Genetic polymorphisms in DNA double-strand break repair genes XRCC5, XRCC6 and susceptibility to hepatocellular carcinoma

Carcinogenesis

Volumn 32, Issue 4, 2011, Pages 530-536

  Li, Rui ^a   Yang, Yuan ^b,c   An, Yu ^a   Zhou, Yun ^c   Liu, Yanhong ^a,d   Yu, Qing ^e   Lu, Daru ^a   Wang, Hongyang ^c   Jin, Li ^a   Zhou, Weiping ^b   Qian, Ji ^a   Shugart, Yin Yao ^f  

^a FUDAN UNIVERSITY   (China)

^b EASTERN HEPATOBILIARY SURGERY HOSPITAL   (China)

^c Eastern Institute of Hepatobiliary Surgery   (China)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e WENZHOU MEDICAL UNIVERSITY   (China)

^f NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; HEPATITIS B SURFACE ANTIGEN;

ADULT; ARTICLE; CANCER RISK; CHINESE; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FEMALE; GENE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HEPATITIS B; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; XRCC5 GENE; XRCC6 GENE;

ADULT; AGED; ANTIGENS, NUCLEAR; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; DNA HELICASES; DNA-BINDING PROTEINS; EPISTASIS, GENETIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79953673876     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr018     Document Type: Article

References (52)

1. Pang,R.W. et al. (2007) From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now. Oncology, 72 (suppl. 1), 30-44.
2. El-Serag,H.B. et al. (2003) The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann. Intern. Med., 139, 817-823.
3. Bruix,J. et al. (2004) Focus on hepatocellular carcinoma. Cancer Cell, 5, 215-219.
4. Trevisani,F. et al. (2008) Recent advances in the natural history of hepatocellular carcinoma. Carcinogenesis, 29, 1299-1305.
5. El-Serag,H.B. et al. (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557-2576.
6. Bosch,F.X. et al. (2004) Primary liver cancer: worldwide incidence and trends. Gastroenterology, 127, S5-S16.
7. Farazi,P.A. et al. (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer., 6, 674-687.
8. Calvisi,D.F. et al. (2004) Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice. Gastroenterology, 126, 1374-1386.
9. Khanna,K.K. et al. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet., 27, 247-254.
10. van Gent,D.C. et al. (2001) Chromosomal stability and the DNA doublestranded break connection. Nat. Rev. Genet., 2, 196-206.
11. Tong,W.M. et al. (2002) Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Res., 62, 6990-6996.
12. Teoh,N.C. et al. (2008) Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice. Hepatology, 47, 2078-2088.
13. Hironaka,K. et al. (2003) Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis. Lab Invest., 83, 643-654.
14. Barash,H. et al. (2010) Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proc. Natl Acad. Sci. USA., 107, 2207-2212.
15. Seimiya,M. et al. (2008) Identification of novel immunohistochemical tumor markers for primary hepatocellular carcinoma; clathrin heavy chain and formiminotransferase cyclodeaminase. Hepatology, 48, 519-530.
16. Luk,J.M. et al. (2005) Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma. Proteomics, 5, 1980-1986.
17. Rothkamm,K. et al. (2003) Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell. Biol., 23, 5706-5715.
18. West,S.C. (2003) Molecular views of recombination proteins and their control. Nat. Rev. Mol. Cell. Biol., 4, 435-445.
19. d'Adda di Fagagna,F. et al. (2001) Effects of DNA nonhomologous endjoining factors on telomere length and chromosomal stability in mammalian cells. Curr. Biol., 11, 1192-1196.
20. Hsu,H.L. et al. (2000) Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev., 14, 2807-2812.
21. Kuschel,B. et al. (2002) Variants in DNA double-strand break repair genes and breast cancer susceptibility. Hum. Mol. Genet., 11, 1399-1407.
22. Fu,Y.P. et al. (2003) Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility. Cancer Res., 63, 2440-2446.
23. Lee,K.M. et al. (2005) Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk. Clin. Cancer Res., 11, 4620-4626.
24. Liu,Y. et al. (2007) Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma. Carcinogenesis, 28, 1906-1913.
25. Danoy,P. et al. (2008) Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers. Int. J. Cancer., 123, 457-463.
26. Wu,X. et al. (2006) Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. Am. J. Hum. Genet., 78, 464-479.
27. Tseng,R.C. et al. (2009) Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: a multiple genotype-phenotype study. Cancer, 115, 2939-2948.
28. Michiels,S. et al. (2009) Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Carcinogenesis, 30, 763-768.
29. Bau,D.T. et al. (2008) Oral cancer and genetic polymorphism of DNA double strand break gene Ku70 in Taiwan. Oral Oncol., 44, 1047-1051.
30. Ryder,S.D. (2003) Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut, 52 (suppl. 3), iii1-iii8.
31. Barrett,J.C. et al. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics, 21, 263-265.
32. Carlson,C.S. et al. (2004) Selecting a maximally informative set of singlenucleotide polymorphisms for association analyses using linkage disequilibrium. Am. J. Hum. Genet., 74, 106-120.
33. Schaid,D.J. et al. (2002) Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am. J. Hum. Genet., 70, 425-434.
34. Stephens,M. et al. (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am. J. Hum. Genet., 73, 1162-1169.
35. Ritchie,M.D. et al. (2001) Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am. J. Hum. Genet., 69, 138-147.
36. Moore,J.H. et al. (2002) New strategies for identifying gene-gene interactions in hypertension. Ann. Med., 34, 88-95.
37. Ochem,A.E. et al. (1997) Functional properties of the separate subunits of human DNA helicase II/Ku autoantigen. J. Biol. Chem., 272, 29919-29926.
38. Li,H. et al. (2009) Deleting Ku70 is milder than deleting Ku80 in p53-mutant mice and cells. Oncogene, 28, 1875-1878.
39. Muguruma,M. et al. (2006) Molecular pathological analysis for determining the possible mechanism of piperonyl butoxide-induced hepatocarcinogenesis in mice. Toxicology, 228, 178-187.
40. Reliene,R. et al. (2006) Developmental cell death in the liver and newborn lethality of Ku86 deficientmice suppressed by antioxidant N-acetyl-cysteine. DNA Repair (Amst), 5, 1392-1397.
41. Liu,E.S. et al. (1991) Common sets of nuclear factors binding to the conserved promoter sequence motif of two coordinately regulated ER protein genes, GRP78 and GRP94. Nucleic Acids Res., 19, 5425-5431.
42. Shuda,M. et al. (2003) Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J. Hepatol., 38, 605-614.
43. Zhu,X. et al. (2009) Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: risk and prognosis. Int. J. Cancer., 125, 1352-1357.
44. Myung,K. et al. (2004) Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86. Mol. Cell. Biol., 24, 5050-5059.
45. Wang,Y. et al. (2009) Ku86 represses lethal telomere deletion events in human somatic cells. Proc. Natl Acad. Sci. USA., 106, 12430-12435.
46. Yuan,H.Y. et al. (2006) FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res., 34, W635-W641.
47. Willems,P. et al. (2008) Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity. Genes Chromosomes Cancer, 47, 137-148.
48. Brechot,C. et al. (2000) Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Semin. Cancer Biol., 10, 211-231.
49. Paterlini-Brechot,P. et al. (2003) Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene, 22, 3911-3916.
50. Murakami,Y. et al. (2005) Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut, 54, 1162-1168.
51. Yang,W. et al. (1995) Illegitimate replication of linear hepadnavirus DNA through nonhomologous recombination. J. Virol., 69, 4029-4036.
52. Bill,C.A. et al. (2004) Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration. Proc. Natl Acad. Sci. USA., 101, 11135-11140.