P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice.

Drug metabolism letters

Volumn 4, Issue 4, 2010, Pages 195-201

  Tagen, Michael ^a   Zhuang, Yanli ^b   Zhang, Fan ^b   Harstead, K Elaine ^b   Shen, Jun ^b   Schaiquevich, Paula ^b   Fraga, Charles H ^b   Panetta, John C ^b   Waters, Christopher M ^b   Stewart, Clinton F ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ABCC4 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CARBOXYLIC ACID; DRUG DERIVATIVE; GLYCOPROTEIN P; IRINOTECAN; LACTONE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 3; P GLYCOPROTEIN 2; P-GLYCOPROTEIN 2;

129 MOUSE; ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOTRANSFORMATION; BLOOD; C57BL MOUSE; FEMALE; GENETICS; GENOTYPE; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MOUSE; MOUSE MUTANT; PHENOTYPE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOTRANSFORMATION; CAMPTOTHECIN; CARBOXYLIC ACIDS; FEMALE; GENOTYPE; INJECTIONS, INTRAVENOUS; LACTONES; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEINS; PHENOTYPE;

EID: 79953306305     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231210792928251     Document Type: Article

References (0)