Impact of platinum-based chemotherapy on circulating nucleic acid levels, protease activities in blood and disseminated tumor cells in bone marrow of ovarian cancer patients

International Journal of Cancer

Volumn 128, Issue 11, 2011, Pages 2572-2580

  Wimberger, Pauline ^a   Roth, Carina ^b   Pantel, Klaus ^b   Kasimir Bauer, Sabine ^a   Kimmig, Rainer ^a   Schwarzenbach, Heidi ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

cell apoptosis; circulating caspase activities; circulating DNA; disseminated tumor cells

Indexed keywords

CARBOPLATIN; CASPASE; DNA; PACLITAXEL; PROTEINASE;

ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; BONE MARROW METASTASIS; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER SIZE; CANCER STAGING; CANCER SURGERY; CONTROLLED STUDY; DNA CONTENT; DNA DETERMINATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE ANALYSIS; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; NUCLEOSOME; OUTCOME ASSESSMENT; OVARY CANCER; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; RECURRENCE RISK;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; BONE MARROW NEOPLASMS; CARBOPLATIN; CASE-CONTROL STUDIES; CASPASES; DNA, NEOPLASM; FEMALE; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASTIC CELLS, CIRCULATING; OVARIAN NEOPLASMS; PEPTIDE HYDROLASES; PROGNOSIS; SURVIVAL RATE; YOUNG ADULT;

EID: 79953310989     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25602     Document Type: Article

References (25)

1. du Bois A, Quinn M, Thigpen T, Vermorken J, Avall-Lundqvist E, Bookman M, Bowtell D, Brady M, Casado A, Cervantes A, Eisenhauer E, Friedlaender M, et al. 2004 consensus statements on the management of ovarian cancer: final document of the 3rd International Gynecologic Cancer Intergroup Ovarian Cancer Consensus Conference (GCIG OCCC 2004). Ann Oncol 2005; 16 (Suppl 8): viii7-viii12. (Pubitemid 41631227)
2. du Bois A, Reuss A, Pujade-Lauraine E, Harter P, Ray-Coquard I, Pfisterer J,. Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO). Cancer 2009; 115: 1234-44.
3. Martin LP, Schilder RJ,. Management of recurrent ovarian carcinoma: current status and future directions. Semin Oncol 2009; 36: 112-25.
4. Banys M, Solomayer EF, Becker S, Krawczyk N, Gardanis K, Staebler A, Neubauer H, Wallwiener D, Fehm T,. Disseminated tumor cells in bone marrow may affect prognosis of patients with gynecologic malignancies. Int J Gynecol Cancer 2009; 19: 948-52.
5. Schindlbeck C, Hantschmann P, Zerzer M, Jahns B, Rjosk D, Janni W, Rack B, Sommer H, Friese K,. Prognostic impact of KI67, p53, human epithelial growth factor receptor 2, topoisomerase IIalpha, epidermal growth factor receptor, and nm23 expression of ovarian carcinomas and disseminated tumor cells in the bone marrow. Int J Gynecol Cancer 2007; 17: 1047-55. (Pubitemid 47414831)
6. Wimberger P, Heubner M, Otterbach F, Fehm T, Kimmig R, Kasimir-Bauer S,. Influence of platinum-based chemotherapy on disseminated tumor cells in blood and bone marrow of patients with ovarian cancer. Gynecol Oncol 2007; 107: 331-8. (Pubitemid 47575736)
7. Wimberger P, Heubner M, Lindhofer H, Jager M, Kimmig R, Kasimir-Bauer S,. Influence of catumaxomab on tumor cells in bone marrow and blood in ovarian cancer. Anticancer Res 2009; 29: 1787-91.
8. Holdenrieder S, Nagel D, Schalhorn A, Heinemann V, Wilkowski R, von Pawel J, Raith H, Feldmann K, Kremer AE, Muller S, Geiger S, Hamann GF, et al. Clinical relevance of circulating nucleosomes in cancer. Ann N Y Acad Sci 2008; 1137: 180-9.
9. Fleischhacker M, Schmidt B,. Circulating nucleic acids (CNAs) and cancer-a survey. Biochim Biophys Acta 2007; 1775: 181-232. (Pubitemid 44911084)
10. Kamat AA, Sood AK, Dang D, Gershenson DM, Simpson JL, Bischoff FZ,. Quantification of total plasma cell-free DNA in ovarian cancer using real-time PCR. Ann N Y Acad Sci 2006; 1075: 230-4. (Pubitemid 44532789)
11. Stroun M, Lyautey J, Lederrey C, Olson-Sand A, Anker P,. About the possible origin and mechanism of circulating DNA apoptosis and active DNA release. Clin Chim Acta 2001; 313: 139-42. (Pubitemid 33016703)
12. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S,. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998; 391: 43-50. (Pubitemid 28079208)
13. Choi JJ, Reich CF, III, Pisetsky DS,. The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells. Immunology 2005; 115: 55-62. (Pubitemid 40593291)
14. Rumore P, Muralidhar B, Lin M, Lai C, Steinman CR,. Haemodialysis as a model for studying endogenous plasma DNA: oligonucleosome-like structure and clearance. Clin Exp Immunol 1992; 90: 56-62.
15. Lopez-Otin C, Matrisian LM,. Emerging roles of proteases in tumour suppression. Nat Rev Cancer 2007; 7: 800-8. (Pubitemid 47463671)
16. Turk B,. Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov 2006; 5: 785-99. (Pubitemid 44323703)
17. Wimberger P, Wehling M, Lehmann N, Kimmig R, Schmalfeldt B, Burges A, Harter P, Pfisterer J, du Bois A,. Influence of residual tumor on outcome in ovarian cancer patients with FIGO stage IV disease: an exploratory analysis of the AGO-OVAR (Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group). Ann Surg Oncol 2010; 17: 1642-8.
18. Pantel K, Brakenhoff RH,. Dissecting the metastatic cascade. Nat Rev Cancer 2004; 4: 448-56. (Pubitemid 38745530)
19. Pantel K, Brakenhoff RH, Brandt B,. Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer 2008; 8: 329-40. (Pubitemid 351596394)
20. Aimes RT, Zijlstra A, Hooper JD, Ogbourne SM, Sit ML, Fuchs S, Gotley DC, Quigley JP, Antalis TM,. Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Thromb Haemost 2003; 89: 561-72. (Pubitemid 36329249)
21. Graves LE, Ariztia EV, Navari JR, Matzel HJ, Stack MS, Fishman DA,. Proinvasive properties of ovarian cancer ascites-derived membrane vesicles. Cancer Res 2004; 64: 7045-9. (Pubitemid 39331015)
22. Fehm T, Becker S, Bachmann C, Beck V, Gebauer G, Banys M, Wallwiener D, Solomayer EF,. Detection of disseminated tumor cells in patients with gynecological cancers. Gynecol Oncol 2006; 103: 942-7. (Pubitemid 44821319)
23. Braun S, Schindlbeck C, Hepp F, Janni W, Kentenich C, Riethmuller G, Pantel K,. Occult tumor cells in bone marrow of patients with locoregionally restricted ovarian cancer predict early distant metastatic relapse. J Clin Oncol 2001; 19: 368-75. (Pubitemid 32112848)
24. Abdul-Karim FW, Kida M, Wentz WB, Carter JR, Sorensen K, Macfee M, Zika J, Makley JT,. Bone metastasis from gynecologic carcinomas: a clinicopathologic study. Gynecol Oncol 1990; 39: 108-14. (Pubitemid 20372394)
25. Dauplat J, Hacker NF, Nieberg RK, Berek JS, Rose TP, Sagae S,. Distant metastases in epithelial ovarian carcinoma. Cancer 1987; 60: 1561-6. (Pubitemid 17141009)