Prolonged methylene blue infusion in refractory septic shock: A case report

Canadian Journal of Anesthesia

Volumn 58, Issue 4, 2011, Pages 401-405

  Dumbarton, Tristan C ^a   Minor, Samuel ^a   Yeung, Colin K ^a   Green, Robert ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CEFTRIAXONE; CREATININE; FLUCONAZOLE; HYDROCORTISONE; LACTIC ACID; LEVOFLOXACIN; MEROPENEM; METHYLENE BLUE; METRONIDAZOLE; NITROGEN; NORADRENALIN; UREA; VANCOMYCIN; VASOPRESSIN;

AGED; ANURIA; ARTICLE; BACTERIAL INFECTION; BLOOD PRESSURE MONITORING; CASE REPORT; CHRONIC DRUG ADMINISTRATION; CLOSTRIDIUM DIFFICILE INFECTION; CONTINUOUS INFUSION; CONTINUOUS RENAL REPLACEMENT THERAPY; DOSE RESPONSE; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; ENDOTRACHEAL INTUBATION; FLUID RESUSCITATION; GLASGOW COMA SCALE; HUMAN; LACTATE BLOOD LEVEL; MALE; MYCOSIS; PERICARDIAL EFFUSION; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; STAPHYLOCOCCUS INFECTION; TACHYCARDIA; TRANSTHORACIC ECHOCARDIOGRAPHY; UNCONSCIOUSNESS;

AGED; HEMODYNAMICS; HUMANS; INFUSIONS, INTRAVENOUS; MALE; METHYLENE BLUE; SHOCK, SEPTIC;

EID: 79953660588     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12630-011-9458-x     Document Type: Article

References (25)

1. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345: 1368-77.
2. Nguyen HB, Rivers EP, Abrahamian FM, et al. Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med 2006; 48: 28-54.
3. Schneider F, Lutun P, Hasselmann M, Stoclet JC, Tempe JD. Methylene blue increases systemic vascular resistance in human septic shock. Preliminary observations. Intensive Care Med 1992; 18: 309-11.
4. Kwok ES, Howes D. Use of methylene blue in sepsis: a systematic review. J Intensive Care Med 2006; 21: 359-63. (Pubitemid 44664170)
5. Park BK, Shim TS, Lim CM, et al. The effects of methylene blue on hemodynamic parameters and cytokine levels in refractory septic shock. Korean J Intern Med 2005; 20: 123-8.
6. Evgenov OV, Bjertnaes LJ. Administration of methylene blue in human septic shock: renaissance of an old drug? Crit Care Med 2003; 31: 1601-2. author reply 1602.
7. Memis D, Karamanlioglu B, Yuksel M, Gemlik I, Pamukcu Z. The influence of methylene blue infusion on cytokine levels during severe sepsis. Anaesth Intensive Care 2002; 30: 755-62. (Pubitemid 35469712)
8. Donati A, Conti G, Loggi S, et al. Does methylene blue administration to septic shock patients affect vascular permeability and blood volume? Crit Care Med 2002; 30: 2271-7.
9. Kirov MY, Evgenov OV, Evgenov NV, et al. Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study. Crit Care Med 2001; 29: 1860-7. (Pubitemid 32980392)
10. Andresen M, Dougnac A, Diaz O, et al. Use of methylene blue in patients with refractory septic shock: impact on hemodynamics and gas exchange. J Crit Care 1998; 13: 164-8. (Pubitemid 29015271)
11. Koch HJ. Effects of methylene blue in septic shock. Crit Care Med 1996; 24: 1093-4. (Pubitemid 26189961)
12. Brown G, Frankl D, Phang T. Continuous infusion of methylene blue for septic shock. Postgrad Med J 1996; 72: 612-4. (Pubitemid 26345364)
13. Preiser JC, Lejeune P, Roman A, et al. Methylene blue administration in septic shock: a clinical trial. Crit Care Med 1995; 23: 259-64.
14. Rivers EP, Coba V, Whitmill M. Early goal-directed therapy in severe sepsis and septic shock: a contemporary review of the literature. Curr Opin Anaesthesiol 2008; 21: 128-40.
15. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008; 34: 17-60.
16. Marczin N, Tekeres M, Salzman AL, Szabo C. Methylene blue infusion in septic shock. Crit Care Med 1995; 23: 1936-8.
17. Schneider F. Methylene blue infusion in septic shock. Crit Care Med 1995; 23: 1935-6.
18. Weingartner R, Oliveira E, Oliveira ES, et al. Blockade of the action of nitric oxide in human septic shock increases systemic vascular resistance and has detrimental effects on pulmonary function after a short infusion of methylene blue. Braz J Med Biol Res 1999; 32: 1505-13. (Pubitemid 30053338)
19. Mayer B, Brunner F, Schmidt K. Inhibition of nitric oxide synthesis by methylene blue. Biochem Pharmacol 1993; 45: 367-74. (Pubitemid 23042635)
20. Paya D, Gray GA, Stoclet JC. Effects of methylene blue on blood pressure and reactivity to norepinephrine in endotoxemic rats. J Cardiovasc Pharmacol 1993; 21: 926-30. (Pubitemid 23160681)
21. Tsuneyoshi I, Kanmura Y, Yoshimura N. Nitric oxide as a mediator of reduced arterial responsiveness in septic patients. Crit Care Med 1996; 24: 1083-6. (Pubitemid 26189955)
22. Hata JS, Dellinger RP. Nitric oxide inhibition in the treatment of septic shock. Crit Care Med 1995; 23: 1621-4.
23. Gachot B, Bedos JP, Veber B, Wolff M, Regnier B. Short-term effects of methylene blue on hemodynamics and gas exchange in humans with septic shock. Intensive Care Med 1995; 21: 1027-31. (Pubitemid 26009318)
24. Juffermans NP, Vervloet MG, Daemen-Gubbels CR, Binnekade JM, de Jong M, Groeneveld AB. A dose-finding study of methylene blue to inhibit nitric oxide actions in the hemodynamics of human septic shock. Nitric Oxide 2010; 22: 275-80.
25. Mount JC, Rowe AS. Use of methylene blue for refractory septic shock during continuous venovenous hemodiafiltration. Pharmacotherapy 2010; 30: 323.