Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity-letter

Cancer Research

Volumn 71, Issue 7, 2011, Pages 2793-

  Chou, Ting Chao ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITHRAMYCIN; TOLFENAMIC ACID; TRANSCRIPTION FACTOR SP1;

ANTINEOPLASTIC ACTIVITY; CELL KILLING; CELL SURVIVAL; DRUG POTENTIATION; HUMAN; LETTER; MATHEMATICAL ANALYSIS; PANCREAS CANCER; PRIORITY JOURNAL; PROBABILITY; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS;

ANIMALS; ANTHRANILIC ACIDS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DRUG SYNERGISM; HUMANS; PANCREATIC NEOPLASMS; PLICAMYCIN; SP1 TRANSCRIPTION FACTOR;

EID: 79953311303     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-0379     Document Type: Letter

References (7)

1. Jia Z, Gao Y, Wang L, Li Q, Zhang J, Le X, et al. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Res 2010;70:1111-9.
2. Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55.
3. Chou TC. Theoretical basis, experimental design, and computerized simulation of synergismand antagonism in drug combination studies. Pharmacol Rev 2006;68:621-81. Available from: http://pharmrev.aspetjournals.org/cgi/reprint/ 58/3/621.
4. Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 2010;70:440-6.
5. Chou TC. Preclinical versus clinical drug combination studies. Leuk Lymphoma 2008;49:2059-80.
6. Chou TC, Martin N. CompuSyn for drug combinations: PC software and user's guide: a computer program for quantitation of synergism and antagonism in drug combinations, and the determination of IC50 and ED50 and LD50 values. Paramus, NJ: ComboSyn; 2005.
7. Lee JJ, Kong M, Ayers GD, Lotan R. Interaction index and different methods for determining drug interaction in combination therapy. J Biopharm Stat 2007;17:461-80. (Pubitemid 46699662)