl ethers are known to hydrolyze slowly in water; therefore, it remains a possibility that the background signal obtained with reagent 1 may be the consequence of a slow hydrolysis reaction followed by autocatalytic amplification of the released fluoride.
  • 30
    • 79953679086 scopus 로고    scopus 로고
    • After 6 h, enough fluoride was present to provide an efficient amplification process in the second step. See the SI for details.
    • After 6 h, enough fluoride was present to provide an efficient amplification process in the second step. See the SI for details.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.