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Volumn 1, Issue 5, 2010, Pages 651-665

Personalized medicine: The impact on chemistry

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); THIOPURINE METHYLTRANSFERASE;

EID: 79953668817     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.10.64     Document Type: Review
Times cited : (10)

References (133)
  • 1
    • 75149194970 scopus 로고    scopus 로고
    • Progress towards personalized medicine
    • Bates S. Progress towards personalized medicine. Drug Discov. Today 15(3-4), 115-120 (2010).
    • (2010) Drug Discov. Today , vol.15 , Issue.3-4 , pp. 115-120
    • Bates, S.1
  • 2
    • 0032707829 scopus 로고    scopus 로고
    • New era of personalized medicine: Targeting drugs for each unique genetic profile
    • Langreth R, Waldholz M. New era of personalized medicine: targeting drugs for each unique genetic profile. Oncologist 4(5), 426-427 (1999). (Pubitemid 29508743)
    • (1999) Oncologist , vol.4 , Issue.5 , pp. 426-427
    • Langreth, R.1    Waldholz, M.2
  • 4
    • 8444252965 scopus 로고    scopus 로고
    • Genomic and proteomic technologies for individualisation and improvement of cancer treatment
    • DOI 10.1016/j.ejca.2004.05.020, PII S0959804904005015
    • Wulfkuhle J, Espina V, Liotta L, Petricoin E. Genomic and proteomic technologies for individualisation and improvement of cancer treatment. Eur. J. Cancer 40(17), 2623-2632 (2004). (Pubitemid 39487084)
    • (2004) European Journal of Cancer , vol.40 , Issue.17 SPEC. ISS. , pp. 2623-2632
    • Wulfkuhle, J.1    Espina, V.2    Liotta, L.3    Petricoin, E.4
  • 5
    • 77951589703 scopus 로고    scopus 로고
    • Clinical assessment incorporating a personal genome
    • Ashley EA, Butte AJ, Wheeler MT, et al. Clinical assessment incorporating a personal genome. Lancet 375(9725), 1525-1535 (2010).
    • (2010) Lancet , vol.375 , Issue.9725 , pp. 1525-1535
    • Ashley, E.A.1    Butte, A.J.2    Wheeler, M.T.3
  • 6
    • 34250718607 scopus 로고    scopus 로고
    • Foundations, promises and uncertainties of personalized medicine
    • DOI 10.1002/msj.20005
    • Bottinger EP. Foundations, promises and uncertainties of personalized medicine. Mount Sinai J. Med. 74(1), 15-21 (2007). (Pubitemid 46957751)
    • (2007) Mount Sinai Journal of Medicine , vol.74 , Issue.1 , pp. 15-21
    • Bottinger, E.P.1
  • 7
    • 27744463332 scopus 로고    scopus 로고
    • Pharmacogenetics/genomics and personalized medicine
    • DOI 10.1093/hmg/ddi261
    • Sadee W, Dai Z. Pharmacogenetics/genomics and personalized medicine. Hum. Mol. Genet. 14(Spec No. 2), R207-R214 (2005). (Pubitemid 41631889)
    • (2005) Human Molecular Genetics , vol.14 , Issue.SUPPL. 2
    • Sadee, W.1    Dai, Z.2
  • 8
    • 0034619028 scopus 로고    scopus 로고
    • Adverse drug reactions: Definitions, diagnosis, and management
    • Edwards Ir, Aronson Jk. Adverse drug reactions: definitions, diagnosis, and management. Lancet 356(9237), 1255-1259 (2000).
    • (2000) Lancet , vol.356 , Issue.9237 , pp. 1255-1259
    • Ir, E.1    Aronson, Jk.2
  • 9
    • 34347374925 scopus 로고    scopus 로고
    • Raju Kucherlapati talks about personalised medicine: Breathing new life into old drugs
    • Kucherlapati R. Raju Kucherlapati talks about personalised medicine: breathing new life into old drugs. Interview by Steve Carney. Drug Discov. Today 12(7-8), 272-275 (2007).
    • (2007) Interview by Steve Carney. Drug Discov. Today , vol.12 , Issue.7-8 , pp. 272-275
    • Kucherlapati, R.1
  • 12
    • 77954926600 scopus 로고    scopus 로고
    • Pharmacogenetics and personalized medicine: The future for drug prescribing
    • Mitri Z, Esmerian MO, Simaan JA, Sabra R, Zgheib NK. Pharmacogenetics and personalized medicine: the future for drug prescribing. J. Med. Liban. 58(2), 101-104 (2010).
    • (2010) J. Med. Liban. , vol.58 , Issue.2 , pp. 101-104
    • Mitri, Z.1    Esmerian, M.O.2    Simaan, J.A.3    Sabra, R.4    Zgheib, N.K.5
  • 13
    • 0017695082 scopus 로고
    • Polymorphic hydroxylation of debrisoquine in man
    • Mahgoub A, Idle JR, Dring LG, Lancaster R, Smith RL. Polymorphic hydroxylation of debrisoquine in man. Lancet 2(8038), 584-586 (1977). (Pubitemid 8176607)
    • (1977) Lancet , vol.2 , Issue.8038 , pp. 584-586
    • Mahgoub, A.1    Idle, J.R.2    Dring, L.G.3
  • 14
    • 0028954786 scopus 로고
    • Robust nonradioactive oligonucleotide ligation assay to detect a common point mutation in the cyp 2d6 gene causing abnormal drug metabolism
    • Hansen T, Petersen N, Iitia A, Blaabjerg O, Hyltoft-Petersen P, Horder M. Robust nonradioactive oligonucleotide ligation assay to detect a common point mutation in the cyp 2d6 gene causing abnormal drug metabolism. Clin. Chem. 41(3), 413-418 (1995).
    • (1995) Clin. Chem. , vol.41 , Issue.3 , pp. 413-418
    • Hansen, T.1    Petersen, N.2    Iitia, A.3    Blaabjerg, O.4    Hyltoft-Petersen, P.5    Horder, M.6
  • 15
    • 14844360833 scopus 로고    scopus 로고
    • Influence of cyp 2d6 genetics on opioid kinetics, metabolism and response
    • Gerd M, Johanna W. Influence of cyp 2d6 genetics on opioid kinetics, metabolism and response. Curr. Pharmacogenomics 3, 43-52 (2005).
    • (2005) Curr. Pharmacogenomics , vol.3 , pp. 43-52
    • Gerd, M.1    Johanna, W.2
  • 16
    • 13544249943 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity
    • DOI 10.1038/sj.tpj.6500285
    • Ingelman-Sundberg M. Genetic polymorphisms of cytochrome p450 2d6 (cyp 2d6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J. 5(1), 6-13 (2004). (Pubitemid 40220611)
    • (2005) Pharmacogenomics Journal , vol.5 , Issue.1 , pp. 6-13
    • Ingelman-Sundberg, M.1
  • 17
    • 45849107951 scopus 로고    scopus 로고
    • Clinical pharmacology and pharmacogenetics of thiopurines
    • Sahasranaman S, Howard D, Roy S. Clinical pharmacology and pharmacogenetics of thiopurines. Eur. J. Clin. Pharmacol. 64(8), 753-767 (2008).
    • (2008) Eur. J. Clin. Pharmacol. , vol.64 , Issue.8 , pp. 753-767
    • Sahasranaman, S.1    Howard, D.2    Roy, S.3
  • 18
    • 0029073930 scopus 로고
    • Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine s-methyltransferase
    • Krynetski EY, Krynetskaia NF, Yanishevski Y, Evans WE. Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine s-methyltransferase. Mol. Pharmacol. 47(6), 1141-1147 (1995).
    • (1995) Mol. Pharmacol. , vol.47 , Issue.6 , pp. 1141-1147
    • Krynetski, E.Y.1    Krynetskaia, N.F.2    Yanishevski, Y.3    Evans, W.E.4
  • 20
    • 77950387206 scopus 로고    scopus 로고
    • Thiopurine s-methyltransferase (tpmt ) assessment prior to starting thiopurine drug treatment; A pharmacogenomic test whose time has come
    • Ford LT, Berg JD. Thiopurine s-methyltransferase (tpmt ) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come. J. Clin. Pathol. 63(4), 288-295 (2010).
    • (2010) J. Clin. Pathol. , vol.63 , Issue.4 , pp. 288-295
    • Ford, L.T.1    Berg, J.D.2
  • 23
    • 65949104586 scopus 로고    scopus 로고
    • Genomewide association studies and human disease
    • Hardy J, Singleton A. Genomewide association studies and human disease. N. Engl. J. Med. 360(17), 1759-1768 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.17 , pp. 1759-1768
    • Hardy, J.1    Singleton, A.2
  • 24
    • 58349115384 scopus 로고    scopus 로고
    • Screening for replication of genome-wide snp associations in sporadic als
    • Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O. Screening for replication of genome-wide snp associations in sporadic als . Eur. J. Hum. Genet. 17(2), 213-218 (2008).
    • (2008) Eur. J. Hum. Genet. , vol.17 , Issue.2 , pp. 213-218
    • Cronin, S.1    Tomik, B.2    Bradley, D.G.3    Slowik, A.4    Hardiman, O.5
  • 25
    • 13144265739 scopus 로고    scopus 로고
    • Genome-wide association studies: Theoretical and practical concerns
    • DOI 10.1038/nrg1522
    • Wang WYS, Barratt BJ, Clayton DG, Todd JA. Genome-wide association studies: theoretical and practical concerns. Nat. Rev. Genet. 6(2), 109-118 (2005). (Pubitemid 40179533)
    • (2005) Nature Reviews Genetics , vol.6 , Issue.2 , pp. 109-118
    • Wang, W.Y.S.1    Barratt, B.J.2    Clayton, D.G.3    Todd, J.A.4
  • 27
    • 68249128647 scopus 로고    scopus 로고
    • Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome
    • Yang L, Chen J, He L. Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome. PLoS Comput. Biol. 5(7), e1000441 (2009).
    • (2009) PLoS Comput. Biol. , vol.5 , Issue.7
    • Yang, L.1    Chen, J.2    He, L.3
  • 28
    • 67849110009 scopus 로고    scopus 로고
    • Sepresa: A server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical-protein interactome
    • Yang L, Luo H, Chen J, Xing Q, He L. Sepresa: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical-protein interactome. Nucleic Acids Res. 37(Suppl. 2), W406-412 (2009).
    • (2009) Nucleic Acids Res. , vol.37 , Issue.SUPPL. 2
    • Yang, L.1    Luo, H.2    Chen, J.3    Xing, Q.4    He, L.5
  • 30
    • 34147162376 scopus 로고    scopus 로고
    • Pharmacogenetics of warfarin: Current status and future challenges
    • Wadelius M, Pirmohamed M. Pharmacogenetics of warfarin: current status and future challenges. Pharmacogenomics J. 7(2), 99-111 (2006).
    • (2006) Pharmacogenomics J. , vol.7 , Issue.2 , pp. 99-111
    • Wadelius, M.1    Pirmohamed, M.2
  • 31
    • 0034283762 scopus 로고    scopus 로고
    • Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment
    • Taube J, Halsall D, Baglin T. Influence of cytochrome p-450 cyp 2c9 polymorphisms on warfarin sensitivity and risk of overanticoagulation in patients on long-term treatment. Blood 96(5), 1816-1819 (2000). (Pubitemid 30661066)
    • (2000) Blood , vol.96 , Issue.5 , pp. 1816-1819
    • Taube, J.1    Halsall, D.2    Baglin, T.3
  • 33
    • 23044440450 scopus 로고    scopus 로고
    • The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: Proposal for a new dosing regimen
    • DOI 10.1182/blood-2005-03-1108
    • Sconce EA, Khan TI, Wynne HA, et al. The impact of cyp 2c9 and vkorc1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen. Blood 106(7), 2329-2333 (2005). (Pubitemid 41510803)
    • (2005) Blood , vol.106 , Issue.7 , pp. 2329-2333
    • Sconce, E.A.1    Khan, T.I.2    Wynne, H.A.3    Avery, P.4    Monkhouse, L.5    King, B.P.6    Wood, P.7    Kesteven, P.8    Daly, A.K.9    Kamali, F.10
  • 34
    • 34247141066 scopus 로고    scopus 로고
    • Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1 - Rationale and perspectives
    • DOI 10.1016/j.thromres.2006.10.021, PII S0049384806004373
    • Yin T, Miyata T. Warfarin dose and the pharmacogenomics of cyp 2c9 and vkorc1 - rationale and perspectives. Thromb. Res. 120(1), 1-10 (2007). (Pubitemid 46601582)
    • (2007) Thrombosis Research , vol.120 , Issue.1 , pp. 1-10
    • Yin, T.1    Miyata, T.2
  • 35
    • 0024316072 scopus 로고
    • Major bleeding in outpatients treated with warfarin: Incidence and prediction by factors known at the start of outpatient therapy
    • Landefeld CS, Ohio Lee G. Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy. Am. J. Med. 87(2), 144-152 (1989). (Pubitemid 19201634)
    • (1989) American Journal of Medicine , vol.87 , Issue.2 , pp. 144-152
    • Landefeld, C.S.1    Goldman, L.2
  • 37
    • 0035892035 scopus 로고    scopus 로고
    • A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke
    • Mohr JP, Thompson JLP, Lazar RM, et al. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N. Engl. J. Med. 345(20), 1444-1451 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , Issue.20 , pp. 1444-1451
    • Mohr, J.P.1    Jlp, T.2    Lazar, R.M.3
  • 39
    • 60849097257 scopus 로고    scopus 로고
    • Estimation of the warfarin dose with clinical and pharmacogenetic data
    • Klein TE, Altman RB, Eriksson N, et al. Estimation of the warfarin dose with clinical and pharmacogenetic data. N. Engl. J. Med. 360(8), 753-764 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.8 , pp. 753-764
    • Klein, T.E.1    Altman, R.B.2    Eriksson, N.3
  • 41
    • 13644260557 scopus 로고    scopus 로고
    • Enhanced antithrombotic effect of warfarin associated with low-dose alcohol consumption
    • DOI 10.1592/phco.25.2.303.56955
    • Havrda DE, Mai T, Chonlahan J. Enhanced antithrombotic effect of warfarin associated with low-dose alcohol consumption. Pharmacotherapy 25(2), 303-307 (2005). (Pubitemid 40227466)
    • (2005) Pharmacotherapy , vol.25 , Issue.2 , pp. 303-307
    • Havrda, D.E.1    Mai, T.2    Chonlahan, J.3
  • 42
    • 0036785307 scopus 로고    scopus 로고
    • Revisiting the significance of warfarin protein-binding displacement interactions
    • Sands CD, Chan ES, Welty TE. Revisiting the significance of warfarin protein-binding displacement interactions. Ann. Pharmacother. 36(10), 1642-1644 (2002).
    • (2002) Ann. Pharmacother. , vol.36 , Issue.10 , pp. 1642-1644
    • Sands, C.D.1    Chan, E.S.2    Welty, T.E.3
  • 43
    • 77951498679 scopus 로고    scopus 로고
    • Integration of genetic, clinical, and inr data to refine warfarin dosing
    • Lenzini P, Wadelius M, Kimmel S, et al. Integration of genetic, clinical, and inr data to refine warfarin dosing. Clin. Pharmacol. Ther. 87(5), 572-578 (2010).
    • (2010) Clin. Pharmacol. Ther. , vol.87 , Issue.5 , pp. 572-578
    • Lenzini, P.1    Wadelius, M.2    Kimmel, S.3
  • 44
    • 0033608466 scopus 로고    scopus 로고
    • Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
    • DOI 10.1016/S0140-6736(98)04474-2
    • Aithal GP, Day CP, Kesteven PJL, Daly AK. Association of polymorphisms in the cytochrome P450 cyp 2c9 with warfarin dose requirement and risk of bleeding complications. Lancet 353(9154), 717-719 (1999). (Pubitemid 29103806)
    • (1999) Lancet , vol.353 , Issue.9154 , pp. 717-719
    • Aithal, G.P.1    Day, C.P.2    Kesteven, P.J.L.3    Daly, A.K.4
  • 45
    • 0036433035 scopus 로고    scopus 로고
    • Pharmacogenetics and personalised medicine
    • DOI 10.1046/j.1472-8206.2002.00109.x
    • Kalow W. Pharmacogenetics and personalised medicine. Fundamen. Clin. Pharmacol. 16(5), 337-342 (2002). (Pubitemid 35356942)
    • (2002) Fundamental and Clinical Pharmacology , vol.16 , Issue.5 , pp. 337-342
    • Kalow, W.1
  • 46
    • 70449525348 scopus 로고    scopus 로고
    • Study on the intermolecular interactions in rifampicin ternary solutions - Calculation of microscopic parameters of rifampicin molecules
    • Nadejde C, Creanga DE, Humelnicu I, Filip E, Dorohoi DO. Study on the intermolecular interactions in rifampicin ternary solutions - calculation of microscopic parameters of rifampicin molecules. J. Mol. Liq. 150(1-3), 51-55 (2009).
    • (2009) J. Mol. Liq. , vol.150 , Issue.1-3 , pp. 51-55
    • Nadejde, C.1    Creanga, D.E.2    Humelnicu, I.3    Filip, E.4    Dorohoi, D.O.5
  • 47
    • 0035201366 scopus 로고    scopus 로고
    • Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: Studies with cDNA and oligonucleotide expression arrays
    • Rae JM, Johnson MD, Lippman ME, Flockhart DA. Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cdna and oligonucleotide expression arrays. J. Pharmacol. Exp. Ther. 299(3), 849-857 (2001). (Pubitemid 33104951)
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.299 , Issue.3 , pp. 849-857
    • Rae, J.M.1    Johnson, M.D.2    Lippman, M.E.3    Flockhart, D.A.4
  • 48
    • 0018931869 scopus 로고
    • Dose: A critical factor in cancer chemotherapy
    • Emil F, George PC. Dose: a critical factor in cancer chemotherapy. Am. J. Med. 69(4), 585-594 (1980).
    • (1980) Am. J. Med. , vol.69 , Issue.4 , pp. 585-594
    • Emil, F.1    George, P.C.2
  • 49
    • 0034740735 scopus 로고    scopus 로고
    • Chromogenic in situ hybridization analysis of her -2/neu status in breast carcinoma: Application in screening of patients for trastuzumab (Herceptin®) therapy
    • Kumamoto H, Sasano H, Taniguchi T, Suzuki T, Moriya T, Ichinohasama R. Chromogenic in situ hybridization analysis of her -2/neu status in breast carcinoma: application in screening of patients for trastuzumab (Herceptin®) therapy. Path. Int. 51(8), 579-584 (2001).
    • (2001) Path. Int. , vol.51 , Issue.8 , pp. 579-584
    • Kumamoto, H.1    Sasano, H.2    Taniguchi, T.3    Suzuki, T.4    Moriya, T.5    Ichinohasama, R.6
  • 50
    • 0035037366 scopus 로고    scopus 로고
    • Molecular targets for breast cancer therapy and prevention
    • DOI 10.1038/87872
    • Bange J, Zwick E, Ullrich A. Molecular targets for breast cancer therapy and prevention. Nat. Med. 7(5), 548-552 (2001). (Pubitemid 32448320)
    • (2001) Nature Medicine , vol.7 , Issue.5 , pp. 548-552
    • Bange, J.1    Zwick, E.2    Ullrich, A.3
  • 51
    • 70749108747 scopus 로고    scopus 로고
    • Comparison of immunohistochemistry (ihc ) and fluorescence in situ hybridization (fish ) assessment for her-2 status in breast cancer
    • Sui W, Ou M, Chen J, et al. Comparison of immunohistochemistry (ihc ) and fluorescence in situ hybridization (fish ) assessment for her-2 status in breast cancer. World J. Surg. Onc. 7(1), 83 (2009).
    • (2009) World J. Surg. Onc. , vol.7 , Issue.1 , pp. 83
    • Sui, W.1    Ou, M.2    Chen, J.3
  • 52
    • 54249085844 scopus 로고    scopus 로고
    • Chemical biology and the limits of reductionism
    • Peterson RT. Chemical biology and the limits of reductionism. Nat. Chem. Biol. 4(11), 635-638 (2008).
    • (2008) Nat. Chem. Biol. , vol.4 , Issue.11 , pp. 635-638
    • Peterson, R.T.1
  • 53
    • 0025103363 scopus 로고
    • The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater
    • Buzzi MG, Moskowitz MA. The antimigraine drug, sumatriptan (gr 43175), selectively blocks neurogenic plasma extravasation from blood vessels in Dura Mater. Br. J. Pharmacol. 99(1), 202-206 (1990). (Pubitemid 20033811)
    • (1990) British Journal of Pharmacology , vol.99 , Issue.1 , pp. 202-206
    • Buzzi, M.G.1    Moskowitz, M.A.2
  • 55
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: The next paradigm in drug discovery
    • Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol. 4(11), 682-690 (2008).
    • (2008) Nat. Chem. Biol. , vol.4 , Issue.11 , pp. 682-690
    • Hopkins, A.L.1
  • 56
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness
    • DOI 10.1038/nrg1471
    • Kitano H. Biological robustness. Nat. Rev. Genet. 5(11), 826-837 (2004). (Pubitemid 39457498)
    • (2004) Nature Reviews Genetics , vol.5 , Issue.11 , pp. 826-837
    • Kitano, H.1
  • 57
    • 33846574259 scopus 로고    scopus 로고
    • Fragments, network biology and designing multiple ligands
    • DOI 10.1016/j.drudis.2006.12.006, PII S1359644606004892
    • Morphy R, Rankovic Z. Fragments, network biology and designing multiple ligands. Drug Discov. Today 12(3-4), 156-160 (2007). (Pubitemid 46176667)
    • (2007) Drug Discovery Today , vol.12 , Issue.3-4 , pp. 156-160
    • Morphy, R.1    Rankovic, Z.2
  • 58
    • 27144443099 scopus 로고    scopus 로고
    • Drug discovery: Playing dirty
    • Frantz S. Drug discovery: playing dirty. Nature 437(7061), 942-943 (2005).
    • (2005) Nature , vol.437 , Issue.7061 , pp. 942-943
    • Frantz, S.1
  • 59
    • 33845762340 scopus 로고    scopus 로고
    • Multi-target therapeutics: When the whole is greater than the sum of the parts
    • DOI 10.1016/j.drudis.2006.11.008, PII S1359644606004697
    • Zimmermann GR, Lehar J, Keith CT. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov. Today 12(1-2), 34-42 (2007). (Pubitemid 46014485)
    • (2007) Drug Discovery Today , vol.12 , Issue.1-2 , pp. 34-42
    • Zimmermann, G.R.1    Lehar, J.2    Keith, C.T.3
  • 60
    • 35148824614 scopus 로고    scopus 로고
    • Network pharmacology
    • DOI 10.1038/nbt1007-1110, PII NBT10071110
    • Hopkins AL. Network pharmacology. Nat. Biotech. 25(10), 1110-1111 (2007). (Pubitemid 47538107)
    • (2007) Nature Biotechnology , vol.25 , Issue.10 , pp. 1110-1111
    • Hopkins, A.L.1
  • 61
    • 0033168957 scopus 로고    scopus 로고
    • Monogenic traits are not simple: Lessons from phenylketonuria
    • DOI 10.1016/S0168-9525(99)01761-8, PII S0168952599017618
    • Scriver CR, Waters PJ. Monogenic traits are not simple: lessons from phenylketonuria. Trends Genet. 15(7), 267-272 (1999). (Pubitemid 29317711)
    • (1999) Trends in Genetics , vol.15 , Issue.7 , pp. 267-272
    • Scriver, C.R.1    Waters, P.J.2
  • 62
    • 0033799531 scopus 로고    scopus 로고
    • Modifier genes convert 'simple' Mendelian disorders to complex traits
    • Dipple KM, Mccabe ERB. Modifier genes convert 'simple' Mendelian disorders to complex traits. Mol. Genet. Metab. 71(1-2), 43-50 (2000).
    • (2000) Mol. Genet. Metab. , vol.71 , Issue.1-2 , pp. 43-50
    • Dipple, K.M.1    McCabe, E.R.B.2
  • 64
    • 67149130229 scopus 로고    scopus 로고
    • Drug discovery. Repurposing with a difference
    • Boguski MS, Mandl KD, Sukhatme VP. Drug discovery. Repurposing with a difference. Science 324(5933), 1394-1395 (2009).
    • (2009) Science , vol.324 , Issue.5933 , pp. 1394-1395
    • Boguski, M.S.1    Mandl, K.D.2    Sukhatme, V.P.3
  • 65
    • 77649182705 scopus 로고    scopus 로고
    • Unveiling the role of network and systems biology in drug discovery
    • Pujol A, Mosca R, Farrés J, Aloy P. Unveiling the role of network and systems biology in drug discovery. Trends Pharmacol. Sci. 31(3), 115-123 (2010).
    • (2010) Trends Pharmacol. Sci. , vol.31 , Issue.3 , pp. 115-123
    • Pujol, A.1    Mosca, R.2    Farrés, J.3    Aloy, P.4
  • 66
    • 41149137043 scopus 로고    scopus 로고
    • Towards a molecular characterisation of pathological pathways
    • Pache RA, Zanzoni A, Naval J, Mas JM, Aloy P. Towards a molecular characterisation of pathological pathways. FEBS Lett 582(8), 1259-1265 (2008).
    • (2008) FEBS Lett , vol.582 , Issue.8 , pp. 1259-1265
    • Pache, R.A.1    Zanzoni, A.2    Naval, J.3    Mas, J.M.4    Aloy, P.5
  • 67
    • 38949179599 scopus 로고    scopus 로고
    • Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding
    • Leontiadis GI, Sreedharan A, Dorward S, et al. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding. Health Technol. Assess. 11(51), 1 (2007).
    • (2007) Health Technol. Assess. , vol.11 , Issue.51 , pp. 1
    • Leontiadis, G.I.1    Sreedharan, A.2    Dorward, S.3
  • 68
    • 77549083579 scopus 로고    scopus 로고
    • Dual coxib/tp antagonists: A possible new twist in nsaid pharmacology and cardiovascular risk
    • Rovati GE, Sala A, Capra V, Dahlèn S-E, Folco G. Dual coxib/tp antagonists: a possible new twist in nsaid pharmacology and cardiovascular risk. Trends Pharmacol. Sci. 31(3), 102-107 (2010).
    • (2010) Trends Pharmacol. Sci. , vol.31 , Issue.3 , pp. 102-107
    • Rovati, G.E.1    Sala, A.2    Capra, V.3    Dahlèn, S.-E.4    Folco, G.5
  • 69
    • 39149143293 scopus 로고    scopus 로고
    • A systems biology approach to prediction of oncogenes and molecular perturbation targets in b-cell lymphomas
    • Mani KM, Lefebvre C, Wang K, et al. A systems biology approach to prediction of oncogenes and molecular perturbation targets in b-cell lymphomas. Mol. Syst. Biol. 4, 169 (2008).
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 169
    • Mani, K.M.1    Lefebvre, C.2    Wang, K.3
  • 70
    • 69549109944 scopus 로고    scopus 로고
    • Conciliating binding efficiency and polypharmacology
    • Mestres J, Gregori-Puigjané E. Conciliating binding efficiency and polypharmacology. Trends Pharmacol. Sci. 30(9), 470-474 (2009).
    • (2009) Trends Pharmacol. Sci. , vol.30 , Issue.9 , pp. 470-474
    • Mestres, J.1    Gregori-Puigjané, E.2
  • 71
    • 70349914727 scopus 로고    scopus 로고
    • Pubchem as a source of polypharmacology
    • Chen B, Wild D, Guha R. Pubchem as a source of polypharmacology. J. Chem. Inf. Model. 49(9), 2044-2055 (2009).
    • (2009) J. Chem. Inf. Model. , vol.49 , Issue.9 , pp. 2044-2055
    • Chen, B.1    Wild, D.2    Guha, R.3
  • 74
    • 20644452017 scopus 로고    scopus 로고
    • Polypharmacy in the elderly: A literature review
    • Fulton MM, Allen ER. Polypharmacy in the elderly: a literature review. J. Am. Acad. Nurse Pract. 17(4), 123-132 (2005).
    • (2005) J. Am. Acad. Nurse Pract. , vol.17 , Issue.4 , pp. 123-132
    • Fulton, M.M.1    Allen, E.R.2
  • 75
    • 53249090182 scopus 로고    scopus 로고
    • Esc guidelines for the diagnosis and treatment of acute and chronic heart failure 2008
    • Dickstein K, Cohen-Solal A, Filippatos G, et al. Esc guidelines for the diagnosis and treatment of acute and chronic heart failure 2008. Eur. Heart J. 29(19), 2388-2442 (2008).
    • (2008) Eur. Heart J. , vol.29 , Issue.19 , pp. 2388-2442
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3
  • 77
    • 0038165393 scopus 로고    scopus 로고
    • A strategy to reduce cardiovascular disease by more than 80%
    • Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than 80%. BMJ 326(7404), 1419 (2003).
    • (2003) BMJ , vol.326 , Issue.7404 , pp. 1419
    • Wald, N.J.1    Law, M.R.2
  • 78
    • 33846435396 scopus 로고    scopus 로고
    • The preventive polypill - Much promise, insufficient evidence
    • Reddy Ks. The preventive polypill - much promise, insufficient evidence. N. Engl. J. Med. 356(3), 212 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , Issue.3 , pp. 212
    • Ks, R.1
  • 79
    • 72949101438 scopus 로고    scopus 로고
    • Structure and organization of drug-target networks: Insights from genomic approaches for drug discovery
    • Janga SC, Tzakos A. Structure and organization of drug-target networks: insights from genomic approaches for drug discovery. Mol. Biosyst. 5(12), 1536-1548 (2009).
    • (2009) Mol. Biosyst. , vol.5 , Issue.12 , pp. 1536-1548
    • Janga, S.C.1    Tzakos, A.2
  • 80
    • 0024809865 scopus 로고
    • Complex formation of c-myc papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
    • Munger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley Pm. Complex formation of human papillomavirus e7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8(13), 4099-4105 (1989). (Pubitemid 20066852)
    • (1989) EMBO Journal , vol.8 , Issue.13 , pp. 4099-4105
    • Munger, K.1    Werness, B.A.2    Dyson, N.3    Phelps, W.C.4    Harlow, E.5    Howley, P.M.6
  • 81
    • 5444266062 scopus 로고    scopus 로고
    • Racial/ethnic differences in hypertension and hypertension treatment and control in the Multi-Ethnic Study of Atherosclerosis (MESA)
    • DOI 10.1016/j.amjhyper.2004.06.001, PII S0895706104008611
    • Kramer H, Han C, Post W, et al. Racial/ethnic differences in hypertension and hypertension treatment and control in the multiethnic study of atherosclerosis (mesa ). Am. J. Hypertens. 17(10), 963-970 (2004). (Pubitemid 39361670)
    • (2004) American Journal of Hypertension , vol.17 , Issue.10 , pp. 963-970
    • Kramer, H.1    Han, C.2    Post, W.3    Goff, D.4    Diez-Roux, A.5    Cooper, R.6    Jinagouda, S.7    Shea, S.8
  • 82
    • 0035803699 scopus 로고    scopus 로고
    • Advanced drug delivery devices via self-assembly of amphiphilic block copolymers
    • DOI 10.1016/S0169-409X(01)00222-8, PII S0169409X01002228
    • Rösler A, Vandermeulen GWM, Klok H-A. Advanced drug delivery devices via selfassembly of amphiphilic block copolymers. Adv. Drug Deliv. Rev. 53(1), 95-108 (2001). (Pubitemid 33152835)
    • (2001) Advanced Drug Delivery Reviews , vol.53 , Issue.1 , pp. 95-108
    • Rosler, A.1    Vandermeulen, G.W.M.2    Klok, H.-A.3
  • 83
    • 0032875798 scopus 로고    scopus 로고
    • Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate)
    • DOI 10.1016/S0168-3659(99)00029-2, PII S0168365999000292
    • Chung JE, Yokoyama M, Yamato M, Aoyagi T, Sakurai Y, Okano T. Thermoresponsive drug delivery from polymeric micelles constructed using block copolymers of poly(n-isopropylacrylamide) and poly(butylmethacrylate). J. Control. Release 62(1-2), 115-127 (1999). (Pubitemid 29486490)
    • (1999) Journal of Controlled Release , vol.62 , Issue.1-2 , pp. 115-127
    • Chung, J.E.1    Yokoyama, M.2    Yamato, M.3    Aoyagi, T.4    Sakurai, Y.5    Okano, T.6
  • 85
    • 33749008790 scopus 로고    scopus 로고
    • Improving medication adherence: Challenges for physicians, payers, and policy makers
    • O'connor PJ. Improving medication adherence: challenges for physicians, payers, and policy makers. Arch. Intern. Med. 166(17), 1802-1804 (2006).
    • (2006) Arch. Intern. Med. , vol.166 , Issue.17 , pp. 1802-1804
    • O'Connor, P.J.1
  • 86
    • 0022472179 scopus 로고
    • Dose response and length of action of nifedipine capsules and tablets in patients with essential hypertension: A randomised crossover study
    • Cappuccio FP, Markandu ND, Tucker FA, Macgregor GA. Dose-response and length of action of nifedipine capsules and tablets in patients with essential-hypertension - a randomized crossover study. Eur. J. Clin. Pharmacol. 30(6), 723-725 (1986). (Pubitemid 16018954)
    • (1986) European Journal of Clinical Pharmacology , vol.30 , Issue.6 , pp. 723-725
    • Cappuccio, F.P.1    Markandu, N.D.2    Tucker, F.A.3    MacGregor, G.A.4
  • 87
    • 27744466964 scopus 로고    scopus 로고
    • Synthetic, self-assembly ABCD nanoparticles; a structural paradigm for viable synthetic non-viral vectors
    • DOI 10.1039/b307062j
    • Kostarelos K, Miller AD. Synthetic, selfassembly abcd nanoparticles; a structural paradigm for viable synthetic nonviral vectors. Chem. Soc. Rev. 34(11), 970-994 (2005). (Pubitemid 41619247)
    • (2005) Chemical Society Reviews , vol.34 , Issue.11 , pp. 970-994
    • Kostarelos, K.1    Miller, A.D.2
  • 88
    • 27144449695 scopus 로고    scopus 로고
    • Designed multiple ligands. An emerging drug discovery paradigm
    • DOI 10.1021/jm058225d
    • Morphy R, Rankovic Z. Designed multiple ligands. An emerging drug discovery paradigm. J. Med. Chem. 48(21), 6523-6543 (2005). (Pubitemid 41504710)
    • (2005) Journal of Medicinal Chemistry , vol.48 , Issue.21 , pp. 6523-6543
    • Morphy, R.1    Rankovic, Z.2
  • 89
    • 1942453243 scopus 로고    scopus 로고
    • Ligand efficiency: A useful metric for lead selection
    • DOI 10.1016/S1359-6446(04)03069-7, PII S1359644604030697
    • Hopkins AL, Groom CR, Alex A. Ligand efficiency: a useful metric for lead selection. Drug Discov. Today 9(10), 430-431 (2004). (Pubitemid 38510559)
    • (2004) Drug Discovery Today , vol.9 , Issue.10 , pp. 430-431
    • Hopkins, A.L.1    Groom, C.R.2    Alex, A.3
  • 90
    • 28944452691 scopus 로고    scopus 로고
    • From clinical research to clinical practice: A 4-year review of ziprasidone
    • Nemeroff CB, Lieberman JA, Weiden PJ, et al. From clinical research to clinical practice: a 4-year review of ziprasidone. CNS Spectr. 10(11) (Suppl. 17), 1-20 (2005).
    • (2005) CNS Spectr. , vol.10 , Issue.11 SUPPL. 17 , pp. 1-20
    • Nemeroff, C.B.1    Lieberman, J.A.2    Weiden, P.J.3
  • 91
    • 0028875303 scopus 로고
    • Ziprasidone (cp-88, 059): A new antipsychotic with combined dopamine and serotonin receptor antagonist activity
    • Seeger TF, Seymour PA, Schmidt AW, et al. Ziprasidone (cp-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J. Pharmacol. Exp. Ther. 275(1), 101-113 (1995).
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , Issue.1 , pp. 101-113
    • Seeger, T.F.1    Seymour, P.A.2    Schmidt, A.W.3
  • 92
    • 33644859466 scopus 로고    scopus 로고
    • Role of pharmacologically active metabolites in drug discovery and development
    • DOI 10.1016/S1359-6446(05)03681-0, PII S1359644605036810
    • Fura A. Role of pharmacologically active metabolites in drug discovery and development. Drug Discov. Today 11(3-4), 133-142 (2006). (Pubitemid 43375964)
    • (2006) Drug Discovery Today , vol.11 , Issue.3-4 , pp. 133-142
    • Fura, A.1
  • 93
    • 0036828336 scopus 로고    scopus 로고
    • Omapatrilat - The story of overture and octave
    • Andrew JSC. Omapatrilat - the story of overture and octave. Int. J. Cardiol. 86(1), 1-4 (2002).
    • (2002) Int. J. Cardiol. , vol.86 , Issue.1 , pp. 1-4
    • Jsc, A.1
  • 94
    • 0036855483 scopus 로고    scopus 로고
    • Investigation of bradykinin metabolism in human and rat plasma in the presence of the dual ACE/NEP inhibitors GW660511X and omapatrilat
    • DOI 10.1002/psc.419
    • Heudi O, Ramirez-Molina C, Marshall P, et al. Investigation of bradykinin metabolism in human and rat plasma in the presence of the dual ace/nep inhibitors gw 660511x and omapatrilat. J. Pept. Sci. 8(11), 591-600 (2002). (Pubitemid 35402309)
    • (2002) Journal of Peptide Science , vol.8 , Issue.11 , pp. 591-600
    • Heudi, O.1    Ramirez-Molina, C.2    Marshall, P.3    Amour, A.4    Peace, S.5    Mckeown, S.6    Abou-Shakra, F.7
  • 95
    • 0007668501 scopus 로고    scopus 로고
    • Effects of omapatrilat on blood pressure and the progression of renal failure in an experimental model of Type 2 diabetes mellitus
    • Garcia-Robles R, Villabla F, Gonzalez-Albarran O, et al. Effects of omapatrilat on blood pressure and the progression of renal failure in an experimental model of Type 2 diabetes mellitus. Am. J. Hypertens. 13(S2), 36A-36A (2000).
    • (2000) Am. J. Hypertens. , vol.13 , Issue.2
    • Garcia-Robles, R.1    Villabla, F.2    Gonzalez-Albarran, O.3
  • 96
    • 0037197093 scopus 로고    scopus 로고
    • Vasopeptidase inhibitors: A bradykinin link
    • Boix F. Vasopeptidase inhibitors: a bradykinin link. Lancet 359(9312), 1157-1158 (2002).
    • (2002) Lancet , vol.359 , Issue.9312 , pp. 1157-1158
    • Boix, F.1
  • 97
    • 67650488269 scopus 로고    scopus 로고
    • Synergistic drug combinations tend to improve therapeutically relevant selectivity
    • Lehar J, Krueger AS, Avery W, et al. Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat. Biotech. 27(7), 659-666 (2009).
    • (2009) Nat. Biotech. , vol.27 , Issue.7 , pp. 659-666
    • Lehar, J.1    Krueger, A.S.2    Avery, W.3
  • 98
    • 42149145171 scopus 로고    scopus 로고
    • Fixed dose drug combinations (FDCs): Rational or irrational: A view point
    • DOI 10.1111/j.1365-2125.2007.03089.x
    • Gautam CS, Saha L. Fixed dose drug combinations (FDCS): rational or irrational. A view point. Br. J. Clin. Pharmacol. 65(5), 795-796 (2008). (Pubitemid 351535085)
    • (2008) British Journal of Clinical Pharmacology , vol.65 , Issue.5 , pp. 795-796
    • Gautam, C.S.1    Saha, L.2
  • 99
    • 34347394696 scopus 로고    scopus 로고
    • Tapping the potential of fixed-dose combinations
    • DOI 10.1038/nrd2334, PII NRD2334
    • Herrick TM, Million RP. Tapping the potential of fixed-dose combinations. Nat. Rev. Drug Discov. 6(7), 513-514 (2007). (Pubitemid 47019440)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.7 , pp. 513-514
    • Herrick, T.M.1    Million, R.P.2
  • 100
    • 0024323082 scopus 로고
    • Hydroxypropylmethylcellulose sustained release technology
    • Hogan JE. Hydroxypropylmethylcellulose sustained release technology. Drug Dev. Ind. Pharm. 15(6), 975-999 (1989). (Pubitemid 19199639)
    • (1989) Drug Development and Industrial Pharmacy , vol.15 , Issue.6-7 , pp. 975-999
    • Hogan, J.E.1
  • 101
    • 61549086881 scopus 로고    scopus 로고
    • Adherence in patients transferred from immediate release metformin to a sustained release formulation: A population-based study
    • Donnelly LA, Morris AD, Pearson ER. Adherence in patients transferred from immediate release metformin to a sustained release formulation: a population-based study. Diabetes, Obes. Metab. 11(4), 338-342 (2009).
    • (2009) Diabetes, Obes. Metab. , vol.11 , Issue.4 , pp. 338-342
    • Donnelly, L.A.1    Morris, A.D.2    Pearson, E.R.3
  • 102
    • 0038941548 scopus 로고
    • Use of bioerodible polymers in self-regulated drug delivery systems
    • American Chemical Society, Washington, DC, USA
    • Heller J, Pangburn SH, Penhale DWH. Use of bioerodible polymers in self-regulated drug delivery systems. In: Controlled-Release Technology. American Chemical Society, Washington, DC, USA 172-187 (1987).
    • (1987) Controlled-Release Technology , pp. 172-187
    • Heller, J.1    Pangburn, S.H.2    Penhale, D.W.H.3
  • 105
    • 33747840618 scopus 로고    scopus 로고
    • Polymer conjugates as anticancer nanomedicines
    • DOI 10.1038/nrc1958, PII NRC1958
    • Duncan R. Polymer conjugates as anticancer nanomedicines. Nat. Rev. Cancer 6(9), 688-701 (2006). (Pubitemid 44286001)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.9 , pp. 688-701
    • Duncan, R.1
  • 107
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes: Scientific review
    • Inzucchi SE. Oral antihyperglycemic therapy for Type 2 diabetes: scientific review. JAMA 287(3), 360-372 (2002). (Pubitemid 34256388)
    • (2002) Journal of the American Medical Association , vol.287 , Issue.3 , pp. 360-372
    • Inzucchi, S.E.1
  • 108
    • 77954988618 scopus 로고    scopus 로고
    • Risk of acute myocardial infarction, stroke, heart failure, and death in elderly medicare patients treated with rosiglitazone or pioglitazone
    • Graham DJ, Ouellet-Hellstrom R, Macurdy TE, et al. Risk of acute myocardial infarction, stroke, heart failure, and death in elderly medicare patients treated with rosiglitazone or pioglitazone. JAMA 304(4), 411-418 (2010).
    • (2010) JAMA , vol.304 , Issue.4 , pp. 411-418
    • Graham, D.J.1    Ouellet-Hellstrom, R.2    MacUrdy, T.E.3
  • 109
    • 77955285732 scopus 로고    scopus 로고
    • Rosiglitazone revisited: An updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
    • Nissen SE, Wolski K. Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch. Intern. Med. 170(14), 1191-1201 (2010).
    • (2010) Arch. Intern. Med. , vol.170 , Issue.14 , pp. 1191-1201
    • Nissen, S.E.1    Wolski, K.2
  • 110
    • 77955504288 scopus 로고    scopus 로고
    • FDA puts rosiglitazone postmarketing trial on hold
    • Cohen D. FDA puts rosiglitazone postmarketing trial on hold. BMJ 341, c4017 (2010).
    • (2010) BMJ , vol.341
    • Cohen, D.1
  • 111
    • 12144273121 scopus 로고    scopus 로고
    • In vivo drug discovery in the zebrafish
    • DOI 10.1038/nrd1606
    • Zon LI, Peterson RT. In vivo drug discovery in the zebrafish. Nat. Rev. Drug Discov. 4(1), 35-44 (2005). (Pubitemid 40109588)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.1 , pp. 35-44
    • Zon, L.I.1    Peterson, R.T.2
  • 112
    • 45749158648 scopus 로고    scopus 로고
    • Identification of the cellular targets of bioactive small organic molecules using affinity reagents
    • Leslie BJ, Hergenrother PJ. Identification of the cellular targets of bioactive small organic molecules using affinity reagents. Chem. Soc. Rev. 37(7), 1347-1360 (2008).
    • (2008) Chem. Soc. Rev. , vol.37 , Issue.7 , pp. 1347-1360
    • Leslie, B.J.1    Hergenrother, P.J.2
  • 113
    • 21144440283 scopus 로고    scopus 로고
    • Chemical genetics to chemical genomics: Small molecules offer big insights
    • DOI 10.1039/b312875j
    • Spring DR. Chemical genetics to chemical genomics: small molecules offer big insights. Chem. Soc. Rev. 34(6), 472-482 (2005). (Pubitemid 40880427)
    • (2005) Chemical Society Reviews , vol.34 , Issue.6 , pp. 472-482
    • Spring, D.R.1
  • 114
    • 45749110640 scopus 로고    scopus 로고
    • Smallmolecule microarrays as tools in ligand discovery
    • Vegas AJ, Fuller JH, Koehler AN. Smallmolecule microarrays as tools in ligand discovery. Chem. Soc. Rev. 37(7), 1385-1394 (2008).
    • (2008) Chem. Soc. Rev. , vol.37 , Issue.7 , pp. 1385-1394
    • Vegas, A.J.1    Fuller, J.H.2    Koehler, A.N.3
  • 115
    • 35048856423 scopus 로고    scopus 로고
    • Simultaneous arming and structure/activity studies of natural products employing O-H insertions: An expedient and versatile strategy for natural products-based chemical genetics
    • DOI 10.1021/ja0733686
    • Peddibhotla S, Dang Y, Liu JO, Romo D. Simultaneous arming and structure/activity studies of natural products employing O-H insertions: an expedient and versatile strategy for natural products-based chemical genetics. J. Am. Chem. Soc. 129(40), 12222-12231 (2007). (Pubitemid 47556858)
    • (2007) Journal of the American Chemical Society , vol.129 , Issue.40 , pp. 12222-12231
    • Peddibhotla, S.1    Dang, Y.2    Liu, J.O.3    Romo, D.4
  • 116
    • 0344667656 scopus 로고    scopus 로고
    • Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein-Small-Molecule Interactions
    • DOI 10.1002/anie.200352164
    • Kanoh N, Kumashiro S, Simizu S, et al. Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions. Angew. Chem. Int. Ed. 42(45), 5584-5587 (2003). (Pubitemid 37509360)
    • (2003) Angewandte Chemie - International Edition , vol.42 , Issue.45 , pp. 5584-5587
    • Kanoh, N.1    Kumashiro, S.2    Simizu, S.3    Kondoh, Y.4    Hatakeyama, S.5    Tashiro, H.6    Osada, H.7
  • 118
    • 47649092399 scopus 로고    scopus 로고
    • Rapid identification of a putative interaction between b2-adrenoreceptor agonists and atf 4 using a chemical genomics approach
    • Ladwa SR, Dilly SJ, Clark AJ, Marsh A, Taylor PC. Rapid identification of a putative interaction between b2-adrenoreceptor agonists and atf 4 using a chemical genomics approach. ChemMedChem 3(5), 742-744 (2008).
    • (2008) ChemMedChem , vol.3 , Issue.5 , pp. 742-744
    • Ladwa, S.R.1    Dilly, S.J.2    Clark, A.J.3    Marsh, A.4    Taylor, P.C.5
  • 120
    • 47249146126 scopus 로고    scopus 로고
    • Drug target identification using side-effect similarity
    • DOI 10.1126/science.1158140
    • Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P. Drug target identification using side-effect similarity. Science 321(5886), 263-266 (2008). (Pubitemid 351989100)
    • (2008) Science , vol.321 , Issue.5886 , pp. 263-266
    • Campillos, M.1    Kuhn, M.2    Gavin, A.-C.3    Jensen, L.J.4    Bork, P.5
  • 121
    • 65649093070 scopus 로고    scopus 로고
    • Mapping adverse drug reactions in chemical space
    • Scheiber J, Jenkins JL, Sukuru SCK, et al. Mapping adverse drug reactions in chemical space. J. Med. Chem. 52(9), 3103-3107 (2009).
    • (2009) J. Med. Chem. , vol.52 , Issue.9 , pp. 3103-3107
    • Scheiber, J.1    Jenkins, J.L.2    Sck, S.3
  • 122
    • 33846646004 scopus 로고    scopus 로고
    • The prospects for "personalized medicine" in drug development and drug therapy
    • DOI 10.1038/sj.clpt.6100063, PII 6100063
    • Woodcock J. The prospects for 'personalized medicine' in drug development and drug therapy. Clin. Pharmacol. Ther. 81(2), 164-169 (2007). (Pubitemid 46174812)
    • (2007) Clinical Pharmacology and Therapeutics , vol.81 , Issue.2 , pp. 164-169
    • Woodcock, J.1
  • 123
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • DOI 10.1038/35057062
    • Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature 409(6822), 860-921 (2001). (Pubitemid 32165345)
    • (2001) Nature , vol.409 , Issue.6822 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3
  • 126
    • 33947219266 scopus 로고    scopus 로고
    • Large-scale mapping of human protein-protein interactions by mass spectrometry
    • Ewing RM, Chu P, Elisma F, et al. Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol. Syst. Biol. 3, 89 (2007).
    • (2007) Mol. Syst. Biol. , vol.3 , pp. 89
    • Ewing, R.M.1    Chu, P.2    Elisma, F.3
  • 127
    • 46349091971 scopus 로고    scopus 로고
    • The social network of a cell: Recent advances in interactome mapping
    • DOI 10.1016/S1387-2656(08)00001-X, PII S138726560800001X
    • Charbonnier S, Gallego O, Gavin AC. The social network of a cell: recent advances in interactome mapping. Biotechnol. Annu. Rev. 14, 1-28 (2008). (Pubitemid 351916583)
    • (2008) Biotechnology Annual Review , vol.14 , pp. 1-28
    • Charbonnier, S.1    Gallego, O.2    Gavin, A.-C.3
  • 132
    • 13844276627 scopus 로고    scopus 로고
    • Target-based drug discovery: Is something wrong?
    • DOI 10.1016/S1359-6446(04)03316-1, PII S1359644604033161
    • Sams-Dodd F. Target-based drug discovery: is something wrong? Drug Discov. Today 10(2), 139-147 (2005). (Pubitemid 40247812)
    • (2005) Drug Discovery Today , vol.10 , Issue.2 , pp. 139-147
    • Sams-Dodd, F.1
  • 133
    • 85157115359 scopus 로고    scopus 로고
    • Accessed 7 September
    • NASA: The Pioneer Missions. www.nasa.gov/centers/ames/missions/archive/ pioneer.html (Accessed 7 September 2010)
    • (2010) NASA: The Pioneer Missions


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.