Elevated expression of cancer-associated proliferating cell nuclear antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer

Prostate

Volumn 71, Issue 7, 2011, Pages 748-754

  Wang, Xiaoyan ^a   Hickey, Robert J ^a   Malkas, Linda H ^a   Koch, Michael O ^a   Li, Lang ^a   Zhang, Shaobo ^a   Sandusky, George E ^a   Grignon, David J ^a   Eble, John N ^a   Cheng, Liang ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biomarkers; Carcinogenesis; Gleason grading; High grade prostatic intraepithelial neoplasia (PIN); Neoplasia; Progression; Proliferating cell nuclear antigen (PCNA); Prostate; Targeted therapy

Indexed keywords

CANCER ASSOCIATED PROLIFERATING CELL NUCLEAR ANTIGEN; CYCLINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INVASION; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE EPITHELIUM; PROSTATECTOMY; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN EXPRESSION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROSTATECTOMY; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; PROTEIN ISOFORMS; TUMOR MARKERS, BIOLOGICAL;

EID: 79953689580     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.21291     Document Type: Article

References (21)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009;59(4):225-249.
2. Hoelz DJ, Arnold RJ, Dobrolecki LE, Abdel-Aziz W, Loehrer AP, Novotny MV, Schnaper L, Hickey RJ, Malkas LH. The discovery of labile methyl esters on proliferating cell nuclear antigen by MS/MS. Proteomics 2006;6(17):4808-4816. (Pubitemid 44369060)
3. Yang J, Chen Z, Liu Y, Hickey RJ, Malkas LH. Altered DNA polymerase iota expression in breast cancer cells leads to a reduction in DNA replication fidelity and a higher rate of mutagenesis. Cancer Res 2004;64(16):5597-5607. (Pubitemid 39095555)
4. Sekowski JW, Malkas LH, Schnaper L, Bechtel PE, Long BJ, Hickey RJ. Human breast cancer cells contain an error-prone DNA replication apparatus. Cancer Res 1998;58(15):3259-3263. (Pubitemid 28371062)
5. Stoimenov I, Helleday T. PCNA on the crossroad of cancer. Biochem Soc Trans 2009;37(Pt 3):605-613.
6. Miyamoto S, Ito K, Kurokawa K, Suzuki K, Yamanaka H. Clinical validity of proliferating cell nuclear antigen as an objective marker for evaluating biologic features in patients with untreated prostate cancer. Int J Urol 2006;13(6):767-772. (Pubitemid 43926770)
7. Mayer A, Takimoto M, Fritz E, Schellander G, Kofler K, Ludwig H. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer 1993;71(8):2454-2460. (Pubitemid 23100476)
8. Morell-Quadreny L, Clar-Blanch F, Fenollosa-Enterna B, Perez- Bacete M, Martinez-Lorente A, Llombart-Bosch A. Proliferating cell nuclear antigen (PCNA) as a prognostic factor in renal cell carcinoma. Anticancer Res 1998;18(1B):677-682.
9. Guzinska-Ustymowicz K, Pryczynicz A, Kemona A, Czyzewska J. Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer. Anticancer Res 2009;29(8):3049-3052.
10. Bechtel PE, Hickey RJ, Schnaper L, Sekowski JW, Long BJ, Freund R, Liu N, Rodriguez-Valenzuela C, Malkas LH.Aunique form of proliferating cell nuclear antigen is present in malignant breast cells. Cancer Res 1998;58(15):3264-3269. (Pubitemid 28371063)
11. Malkas LH, Herbert BS, Abdel-Aziz W, Dobrolecki LE, Liu Y, Agarwal B, Hoelz D, Badve S, Schnaper L, Arnold RJ, Mechref Y, Novotny MV, Loehrer P, Goulet RJ, Hickey RJ. A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker. Proc Natl Acad Sci USA 2006;103(51):19472-19477. (Pubitemid 46026055)
12. Cheng L, Pan C, Zhang JT, Zhang S, Kinch MS, Li L, Baldridge LA, Wade C, Hu Z, Koch MO, Ulbright TM, Eble JN. Loss of 14-3- 3sigma in prostate cancer and its precursors. Clin Cancer Res 2004;10:3064-3068. (Pubitemid 38619684)
13. Jiang J, Neubauer BL, Graff JR, Chedid M, Thomas JE, Roehm NW, Zhang S, Eckert GJ, Koch MO, Eble JN, Cheng L. Expression of group IIA secretory phospholipase A2 is elevated in prostatic intraepithelial neoplasia and adenocarcinoma. Am J Pathol 2002;160:667-671. (Pubitemid 34160344)
14. Pan CX, Kinch MS, Kiener PA, Langermann S, Serrero G, Sun L, Corvera J, Sweeney CJ, Li L, Zhang S, Baldridge LA, Jones TD, Koch MO, Ulbright TM, Eble JN, Cheng L. PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma. Clin Cancer Res 2004;10:1333-1337. (Pubitemid 38365225)
15. Rao VV, Schnittger S, Hansmann I. Chromosomal localization of the human proliferating cell nuclear antigen (PCNA) gene to or close to 20p12 by in situ hybridization. Cytogenet Cell Genet 1991;56(3-4):169-170.
16. Travali S, Ku DH, Rizzo MG, Ottavio L, Baserga R, Calabretta B. Structure of the human gene for the proliferating cell nuclear antigen. J Biol Chem 1989;264(13):7466-7472. (Pubitemid 19119161)
17. Naryzhny SN. Proliferating cell nuclear antigen: A proteomics view. Cell Mol Life Sci 2008;65(23):3789-3808.
18. Taftachi R, Ayhan A, Ekici S, Ergen A, Ozen H. Proliferating-cell nuclear antigen (PCNA) as an independent prognostic marker in patients after prostatectomy: A comparison of PCNA and Ki-67. BJU Int 2005;95(4):650-654. (Pubitemid 40311491)
19. Naryzhny SN, Lee H. The post-translational modifications of proliferating cell nuclear antigen: Acetylation, not phosphorylation, plays an important role in the regulation of its function. J Biol Chem 2004;279(19):20194-20199. (Pubitemid 38623464)
20. Venturi A, Piaz FD, Giovannini C, Gramantieri L, Chieco P, Bolondi L. Human hepatocellular carcinoma expresses specific PCNA isoforms: An in vivo and in vitro evaluation. Lab Invest 2008;88(9):995-1007.
21. Hammoud ZT, Badve S, Saxena R, Kesler KA, Rieger K, Malkas LH, Hickey RJ. A novel biomarker for the detection of esophageal adenocarcinoma. J Thorac Cardiovasc Surg 2007;133(1):82-87. (Pubitemid 46014209)