The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei

Infection and Immunity

Volumn 79, Issue 4, 2011, Pages 1512-1525

  Burtnick, Mary N ^a   Brett, Paul J ^a   Harding, Sarah V ^b   Ngugi, Sarah A ^b   Ribot, Wilson J ^c   Chantratita, Narisara ^d   Scorpio, Angelo ^e   Milne, Timothy S ^b   Dean, Rachel E ^b   Fritz, David L ^c   Peacock, Sharon J ^f   Prior, Joanne L ^b   Atkins, Timothy P ^b   DeShazer, David ^c  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^d MAHIDOL OXFORD TROPICAL MEDICINE RESEARCH UNIT   (Thailand)

^e National Biodefense Analysis and Countermeasures Center   (United States)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN HCP; PROTEIN HCP1; PROTEIN HCP2; PROTEIN HCP3; PROTEIN HCP6; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; BAGG ALBINO MOUSE; BURKHOLDERIA PSEUDOMALLEI; CYTOTOXICITY; DELETION MUTANT; GIANT CELL; MELIOIDOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER; TYPE VI SECRETION SYSTEM;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; BURKHOLDERIA PSEUDOMALLEI; CRICETINAE; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENES, BACTERIAL; HUMANS; IMMUNOBLOTTING; LIVER; MACROPHAGES; MELIOIDOSIS; MESOCRICETUS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; VIRULENCE; VIRULENCE FACTORS;

EID: 79953319798     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01218-10     Document Type: Article

References (42)

1. Ashdown, L. R. 1979. Identification of Pseudomonas pseudomallei in the clinical laboratory. J. Clin. Pathol. 32:500-504.
2. Bernard, C. S., Y. R. Brunet, E. Gueguen, and E. Cascales. 2010. Nooks and crannies in type VI secretion regulation. J. Bacteriol. 192:3850-3860.
3. Boddey, J. A., et al. 2007. The bacterial gene lfpA influences the potent induction of calcitonin receptor and osteoclast-related genes in Burkholderia pseudomallei-induced TRAP-positive multinucleated giant cells. Cell. Microbiol. 9:514-531.
4. Bönemann, G., A. Pietrosiuk, and A. Mogk. 2010. Tubules and donuts: a type VI secretion story. Mol. Microbiol. 76:815-821.
5. Boyer, F., G. Fichant, J. Berthod, Y. Vandenbrouck, and I. Attree. 2009. Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources? BMC Genomics 10:104.
6. Brett, P. J., M. N. Burtnick, H. Su, V. Nair, and F. C. Gherardini. 2008. iNOS activity is critical for the clearance of Burkholderia mallei from infected RAW 264.7 murine macrophages. Cell. Microbiol. 10:487-498.
7. Burtnick, M. N., et al. 2008. Burkholderia pseudomallei type III secretion system mutants exhibit delayed vacuolar escape phenotypes in RAW 264.7 murine macrophages. Infect. Immun. 76:2991-3000.
8. Burtnick, M. N., D. DeShazer, V. Nair, F. C. Gherardini, and P. J. Brett. 2010. Burkholderia mallei cluster 1 type VI secretion mutants exhibit growth and actin polymerization defects in RAW 264.7 murine macrophages. Infect. Immun. 78:88-99.
9. DeShazer, D., P. J. Brett, R. Carlyon, and D. E. Woods. 1997. Mutagenesis of Burkholderia pseudomallei with Tn5-OT182: isolation of motility mutants and molecular characterization of the flagellin structural gene. J. Bacteriol. 179:2116-2125.
10. DeShazer, D., and D. E. Woods. 1999. Animal models of melioidosis, p. 199-203. In O. Zak and M. Sande (ed.), Handbook of animal models of infection. Academic Press Ltd., London, England.
11. Galyov, E. E., P. J. Brett, and D. DeShazer. 2010. Molecular insights into Burkholderia pseudomallei and Burkholderia mallei pathogenesis. Annu. Rev. Microbiol. 64:495-517.
12. Gilad, J., I. Harary, T. Dushnitsky, D. Schwartz, and Y. Amsalem. 2007. Burkholderia mallei and Burkholderia pseudomallei as bioterrorism agents: national aspects of emergency preparedness. Isr. Med. Assoc. J. 9:499-503.
13. Godoy, D., et al. 2003. Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei. J. Clin. Microbiol. 41:2068-2079.
14. Hamad, M. A., S. L. Zajdowicz, R. K. Holmes, and M. I. Voskuil. 2009. An allelic exchange system for compliant genetic manipulation of the select agents Burkholderia pseudomallei and Burkholderia mallei. Gene 430:123- 131.
15. Harley, V. S., D. A. B. Dance, B. S. Drasar, and G. Tovey. 1998. Effects of Burkholderia pseudomallei and other Burkholderia species on eukarotic cells in tissue culture. Microbios 96:71-93.
16. Helming, L., and S. Gordon. 2009. Molecular mediators of macrophage fusion. Trends Cell. Biol. 19:514-522.
17. Holden, M. T., et al. 2004. Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc. Natl. Acad. Sci. U. S. A. 101: 14240-14245.
18. Hood, R. D., et al. 2010. A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria. Cell Host Microbe 7:25-37.
19. Kespichayawattana, W., S. Rattanachetkul, T. Wanun, P. Utaisincharoen, and S. Sirisinha. 2000. Burkholderia pseudomallei induces cell fusion and actin-associated membrane protrusion: a possible mechanism for cell-to-cell spreading. Infect. Immun. 68:5377-5384.
20. Logue, C.-A., I. R. Peak, and I. R. Beacham. 2009. Facile construction of unmarked deletion mutants in Burkholderia pseudomallei using sacB counter-selection in sucrose-resistant and sucrose-sensitive isolates. J. Microbiol. Methods 76:320-323.
21. Ma, A. T., S. McAuley, S. Pukatzki, and J. J. Mekalanos. 2009. Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells. Cell Host Microbe 5:234-243.
22. National Research Council. 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington, DC.
23. Ngauy, V., Y. Lemeshev, L. Sadkowski, and G. Crawford. 2005. Cutaneous melioidosis in a man who was taken as a prisoner of war by the Japanese during World War II. J. Clin. Microbiol. 43:970-972.
24. Pilatz, S., et al. 2006. Identification of Burkholderia pseudomallei genes required for the intracellular life cycle and in vivo virulence. Infect. Immun. 74:3576-3586.
25. Pukatzki, S., A. T. Ma, A. T. Revel, D. Sturtevant, and J. J. Mekalanos. 2007. Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. Proc. Natl. Acad. Sci. U. S. A. 104: 15508-15513.
26. Pukatzki, S., S. B. McAuley, and S. T. Miyata. 2009. The type VI secretion system: translocation of effectors and effector-domains. Curr. Opin. Microbiol. 12:11-17.
27. Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty per cent endpoints. Am. J. Hyg. (Lond.) 27:493-497.
28. Schell, M. A., et al. 2007. Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol. Microbiol. 64:1466-1485.
29. Shalom, G., J. G. Shaw, and M. S. Thomas. 2007. In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages. Microbiology 153:2689- 2699.
30. Shanks, J., et al. 2009. Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophages. Infect. Immun. 77:1636-1648.
31. Simon, R., U. Priefer, and A. Puhler. 1983. A broad host range mobilization system for in vivo genetic engineering: tranposon mutagenesis in gram negative bacteria. Biotechnology (NY) 1:784-791.
32. Sprague, L. D., and H. Neubauer. 2004. Melioidosis in animals: a review on epizootiology, diagnosis and clinical presentation. J. Vet. Med. B Infect. Dis. Vet. Public Health 51:305-320.
33. Tan, K. S., et al. 2010. Suppression of host innate immune response by Burkholderia pseudomallei through the virulence factor TssM. J. Immunol. 184:5160-5171.
34. Ulrich, R. L., K. Amemiya, D. M. Waag, C. J. Roy, and D. DeShazer. 2005. Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice. Vaccine 23:1986-1992.
35. Utaisincharoen, P., S. Arjcharoen, K. Limposuwan, S. Tungpradabkul, and S. Sirisinha. 2006. Burkholderia pseudomallei RpoS regulates multinucleated giant cell formation and inducible nitric oxide synthase expression in mouse macrophage cell line (RAW 264.7). Microb. Pathog. 40:184-189.
36. Vietri, N. J., and D. DeShazer. 2007. Melioidosis, p. 147-166. In Z. F. Dembek (ed.), Medical aspects of biological warfare. Department of the Army, Office of The Surgeon General, Borden Institute, Washington, DC.
37. Voskuhl, G. W., P. Cornea, M. S. Bronze, and R. A. Greenfield. 2003. Other bacterial diseases as a potential consequence of bioterrorism: Q fever, brucellosis, glanders, and melioidosis. J. Okla. State Med. Assoc. 96:214-217.
38. Waag, D. M., and D. DeShazer. 2004. Glanders: new insights into an old disease, p. 209-237. In L. E. Lindler, F. J. Lebeda, and G. W. Korch (ed.), Biological weapons defense: infectious diseases and counterbioterrorism. Humana Press Inc., Totowa, NJ.
39. Whitlock, G. C., et al. 2010. Protective response to subunit vaccination against intranasal Burkholderia mallei and B. pseudomallei challenge. Proc. Vaccinol. 2:73-77.
40. Wilson, K. 1987. Preparation of genomic DNA from bacteria, p. 2.4.1-2.4.5. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons, New York, NY.
41. Wong, K. T., S. D. Puthucheary, and J. Vadivelu. 1995. The histopathology of human melioidosis. Histopathology 26:51-55.
42. Zheng, J., and K. Y. Leung. 2007. Dissection of a type VI secretion system in Edwardsiella tarda. Mol. Microbiol. 66:1192-1206.