Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2341-2344

  Dong, Yizhou ^a   Nakagawa Goto, Kyoko ^a   Lai, Chin Yu ^a   Morris Natschke, Susan L ^a   Bastow, Kenneth F ^a   Lee, Kuo Hsiung ^a,b  

^a University of North Carolina   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

4 Amino 2H pyran 2 one (APO) analogs; Cytotoxicity; Neo tanshinlactone

Indexed keywords

4 AMINO 2H PYRAN 2 ONE DERIVATIVE; ANTINEOPLASTIC AGENT; NEOTANSHINLACTONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; BENZOPYRANS; CELL LINE, TUMOR; DITERPENES; HUMANS; NEOPLASMS; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953324693     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.084     Document Type: Article

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11. 3OD): δ 7.80 m, 2H, Ar-H, 7.46 m, 3H, Ar-H, 6.46 (s, 1H, 5-H), 5.41 (s, 1H, 3-H), 2.52 (s, 1H, 1′-H), 0.85 (d, 2H, J = 6.4 Hz, 2′ & 3′-H)