Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers

Toxicology and Applied Pharmacology

Volumn 252, Issue 2, 2011, Pages 112-122

  Matheis, Katja A ^a   Com, Emmanuelle ^b,c   Gautier, Jean Charles ^b   Guerreiro, Nelson ^d   Brandenburg, Arnd ^e   Gmuender, Hans ^e   Sposny, Alexandra ^f   Hewitt, Philip ^f   Amberg, Alexander ^g   Boernsen, Olaf ^d   Riefke, Bjoern ^h   Hoffmann, Dana ^j   Mally, Angela ^j   Kalkuhl, Arno ^a   Suter, Laura ⁱ   Dieterle, Frank ^d   Staedtler, Frank ^d  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b SANOFI   (France)

^c Parc Scientifique de Luminy   (France)

^d NOVARTIS PHARMA AG   (Switzerland)

^e GENEDATA AG   (Switzerland)

^f MERCK KGAA   (Germany)

^g SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^h BAYER PHARMA AG   (Germany)

ⁱ F HOFFMANN LA ROCHE LTD   (Switzerland)

^j UNIVERSITY OF WÜRZBURG   (Germany)

more..

Author keywords

2D DIGE; Complement system; CORO1A; Microarray; Osteoactivin; Proximal tubule damage; Rat kidney

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; BI 3; BIOLOGICAL MARKER; CALBINDIN; CATALASE; CERULOPLASMIN; CLU PROTEIN; CLUSTERIN; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4A; COMPLEMENT COMPONENT C5A RECEPTOR; CYCLOSPORIN A [8 DEXTRO O (2 HYDROXYETHYL)SERINE]; GENTAMICIN; GLUTATHIONE PEROXIDASE 1; HEAT SHOCK TRANSCRIPTION FACTOR 1; INTERCELLULAR ADHESION MOLECULE 1; KIM 1 PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; METHIONINE SULFOXIDE REDUCTASE A; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUROFILAMENT M PROTEIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OSTEOPONTIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (PYROPHOSPHATE); TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEMENT SYSTEM; GENE EXPRESSION; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MALE; MICROARRAY ANALYSIS; NONHUMAN; PROTEOMICS; RAT; TRANSCRIPTOMICS;

ANIMALS; BIOLOGICAL MARKERS; CYCLOSPORINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENETIC MARKERS; GENTAMICINS; KIDNEY TUBULES, PROXIMAL; MALE; PROTEOMICS; RATS; RATS, WISTAR;

ANIMALIA; RATTUS;

EID: 79953685509     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.11.006     Document Type: Article

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