Antitumor, cytotoxic and antioxidant potential of aster thomsonii extracts

African Journal of Pharmacy and Pharmacology

Volumn 5, Issue 2, 2011, Pages 252-258

  Bibi, G ^a   Ihsan ul Haq, ^a   Ullah, N ^a   Mannan, A ^a,b   Mirza, B ^a  

^a QUAID I AZAM UNIVERSITY   (Pakistan)

^b Tobe Camp University Road Abbottabad   (Pakistan)

Author keywords

Antioxidant assay; Antitumor assay; Aster thomsonii; Brine shrimp toxicity assay; Dna protection assay; Sulforhodamine b assay

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; ASTER THOMSONII EXTRACT; HEXANE; METHANOL; PLANT EXTRACT; PLASMID DNA; SULFORHODAMINE B; UNCLASSIFIED DRUG; WATER;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; ASTER THOMSONII; ASTERACEAE; BIOASSAY; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA REPAIR; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; FRACTIONATION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; SHRIMP;

EID: 79953658576     PISSN: None     EISSN: 19960816     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Asker VSABE, Berg VDDJ, Tromp MNJL (1996). Structural aspects of antioxidant activity of flavonoids. Free Radic. Biol. Med., 20: 331-42.
2. Agnieszka N, Jan DY, Norbert B (2008). Flavonoid content and antioxidant activity of caraway roots (Carum carvi L.). Veg. Crop Res. Bull., 68: 127-133.
3. Ahmad MS, Hussain M, Hanif M, Ali S, Qayyum M, Mirza B (2008). Di and Tri organotin (IV) Esters of 3,4-Methylenedioxyphenylpropenoic Acid: Synthesis, Spectroscopic Characterization and Biological Screening for Antimicrobial, Cytotoxic and Antitumor Activities. Chem. Bio. Drug Design., 71: 568-576.
4. Almeida CE, Karnikowski MGO, Foleto R, Baldisserotto B (1995). Analysis of antidiarrhoeic effect of plants used in popular medicine. Rev. Saude. Public, 29: 428-33.
5. Attaguile G, Russo A, Campisi A, Savoca F, Acquaviva RN, Ragusa N, Vanella A (2000). Antioxidant activity and protective e¡ect on DNA cleavage of extracts from Cistus incanus L. and Cistus monspeliensis L. Cell Biol. Toxicol. 16: 83-90.
6. Chung CP, Park JB, Bae KH (1995). Pharmocological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast. Planta Med., 61: 150-153.
7. Cragg GM, Newman DJ, Snader KM (1997). Natural Products in Drug Discovery and Development. J. Nat. Prod., 60: 52-60.
8. Cronquist A (1955). Vascular plants of the Pacific Northwest: Compositae. Univ. Washington Press, Seattle, WA, pp. 5-343.
9. Fabricant DS, Farnsworth NR (2001). The Value of Plants Used in Traditional Medicine for Drug Discovery. Environ. Health Perspect., 109: 69-75.
10. Ferrigini NR, Putna JE, Anderson B, Jacobsen LB, Nichols DE, Moore DS, McLaughlin JL (1982). Modification and evaluation of the potato disc assay and antitumor screening of Euphorbia seeds. J. Nat. Prod., 45: 679-686.
11. Finney DJ (1971). Probit Analysis 3rd ed. Cambridge University Press, Cambridge.
12. Fricker SP, Buckley RG (1996). Comparison of two colorimetric assays as cytotoxicity endpoints for an in vitro screen for antitumour agents. Anticancer Res., 16: 3755-3760.
13. Galasky AB, Kozimor R, Piotrowski D, Powell R (1981). The crown gall potato disc bioassay as a preliminary screen for compounds with antitumor activity. J. Nat. Cancer, 6: 689-692.
14. Ghafoor A (2002). Asteraceae. In: Flora of Pakistan. (Eds.): Ali SI, Qaiser M. Missuri Botanical Press.
15. Houghton P, Fang R, Techatanawat I, Steventon G, Hylands PJ, Lee CC (2007). The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity. Methods, 42: 377-387.
16. Jacques EL, Pohlit AM, Nunomura SM, Da AC, Mustafa EV, Reis SK, Alecrim AM, Brito BR, De CS, Finney EK, Oliveira ED, Santos KD, Pereira LC, Castro LD, Rosha LF, Andrade MM, Henrique MC, Santos MD, Souza PD, Silva SG (2003). Screening of plants in Amazone state for lethality towards brine shrimp. Acta Amaz. 33: 93-104.
17. Keepers YP, Pizao PE, Peters GJ, Arke-Otte J, Winograd B, Pinedo HM (1991). Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing. Eur. J. Cancer, 27: 897-900.
18. Koehn FE, Carter GT (2005). The evolving role of natural products drug discovery. Nat. Rev., 4: 206-220.
19. Linton AH (1983). Antibiotics: Assessment of Antimicrobial Activity and Resistance. Russell AD, Quernel LB (Eds), Academic Press London, pp. 19-30.
20. Maria T, Silva AF, Brandao M, Mesquita TS, Fatima ED, Junior AS, Zani CL (2000). Biological screening of Brazilian medicinal plants. Mem. Inst. Oswaldo. Cruz., 95: 367-373.
21. Mayerhof ER, Koncz-Kalman RZ, Nawrath C, Bakkeren G, Crameri A, Angelis K, Redei GP, Schell JB, Hohn KJ (1991). T-DNA integration: a mode of illegitimate recombination in plants. Embo. J., 10: 697-704.
22. Meneghetti BH (1997). Avaliação da atividade antidiarréica e toxicidade ubaguda de Aster squamatus (Spreng.) Hieron. (Asteraceae) Universidade Federal de Santa Maria, Santa Maria, Master Dissertation in Pharmaceutical Science and Technology, p. 54.
23. Morita H, Nagashima S, Uchiumi Y, Kuroki O, Takeya K, Itokawa H (1996). Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus. Tokyo Chem. Pharmaceut. Bull., 44: 1026-1032.
24. Obeid HK, Allen MS, Bedgood DR, Prenzler PD, Robards K (2005). Investigation of Australian olive mill waste for recovery of biophenols. J. Agric. Food Chem., 53: 9911-9920.
25. Rehman A, Mannan A, Inayatullah S, Akhtar Z, Qayyum M, Mirza B (2009). Biological evaluation of Wild Thyme (Thymus serpyllum). Pharmaceut. Biol., 47(7): 628-633.
26. Rehman A, Choudhary MI, Thomsen WJ (2001). Bioassay Techniques for Drug Development. Amsterdam: Harwood Academic Publishers, pp. 9-25.
27. Shao Y, Ho C, Chin C (1997). Aster lingulatosides C and D cytotoxic triterpenoid saponins from Aster lingulatus. Phytochem., 44: 337-341.
28. Shirota O, Morita H, Takeya K, Itokawa H, Iitaka Y (1997) Cytotoxic triterpene from Aster tataricus. Nat. Med., 51: 170-172.
29. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR (1990). New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening. J. Natl. Cancer Inst., 82(13): 1107-1112.
30. Tian B, Hua Y (2005). Concentration dependence of prooxidant and antioxidant effects of aloin and aloe-emodin on DNA. Food Chem., 91: 413-418.
31. Wang C, Yu D (1998) Triterpenoid saponins from Aster auriculatus. Planta. Med. 64: 50-53.
32. Zielinska M, Haegele NF, Firschke C (2001). Fulminant thrombosis of mechanical mitral valve prosthesis. Heart, 86: 16.