The "generic" effect of food on tacrolimus pharmacokinetics

Clinical Transplantation

Volumn 25, Issue 2, 2011, Pages 334-335

  Steiner, R W ^a   Feist, A A ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; GENERIC DRUG; TACROLIMUS;

AREA UNDER THE CURVE; BIOEQUIVALENCE; DRUG ABSORPTION; DRUG APPROVAL; FOOD AND DRUG ADMINISTRATION; FOOD DRUG INTERACTION; GRAFT RECIPIENT; HUMAN; LETTER; MAXIMUM PLASMA CONCENTRATION; PRIORITY JOURNAL;

AREA UNDER CURVE; CROSS-OVER STUDIES; DRUGS, GENERIC; FASTING; FOOD; HUMANS; IMMUNOSUPPRESSIVE AGENTS; TACROLIMUS; TISSUE DISTRIBUTION;

EID: 79953304474     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2010.01387.x     Document Type: Letter

References (5)

1. Pondrom S. AJT report: can generics be trusted? Am J Transplant 2010: 10: 708.
2. ® capsules). Sandoz Tacrolimus Capsules ANDA #65-461. August 2009. Available at: (accessed 2 September 2010).
3. Kimikawa M, Kamoya K, Toma H, Teraoka S. Effective oral administration of tacrolimus in renal transplant recipients. Clin Transplant 2001: 15: 324.
4. Curtis JJ, Jones P, Barbeito R. Large within-day variation in cyclosporine absorption: circadian variation or food effect? Clin J Am Soc Nephrol 2006: 17: 462.
5. Batarse R, Awdishu L, Dominguez A, Lane J, Steiner R. There is no free lunch: the negative consequences of taking cyclosporine with food [abstract]. National Kidney Foundation Spring Clinical Meeting, April 10-14 2007; Orlando, FL.