Liver toxicity of sitaxentan in pulmonary arterial hypertension

European Respiratory Journal

Volumn 37, Issue 2, 2011, Pages 475-476

  Galie N ^a   Hoeper, M M ^b   Gibbs, J S R ^c   Simonneau, G ^d  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d HÔPITAL ANTOINE BÉCLÈRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMBRISENTAN; BILE SALT; BOSENTAN; PREDNISONE; SITAXSENTAN;

AMINOTRANSFERASE BLOOD LEVEL; DOSE RESPONSE; DRUG WITHDRAWAL; HUMAN; LETTER; LIVER FAILURE; LIVER INJURY; LIVER TOXICITY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; TOXIC HEPATITIS;

DRUG-INDUCED LIVER INJURY; HUMANS; HYPERTENSION, PULMONARY; ISOXAZOLES; LIVER FAILURE; PRACTICE GUIDELINES AS TOPIC; RECEPTORS, ENDOTHELIN; THIOPHENES;

EID: 79953665196     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00194810     Document Type: Letter

References (6)

1. Galiè N, Hoeper MM, Humbert M, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J 2009; 34: 1219-1263.
2. Barst RJ, Rich S, Widlitz A, et al. Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension: open-label pilot study. Chest 2002; 121: 1860-1868. (Pubitemid 34634407)
3. Hoeper MM, Olsson KM, Schneider A, et al. Severe hepatitis associated with sitaxentan and response to glucocorticoid therapy. Eur Respir J 2009; 33: 1518-1519.
4. Lee W-TN, Kirkham N, Johnson MK, et al. Sitaxentan-related acute liver failure in a patient with pulmonary arterial hypertension. Eur Respir J 2011; 37: 472-474.
5. Lavelle A, Sugrue R, Lawler G, et al. Sitaxentan-induced hepatic failure in two patients with pulmonary arterial hypertension. Eur Respir J 2009; 34: 770-771.
6. European Medicines Agency. Thelin (sitaxentan) to be withdrawn due to cases of unpredictable serious liver injury. www.ema.europa. eu/ema/index.jsp?curl5pages/news-and-events/news/2010/12/news-detail-001161. jsp&murl5menus/news-and-events/news-and-events.jsp& mid5WC0b01ac058004d5c1&jsenabled5true Date last updated: December 11, 2010. Date last accessed: December 16, 2010.