Protein C inhibitor inhibits factor VIIa when bound to tissue factor

Journal of Thrombosis and Haemostasis

Volumn 9, Issue 4, 2011, Pages 861-863

  Fortenberry, Y M ^a   Hlavacek, A C ^b   Church, F C ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 7A; PLASMINOGEN ACTIVATOR INHIBITOR 3; SERINE PROTEINASE INHIBITOR; THROMBOPLASTIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL SURFACE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; KINETICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

CELL LINE, TUMOR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FACTOR VIIA; HUMANS; PROTEIN BINDING; PROTEIN C INHIBITOR; THROMBOPLASTIN;

EID: 79953313212     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2011.04196.x     Document Type: Article

References (9)

1. Lawson JH, Butenas S, Ribarik N, Mann KG. Complex-dependent inhibition of factor VIIa by antithrombin III and heparin. J Biol Chem 1993; 268: 767-70.
2. Jesty J, Lorenz A, Rodriguez J, Wun TC. Initiation of the tissue factor pathway of coagulation in the presence of heparin: control by antithrombin III and tissue factor pathway inhibitor. Blood 1996; 87: 2301-7.
3. Rao LV, Rapaport SI, Hoang AD. Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa. Blood 1993; 81: 2600-7.
4. Broze GJ Jr, Likert K, Higuchi D. Inhibition of factor VIIa/tissue factor by antithrombin III and tissue factor pathway inhibitor. Blood 1993; 82: 1679-81.
5. Kondo S, Kisiel W. Regulation of factor VIIa activity in plasma: evidence that antithrombin III is the sole plasma protease inhibitor of human factor VIIa. Thromb Res 1987; 46: 325-35.
6. Suzuki K. The multi-functional serpin, protein C inhibitor: beyond thrombosis and hemostasis. J Thromb Haemost 2008; 6: 2017-26.
7. Rau JC, Beaulieu LM, Huntington JA, Church FC. Serpins in thrombosis, hemostasis and fibrinolysis. J Thromb Haemost 2007; 5 (Suppl. 1): 102-15.
8. Cooper ST, Neese LL, DiCuccio MN, Liles DK, Hoffman M, Church FC. Vascular localization of the heparin-binding serpins antithrombin, heparin cofactor II, and protein C inhibitor. Clin Appl Thromb Hemost 1996; 2: 185-91.
9. Rehault SM, Zechmeister-Machhart M, Fortenberry YM, Malleier J, Binz NM, Cooper ST, Geiger M, Church FC. Characterization of recombinant human protein C inhibitor expressed in Escherichia coli. Biochim Biophys Acta 2005; 1748: 57-65.