Factor XIII supports platelet activation and enhances thrombus formation by matrix proteins under flow conditions

Journal of Thrombosis and Haemostasis

Volumn 9, Issue 4, 2011, Pages 820-833

  Magwenzi, S G ^a   Ajjan, R A ^b   Standeven, K F ^b   Parapia, L A ^c   Naseem, K M ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Factor XIII; Integrin signaling; Platelets; Thrombosis

Indexed keywords

BLOOD CLOTTING FACTOR 13A; CALCIUM; COLLAGEN; FIBRINOGEN; INTEGRIN; INTEGRIN ALPHA2BBETA3; PROTEIN DISULFIDE ISOMERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN KINASE SYK; PYRIMIDINE DERIVATIVE; TIROFIBAN; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; VON WILLEBRAND FACTOR; BLOOD CLOTTING FACTOR 13; FIBRINOGEN RECEPTOR; SCLEROPROTEIN;

ARTERY BLOOD FLOW; ARTICLE; BLOOD VESSEL INJURY; CALCIUM MOBILIZATION; CELL SPREADING; CLINICAL EVALUATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FILOPODIUM; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LAMELLIPODIUM; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOGENESIS; VEIN BLOOD FLOW; CELL ADHESION; CYTOLOGY; IMMUNOPRECIPITATION; PATHOPHYSIOLOGY; PHYSIOLOGY; THROMBOCYTE; THROMBOSIS;

BLOOD PLATELETS; CELL ADHESION; EXTRACELLULAR MATRIX PROTEINS; FACTOR XIII; HUMANS; IMMUNOPRECIPITATION; INTEGRIN ALPHAVBETA3; MICROSCOPY, FLUORESCENCE; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; THROMBOSIS;

EID: 79953301142     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2011.04234.x     Document Type: Article

References (36)

1. Ruggeri ZM, Mendolicchio GL. Adhesion mechanisms in platelet function. Circ Res 2007; 100: 1673-85.
2. White TC, Berny MA, Tucker EI, Urbanus RT, De Groot PG, Fernandez JA, Griffin JH, Gruber A, McCarty OJ. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2. J Thromb Haemost 2008; 6: 995-1002.
3. White-Adams TC, Berny MA, Tucker EI, Gertz JM, Gailani D, Urbanus RT, De Groot PG, Gruber A, McCarty OJ. Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arterioscler Thromb Vasc Biol 2009; 29: 1602-7.
4. Muszbek L, Yee VC, Hevessy Z. Blood coagulation factor XIII: structure and function. Thromb Res 1999; 94: 271-305.
5. Lorand L. Factor XIII: structure, activation, and interactions with fibrinogen and fibrin. Ann N Y Acad Sci 2001; 936: 291-311.
6. Marx G, Korner G, Mou X, Gorodetsky R. Packaging zinc, fibrinogen, and factor XIII in platelet alpha-granules. J Cell Physiol 1993; 156: 437-42.
7. Cox AD, Devine DV. Factor XIIIa binding to activated platelets is mediated through activation of glycoprotein IIb-IIIa. Blood 1994; 83: 1006-16.
8. Greenberg CS, Shuman MA. Specific binding of blood coagulation factor XIIIa to thrombin-stimulated platelets. J Biol Chem 1984; 259: 14721-7.
9. Dale GL, Friese P, Batar P, Hamilton SF, Reed GL, Jackson KW, Clemetson KJ, Alberio L. Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface. Nature 2002; 415: 175-9.
10. Dardik R, Shenkman B, Tamarin I, Eskaraev R, Harsfalvi J, Varon D, Inbal A. Factor XIII mediates adhesion of platelets to endothelial cells through alpha(v)beta(3) and glycoprotein IIb/IIIa integrins. Thromb Res 2002; 105: 317-23.
11. Song YC, Sheng D, Taubenfeld SM, Matsueda GR. A microtiter assay for factor XIII using fibrinogen and biotinylcadaverine as substrates. Anal Biochem 1994; 223: 88-92.
12. Lahav J, Karniel E, Bagoly Z, Sheptovitsky V, Dardik R, Inbal A. Coagulation factor XIII serves as protein disulfide isomerase. Thromb Haemost 2009; 101: 840-4.
13. Riba R, Hughes CE, Graham A, Watson SP, Naseem KM. Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex. J Thromb Haemost 2008; 6: 1012-20.
14. Maxwell MJ, Westein E, Nesbitt WS, Giuliano S, Dopheide SM, Jackson SP. Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation. Blood 2007; 109: 566-76.
15. Ross JM, McIntire LV, Moake JL, Rand JH. Platelet adhesion and aggregation on human type VI collagen surfaces under physiological flow conditions. Blood 1995; 85: 1826-35.
16. Savage B, Almus-Jacobs F, Ruggeri ZM. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell 1998; 94: 657-66.
17. Matsui H, Sugimoto M, Mizuno T, Tsuji S, Miyata S, Matsuda M, Yoshioka A. Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow. Blood 2002; 100: 3604-10.
18. Siebenlist KR, Meh DA, Mosesson MW. Plasma factor XIII binds specifically to fibrinogen molecules containing gamma chains. Biochemistry 1996; 35: 10448-53.
19. Dardik R, Krapp T, Rosenthal E, Loscalzo J, Inbal A. Effect of FXIII on monocyte and fibroblast function. Cell Physiol Biochem 2007; 19: 113-20.
20. Gawaz M, Neumann FJ, Dickfeld T, Reininger A, Adelsberger H, Gebhardt A, Schomig A. Vitronectin receptor (alpha(v)beta3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction. Circulation 1997; 96: 1809-18.
21. Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol 2002; 157: 265-75.
22. Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin alphaIIb beta3 signaling in platelets. J Thromb Haemost 2005; 3: 1752-62.
23. Goncalves I, Hughan SC, Schoenwaelder SM, Yap CL, Yuan Y, Jackson SP. Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2. J Biol Chem 2003; 278: 34812-22.
24. Daniel JL, Dangelmaier C, Smith JB. Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization. Biochem J 1994; 2: 617-22.
25. Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002; 8: 1227-34.
26. Kikuchi T, Takagi J, Kasahara K, Inada Y, Saito Y. Interaction between plasma factor XIII and collagen. Thromb Res 1986; 43: 213-18.
27. Nagy B Jr, Simon Z, Bagoly Z, Muszbek L, Kappelmayer J. Binding of plasma factor XIII to thrombin-receptor activated human platelets. Thromb Haemost 2009; 102: 83-9.
28. Nurden AT, Poujol C, Durrieu-Jais C, Nurden P. Platelet glycoprotein IIb/IIIa inhibitors: basic and clinical aspects. Arterioscler Thromb Vasc Biol 1999; 19: 2835-40.
29. Smith JW, Ruggeri ZM, Kunicki TJ, Cheresh DA. Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem 1990; 265: 12267-71.
30. Lauer P, Metzner HJ, Zettlmeissl G, Li M, Smith AG, Lathe R, Dickneite G. Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit. Thromb Haemost 2002; 88: 967-74.
31. Kasahara K, Souri M, Kaneda M, Miki T, Yamamoto N, Ichinose A. Impaired clot retraction in factor XIII A subunit-deficient mice. Blood 2009; 115: 1277-9.
32. Ozsoylu S, Hicsonmez G. Platelet aggregation in congenital factor XIII deficiency. Acta Haematol 1976; 56: 314-17.
33. Anwar R, Minford A, Gallivan L, Trinh CH, Markham AF. Delayed umbilical bleeding - a presenting feature for factor XIII deficiency: clinical features, genetics, and management. Pediatrics 2002; 109 [E32]: 1-7.
34. Bereczky Z, Balogh E, Katona E, Czuriga I, Edes I, Muszbek L. Elevated factor XIII level and the risk of myocardial infarction in women. Haematologica 2007; 92: 287-8.
35. Shemirani AH, Szomjak E, Csiki Z, Katona E, Bereczky Z, Muszbek L. Elevated factor XIII level and the risk of peripheral artery disease. Haematologica 2008; 93: 1430-2.
36. Devine DV, Andestad G, Nugent D, Carter CJ. Platelet-associated factor XIII as a marker of platelet activation in patients with peripheral vascular disease. Arterioscler Thromb 1993; 13: 857-62.